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Sperm Antibody Total

Sperm Antibody Total

Also referred as
Sperm Antibody (ASAB) -Total
For men & women
Earliest reports in
168-192 hours
Contains
1 test
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The Anti Sperm Antibody test is a blood test detecting immune proteins that may interfere with sperm function. This test helps evaluate unexplained infertility in couples, particularly when other causes are ruled out.

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Blood
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Understanding Sperm Antibody Total

Anti-sperm antibodies (ASA) are abnormal immune proteins that attack sperm cells as if they were harmful invaders. Normally, the immune system defends the body against infections, but in some cases, it wrongly identifies sperm as foreign and produces antibodies against them.

In men, these antibodies may develop after testicular injury, surgery (such as vasectomy reversal), or reproductive tract infections. They can attach to the sperm head, tail, or midpiece, making it harder for sperm to swim, pass through cervical mucus, or fertilize the egg. In women, the immune system may form antibodies in the blood or cervical mucus, impairing sperm function and preventing conception.

The Anti Sperm Antibody test is important in evaluating unexplained infertility, repeated pregnancy failures, or reduced sperm motility despite normal sperm count. It may also be recommended in men after testicular trauma, surgery, or chronic reproductive tract infections, and in women when immune-related infertility is suspected. By detecting anti-sperm antibodies, the test contributes to the overall fertility work-up as part of a comprehensive evaluation and not as a standalone test for treatment decisions. 

No special preparation is required for the Sperm Antibody Total test. Inform the doctor about all the medications and supplements currently being taken, as these may affect the test results.

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Do not self-medicate and always consult a doctor to understand the test results correctly. 

Please note: This is an outsourced test. The sample is collected by TATA 1MG and processed at a NABL accredited partnered lab.

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What does Sperm Antibody Total measure?

The Sperm Antibody Total test measures the presence of antibodies directed against sperm cells. These antibodies may attach to the sperm head, midpiece, or tail, reducing their motility, preventing them from entering cervical mucus, or blocking fertilization with the egg. However, the test does not quantify functional impact or site-specific binding on sperm.

  • In men: Anti-sperm antibodies may develop after testicular injury, surgery, or infections, leading to reduced sperm function.
  • In women: Antibodies in cervical mucus or blood can attack incoming sperm, preventing successful conception.

A positive result indicates the presence of anti-sperm antibodies, which may contribute to infertility. A negative result means antibodies were not detected, but further fertility evaluation may still be necessary.

FAQs related to Sperm Antibody Total

Yes. Men may develop anti-sperm antibodies due to testicular injury, surgery, vasectomy reversal, or infections. Women may develop them in blood or cervical mucus as an immune reaction to sperm.
There are usually no direct symptoms. This test is recommended if a couple has unexplained infertility, repeated failed pregnancies, or abnormal semen test results showing reduced sperm motility.
No. Fasting is not required. You can eat and drink normally before giving a semen or blood sample.
Not necessarily. A positive result means antibodies are present, but many couples can still conceive with treatment options such as intrauterine insemination (IUI), in vitro fertilization (IVF), or intracytoplasmic sperm injection (ICSI).
No specific lifestyle changes can remove antibodies once formed, but maintaining good reproductive health, treating infections early, and avoiding testicular injuries can reduce the risk.
Not usually. Sperm count may remain normal, but antibodies can reduce sperm motility and ability to fertilize the egg.
After a vasectomy reversal, the immune system may start producing antibodies against sperm, which can interfere with fertility. The test helps to check this.
Yes. In some women, the immune system reacts to sperm proteins after exposure, leading to antibody production in cervical mucus or blood, which can cause fertility problems.
Not always. Some couples may still conceive naturally, while others may need assisted reproductive techniques.
Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.
Content created by
Written by:
Shweta Prakash
MSc, BSc
Reviewed by:
Dr. Swati Gupta (Anand)
MBBS, MD Lab Medicine
Want to know moreRead our editorial policy
Last Updated25th Jan 2026

Sperm Antibody Total test price for other cities

Price inBangaloreRs. 1219
Price inNew DelhiRs. 1129
Price inHyderabadRs. 1049
Price inChennaiRs. 1049
Price inKolkataRs. 989

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References

  1. 1
    Gupta S, Sharma R, Agarwal A, Boitrelle F, Finelli R, Farkouh A, Saleh R, Abdel-Meguid TA, Gül M, Zilaitiene B, Ko E, Rambhatla A, Zini A, Leisegang K, Kuroda S, Henkel R, Cannarella R, Palani A, Cho CL, Ho CCK, Zylbersztejn DS, Pescatori E, Chung E, Dimitriadis F, Pinggera GM, Busetto GM, Balercia G, Salvio G, Colpi GM, Çeker G, Taniguchi H, Kandil H, Park HJ, Maldonado Rosas I, de la Rosette J, Cardoso JPG, Ramsay J, Alvarez J, Molina JMC, Khalafalla K, Bowa K, Tremellen K, Evgeni E, Rocco L, Rodriguez Peña MG, Sabbaghian M, Martinez M, Arafa M, Al-Marhoon MS, Tadros N, Garrido N, Rajmil O, Sengupta P, Vogiatzi P, Kavoussi P, Birowo P, Kosgi R, Bani-Hani S, Micic S, Parekattil S, Jindal S, Le TV, Mostafa T, Toprak T, Morimoto Y, Malhotra V, Aghamajidi A, Durairajanayagam D, Shah R. Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices. World J Mens Health. 2022 Jul;40(3):380-398. [Accessed 08 Sep. 2025]. Available From:
    https://pmc.ncbi.nlm.nih.gov/articles/PMC9253805/
  2. 2

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Contains 1 test
Sperm Antibody Total