PMOS (formerly PCOS) Package Advanced,

Polyendocrine Metabolic Ovarian Syndrome (PMOS), formerly known as PCOS, is a condition in which the body produces an imbalance of reproductive and metabolic hormones, particularly higher-than-normal androgen levels. These hormonal and metabolic changes can affect ovarian function, menstrual cycles, fertility, and overall health. PMOS can present with a wide range of features involving multiple body systems. Metabolic features include obesity, insulin resistance, prediabetes or type 2 diabetes, high blood pressure, abnormal lipid levels, fatty liver disease, cardiovascular risk, and sleep apnoea. Reproductive manifestations include irregular periods, ovulatory dysfunction, infertility, pregnancy-related complications, and increased risk of endometrial cancer. Psychological features may include anxiety, depression, poor quality of life, and eating disorders. Dermatological manifestations commonly include acne, excessive hair growth (hirsutism), and hair thinning or alopecia due to androgen excess. According to the World Health Organization (WHO), PCOS affects an estimated 8–13% of women of reproductive age, and up to 70% of cases are undiagnosed. Therefore, early diagnosis with the PMOS (formerly PCOS) Package Advanced, can aid in appropriate interventions and help prevent future complications.

The PMOS panel is designed to evaluate the endocrine, ovarian, and metabolic abnormalities associated with Polyendocrine Metabolic Ovarian Syndrome. HbA1c and HOMA-IR assess long-term glycemic status and insulin resistance, a central driver of metabolic dysfunction and androgen excess in PMOS. Lipid Profile evaluates dyslipidaemia and cardiometabolic risk. LH and FSH help assess neuroendocrine and ovulatory dysfunction, while AMH reflects ovarian reserve and disordered folliculogenesis commonly seen in PMOS. Total Testosterone, Free Testosterone, SHBG, and DHEAS evaluate biochemical hyperandrogenism and help identify ovarian and adrenal androgen excess contributing to acne, hirsutism, alopecia, and menstrual irregularities. Serum Prolactin is included to exclude hyperprolactinemia as a cause of menstrual and ovulatory disturbances. 17 Alpha Hydroxy Progesterone helps rule out non-classical congenital adrenal hyperplasia and other adrenal causes of hyperandrogenism. Thyroid Profile (FT3, FT4, and TSH) assesses thyroid dysfunction, which may mimic or worsen reproductive and metabolic abnormalities associated with PMOS.

You may get this test if you show symptoms suggestive of PMOS, such as irregular periods, abnormal hair growth, weight gain, hair loss, skin conditions such as acne, etc. It may also be  done in individuals with risk factors for the condition, such as family history or obesity. Additionally, this package helps monitor treatment response in women already undergoing treatment for PMOS.

An overnight fasting (8 to 12 hours) is required, along with other preparations depending on the number of tests included in this package. You are required to submit all the samples that are  part of this package during the sample collection itself. Additionally, inform your doctor about any medications or supplements that you may be taking before undergoing for the PMOS (formerly PCOS) Package Advanced, as few of them may affect your test results, potentially requiring adjustments or temporary discontinuation before the test.

Talk to your doctor about your specific test results. The doctor might ask you to get additional tests done to determine the severity of your condition. After analyzing all th