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PSA (Prostate Specific Antigen) Total

PSA (Prostate Specific Antigen) Total

Also referred as
PSA blood test
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The PSA (Prostate Specific Antigen) Total test is a blood test that measures the total amount of PSA, a protein produced by the prostate gland that helps liquefies the semen in males. This test helps identify conditions like prostate inflammation (prostatitis), enlarged prostate (benign prostatic hyperplasia or BPH), prostate cancer, etc.

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Understanding PSA (Prostate Specific Antigen) Total

The prostate is a small, walnut-shaped gland located just below the bladder in men. It produces a protein called PSA, which helps liquify semen and allows sperms to move freely during ejaculation. The PSA (Prostate Specific Antigen) Total test measures the total amount of PSA in the blood, which indicates the combined level of all PSA, both free and bound to other proteins..

Your doctor may suggest the PSA (Prostate Specific Antigen) Total test if you have:

  • Trouble urinating 
  • Frequent urination (especially at night)
  • Blood in urine
  • Pain or burning while urinating

The PSA test is not recommended for routine prostate cancer screening in the general population. Testing is advised for men over 50 with average risk, and for those over 40 if they are at higher risk such as having a family history of prostate issues.

No fasting is required for this test. Eat and drink as per your daily routine. Avoid sexual intercourse for 48 hours before the test. Inform your doctor about all the medications that you are taking at the moment. Do not take the test right after a prostate exam, biopsy, or catheter use, as these factors may cause a false increase in PSA levels. 

High PSA levels may indicate an enlarged prostate, inflammation of the prostate, infection, or cancer. Low PSA levels (after treatment) may not always confirm that the disease is gone. Additionally, a PSA test alone does not always confirm cancer. Your doctor may suggest further investigations (such as a biopsy, digital rectal examination (DRE), etc.).

Total PSA test results may vary across different laboratories due to different testing methods. Hence, prefer using the same lab every time for repeat PSA testing. This helps ensure consistent results. Remember, early prostate cancer may not always show up in a PSA test. That is why your doctor may recommend additional testing if you have risk factors or symptoms.

What are the Symptoms or Conditions That May Require the PSA (Prostate Specific Antigen) Total Test?

You may need the PSA total test if you experience symptoms such as:

  • Difficulty starting or maintaining urine flow
  • Frequent urination, especially at night
  • Weak urine stream or dribbling
  • Pain or burning during urination
  • Blood in urine or semen
  • Pelvic or lower back pain

Your doctor may also recommend this test to:

  • Screen for prostate disorders in men above 50 years (or earlier in high-risk groups)
  • Detect prostate carcinoma (prostate cancer)
  • Monitor prostate cancer progression or treatment response
  • Detect recurrence of prostate cancer after therapy

When Would I Need the PSA (Prostate Specific Antigen) Total Test?

You may need the PSA (Prostate Specific Antigen) Total test if: 

  • As a screening test to detect prostate cancer early and to determine its stage and progression.
  • You have urinary difficulties, pelvic pain, or blood in urine or semen.
  • Your doctor suspects prostate enlargement, inflammation, or infection.
  • You are undergoing treatment for prostate cancer and need regular monitoring.
  • You have a family history of prostate cancer or are at increased risk.
  • You are over 50 years of age and undergoing a routine health check.

How Do I Prepare for the PSA (Prostate Specific Antigen) Total Test?

Do I need to fast or stop any medications before the PSA (Prostate Specific Antigen) Total test?

Fasting is not required before the PSA (Prostate Specific Antigen) Total test. Inform your doctor about any medications or supplements you are taking, as they may affect your results. However, to ensure accurate results, avoid sexual intercourse, ejaculation, and strenuous exercise for at least 48 hours before sample collection, as these can temporarily raise PSA levels. Do not take the test within 7 days of a digital rectal examination (DRE) or rectal prostatic ultrasonography. If you have recently had a prostate biopsy, consult your doctor about when to schedule the test, as it can significantly elevate PSA levels. 

How is the PSA (Prostate Specific Antigen) Total done?

  • The PSA (Prostate Specific Antigen) Total is done by collecting a small amount of blood from a vein, usually in the arm. 
  • The procedure is quick, minimally invasive, and generally causes only slight discomfort.

What happens during the PSA (Prostate Specific Antigen) Total test?

  • You will be seated comfortably with your arm supported on a flat surface or armrest.
  • A tourniquet (elastic band) is tied around your upper arm to make the veins more visible and easier to locate.
  • The phlebotomist identifies a suitable vein for blood collection.
  • The puncture site is then cleaned thoroughly with an alcohol swab to reduce the risk of infection.
  • A thin, sterile needle is gently inserted into the vein, and a small amount of blood is collected into a test tube.

What happens after the PSA (Prostate Specific Antigen) Total test?

  • Once enough blood is collected, the tourniquet is released and the needle is removed.
  • A cotton ball or gauze is placed on the site, followed by a small bandage or dressing to stop any bleeding.
  • The blood sample is carefully labeled with your details and sent to the laboratory for analysis.
  • You can resume your daily routine after the test is done.

Is the PSA (Prostate Specific Antigen) Total test painful?

No, the PSA (Prostate Specific Antigen) Total test is generally safe and painless. However, you may feel slight discomfort during blood sample collection, but the chances of serious complications are extremely rare.

How Long Does the PSA (Prostate Specific Antigen) Total Test Take?

The Total PSA test procedure is quick, simple, and safe. It requires only a small blood sample and is completed within a short duration.

When Will I Get the Results?

The availability of PSA total test report may vary depending on your location and the laboratory where the test is conducted. In general, Tata 1mg provides the results within the stipulated time after sample collection.

When Should I Consult a Doctor After the Test?

You should consult your doctor if your PSA level is above normal, especially if you have urinary symptoms or pelvic discomfort. Your doctor will interpret PSA results along with your medical history and may suggest additional imaging or biopsy.

Are There Any Risks Associated with the PSA (Prostate Specific Antigen) Total Test?

The PSA (Prostate Specific Antigen) Total test is safe, with only minimal and short-lasting effects like:

  • Small bruise, pinch, or slight tenderness at the puncture site
  • Occasional lightheadedness if you are sensitive to needles or blood
  • Rarely, infection or blood vessel injury

Note: If you have a bleeding disorder or take blood thinners, inform the phlebotomist beforehand.

Lifestyle Tips to Keep PSA (Prostate Specific Antigen) Levels in Healthy Range: 

🥙 Healthy Diet: Eat food like tomatoes, broccoli, legumes, whole grains, etc., to support your PSA levels. Avoid a high-fat diet.

🩺 Early Screening: PSA testing is recommended to begin in the early 50s, or earlier for those at higher risk of prostate cancer.

🚴 Activity (Exercise): Engage in regular moderate exercise. Regular exercise helps maintain a healthy weight and supports prostate function.

💆 Lifestyle (Stress): Manage stress with yoga, meditation, or deep breathing to support healthy PSA levels. 

👨‍⚕️Talk to Your Doctor (Consult): Consult your doctor to know when to get a PSA test, especially if you are at higher risk.

🚭Habits (Alcohol & Smoking): These habits can negatively affect your prostate health.

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What does PSA (Prostate Specific Antigen) Total measure?

The PSA (Prostate Specific Antigen) Total test measures the level of prostate-specific antigen (PSA) in the blood. It is a protein secreted by the prostate gland in men, both by normal as well as malignant cells.. It exists in two forms: free PSA and bound PSA (attached to certain proteins in the blood). PSA helps sperm move during ejaculation, and only a small amount is released into the blood. High PSA levels may signal an enlarged prostate, inflammation of the prostate, infection, or cancer. Low PSA levels do not always rule out that the disease is gone. 

The PSA (Prostate Specific Antigen) Total test is intended as the primary screening test to identify prostate cancer, along with other investigations like DRE or a biopsy.

What Do the Results Mean?

Pathological Factors 

Test Parameter

Interpretation (possible causes)

Low levels

  • Not a concern

High Levels

  • Increases in glandular size and tissue damage caused by benign prostatic hypertrophy

  • Prostatitis

  • Prostate inflammation

  • Prostate carcinoma

  • Prostate ischemia

Physiological Factors

🧓 Age: PSA levels naturally rise with age due to prostate enlargement.

💊 Medications: 5-alpha reductase inhibitors (e.g., finasteride) can lower PSA levels by about 50%.

Lifestyle Factors

🏃 Physical Activity: Recent ejaculation, vigorous exercise, cycling, or prostate examination can temporarily elevate PSA levels.

Disclaimer: This information is for educational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider for personalized guidance.

What Do Normal PSA Levels Mean?

Normal PSA levels usually indicate a healthy prostate without significant enlargement, infection, or malignancy.

What Do High Levels of PSA Indicate?

High PSA levels may suggest prostate cancer, inflammation, infection, or benign prostatic hyperplasia. Your doctor will recommend further evaluation to determine the cause.

What to Do if Your PSA Is Higher Than Normal?

If your PSA levels are higher than normal, your doctor may suggest repeat testing, free/total PSA ratio, DRE, MRI, or a prostate biopsy. Management will depend on the underlying condition.

What Do Low Levels of PSA Indicate?

Low PSA levels are generally normal.

Can PSA Results Be Inaccurate?

Yes, certain factors like recent ejaculation, urinary infection, prostate manipulation, or vigorous exercise can affect PSA readings.

What Factors Can Affect PSA Results?

Though it is a reliable test, some circumstances can influence accuracy:

  • Prostatitis 
  • Urinary infection
  • Prostate biopsy or surgery
  • Ejaculation or cycling within 48 hours
  • Benign prostatic enlargement
  • Older age
  • Medications (finasteride, dutasteride)
  • Obesity
  • Low testosterone levels

What Follow-Up Tests May Be Required?

If your PSA levels are elevated or abnormal, your doctor may recommend additional tests to identify the cause and confirm the diagnosis. These may include:

Table: Tests Commonly Ordered Alongside PSA Total Test

Test Name

Primary Purpose

Free PSA Test

Differentiates between benign and malignant causes

Free/ Total PSA ratio

Measures the total and active (free)PSA in the blood 

Digital Rectal Examination (DRE)

Physical examination of the prostate

Prostate MRI

Detects structural abnormalities

Biopsy

Confirms prostate cancer diagnosis

How Does the Total PSA Test Differ from Other Prostate Related Tests?

It is important to understand how the Total PSA (Prostate-Specific Antigen) test differs from other related tests used to evaluate prostate health:

  • Free PSA Test: Measures the unbound (free) form of PSA in the blood. The ratio of free to total PSA helps differentiate between benign prostate conditions (like prostatitis or benign prostatic hyperplasia) and prostate cancer.
  • PSA Reflex Test: Conducted automatically if total PSA levels are elevated. It includes additional assessments such as free PSA, PSA ratio, or PHI (Prostate Health Index) to help clarify whether the rise is due to benign or malignant causes, reducing unnecessary biopsies.
  • Digital Rectal Examination (DRE): A physical exam performed by a doctor to check the prostate gland for abnormalities such as lumps, nodules, or enlargement.
  • Prostate Biopsy: Recommended when PSA levels remain persistently high or imaging and reflex results suggest malignancy. It involves taking small tissue samples from the prostate to confirm the presence of cancer cells.

FAQs related to PSA (Prostate Specific Antigen) Total

PSA stands for prostate-specific antigen. It is protein produced by the cells of the prostate gland.
The PSA (Prostate Specific Antigen) Total test is a blood test that measures the total amount of PSA, a protein produced by the prostate gland that liquefies the semen in males. This test helps find out prostate inflammation, infection, enlarged prostate or prostate cancer in men.
A higher PSA level indicates a higher risk of prostate-related problems, such as prostate enlargement, urinary tract infection, or prostate inflammation. Always consult a doctor to understand your test results correctly.
The symptoms associated with high PSA levels are difficulty in urination, painful or frequent urination (particularly at night), blood in urine or semen, weak or interrupted flow of urine, difficulty holding urine, painful ejaculation, and persistent pain in the lower back, pelvis, or thighs.
If your reports suggest high PSA levels, your doctor may prescribe additional tests before considering a prostate biopsy. These tests are repeat PSA testing include digital rectal examination (DRE), free PSA test, PSA velocity test (indicating the rate at which PSA increases over time), PSA density test (indicating the PSA per volume of the prostate), PSA-based markers (like Prostate Health Index, 4K score), urinary markers, and magnetic resonance imaging (MRI) of the prostate.
Factors that can affect the PSA (Prostate Specific Antigen) Total test results include age, size of the prostate gland, physical activity such as cycling, exercise and sexual activity within 48 hours. Also, prostate infections or injuries, medical procedures (such as a biopsy etc.) and use of certain medicines (such as painkillers, finasteride etc.) may affect the test results.
Always consult your doctor if your test results show high PSA levels. Adopting lifestyle changes may help. Eat more proteins, tomatoes, and cruciferous vegetables; maintain a healthy weight and practice stress reduction techniques like yoga, meditation etc to manage stress as it is associated with high PSA levels and get enough Vitamin D.
Prostatomegaly refers to an enlarged prostate. Grade 1 prostatomegaly is generally considered mild enlargement, often associated with benign conditions like BPH (benign prostatic hyperplasia).
The average adult prostate is about the size of a walnut, weighing between 20 and 25 grams (g).
The price for this test can vary depending on the location and the laboratory.
You can book PSA (Prostate Specific Antigen) Total at any Tata 1mg lab near you. Simply check for the nearest lab location and schedule a convenient date and time for your test.

PSA (Prostate Specific Antigen) Total test price for other cities

Price inKolkataRs. 659
Price inBangaloreRs. 899
Price inNew DelhiRs. 799
Price inMumbaiRs. 879
Price inGurgaonRs. 799

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PSA (Prostate Specific Antigen) Total