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Islet Cell Antibody - 512

Islet Cell Antibody - 512

Also referred as
Islet Cell Antibody ICA-512
Protein Tyrosine Phosphatase-Like Protein Antibody test
IA-2 Antibody test
For men & women
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288 hours
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The Islet Cell Antibody - 512 test is a blood test that measures autoantibodies against pancreatic islet cells. These antibodies indicate autoimmune activity that may damage insulin-producing beta cells and are primarily used in the diagnosis and prediction of type 1 diabetes (T1D).

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Understanding Islet Cell Antibody - 512

Islet cell antibodies (ICA) are autoantibodies produced by the immune system that target the islet cells in the pancreas, which contain insulin-producing beta cells. A specific target of these antibodies is ICA-512, also known as protein tyrosine phosphatase-like protein IA-2, a protein found in the beta cells. In type 1 diabetes, the immune system mistakenly attacks these cells, leading to insulin deficiency.

The Islet Cell Antibody - 512 test measures the levels of ICA autoantibodies in the blood. Elevated ICA-512 antibodies can often be detected years before clinical symptoms appear. This makes the test useful for identifying individuals at risk of developing type 1 diabetes. 

This test is particularly recommended for those with high blood sugar, unexplained weight loss, frequent urination, excessive thirst, or a family history of autoimmune diabetes. The test is also valuable for monitoring disease progression in diagnosed patients, screening high-risk individuals with other autoimmune or genetic conditions, distinguishing type 1 diabetes from type 2 diabetes, and identifying other autoimmune disorders associated with elevated ICA-512 levels, such as autoimmune thyroid disease or celiac disease.

No special preparation is needed for getting the Islet Cell Antibody - 512 test done. However, be sure to inform the doctor about any medications or supplements being taken, as they may affect the test results. 

Lab test results may vary across different laboratories. Abnormal test results require expert interpretation. Therefore, never try to self-medicate based solely on these results. Always consult a doctor for a proper understanding of the test results.

Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.

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What does Islet Cell Antibody - 512 measure?

The Islet Cell Antibody - 512 test measures autoantibodies that target the ICA-512 protein in pancreatic islet cells. A positive or elevated result indicates autoimmune activity against beta cells, which can reduce insulin production and lead to high blood sugar levels. High ICA-512 levels suggest an increased risk of developing type 1 diabetes or reflect ongoing autoimmune destruction in patients who have already been diagnosed. In contrast, low or absent levels are generally seen in healthy individuals or in those with type 2 diabetes, where autoimmunity is not the primary cause. Monitoring ICA-512 levels alongside other diabetes-related autoantibodies provides a comprehensive understanding of autoimmune activity and helps assess the risk of insulin dependence.

FAQs related to Islet Cell Antibody - 512

The Islet Cell Antibody - 512 test is a blood test that detects autoantibodies targeting the pancreatic islet cells, specifically the ICA-512 protein. It helps identify autoimmune activity that may damage insulin-producing beta cells and is primarily used in the diagnosis and prediction of type 1 diabetes.
It is recommended to assess the risk of developing type 1 diabetes, aid in diagnosing type 1 diabetes in symptomatic individuals, screen high-risk people (e.g., with a family history or other autoimmune conditions), monitor disease progression, distinguish type 1 from type 2 diabetes, and detect associated autoimmune disorders such as thyroid disease or celiac disease.
High ICA-512 levels suggest an increased risk of developing type 1 diabetes or ongoing autoimmune destruction in diagnosed patients. Abnormal results should always be interpreted by a healthcare professional in the context of symptoms and other test results.
No fasting is required for the Islet Cell Antibody - 512 test.
No special preparation is needed. However, inform your doctor about any medications or supplements you are taking, as some may affect the results.
A blood sample is collected, usually from a vein in the arm, and sent to a lab for analysis.
The frequency depends on your health status and your doctor’s recommendation. For individuals diagnosed with type 1 diabetes, regular testing may be advised to monitor disease progression and evaluate treatment effectiveness.
Yes, type 1 diabetes is autoimmune, so ICA-512 antibodies are typically present, whereas type 2 diabetes usually does not involve autoimmune activity.
High levels indicate autoimmune activity. Consult your doctor for further evaluation, monitoring, and guidance on risk management or treatment options.
The ICA-512 test is often used alongside other diabetes-related autoantibody tests, such as the Insulin Antibody Type I & II test and the Glutamic Acid Decarboxylase (GAD) Autoantibodies test. Together, these tests provide a more complete assessment of an individual’s risk of developing type 1 diabetes.
Type 1 diabetes has a genetic component and can run in families. However, having anti-islet cell antibodies does not necessarily mean a person will develop the disease. It indicates a risk, not a certainty.
Healthy individuals usually do not have anti-islet cell antibodies. If these antibodies are detected in a healthy person, it may suggest an early autoimmune response and a potential risk for type 1 diabetes.
Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.
Content created by
Written by:
Dr. Lipika Khurana
PGDHHM, BDS
Reviewed by:
Dr. Swati Gupta (Anand)
MBBS, MD Lab Medicine
Want to know moreRead our editorial policy
Last Updated12th Jul 2026

Islet Cell Antibody - 512 test price for other cities

Price inBangaloreRs. 2299
Price inDehradunRs. 2050
Price inNew DelhiRs. 2069
Price inMumbaiRs. 2389
Price inKolkataRs. 1939

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Islet Cell Antibody - 512