
Amoebic Serology, IgG









The Amoebic Serology, IgG is a blood test that detects IgG antibodies against Entamoeba histolytica, a parasite that causes amoebiasis (amoebic dysentery). In this test, antibodies against amoebiasis are detected as confirmation of the infection. It is done to differentiate amoebiasis from other infections and to distinguish between active and past infections.













Understanding Amoebic Serology, IgG
Amoebiasis is a parasitic infection that affects the intestines and occasionally other organs. It primarily spreads in the body through contaminated potable water that contains the microorganism, consuming infected fruit and uncooked vegetables, engaging in unprotected oral-anal sexual contact, or coming into contact with dirty hands or objects in unsanitary or unhygienic surroundings. Once ingested, the parasite’s cysts enter the small intestine, and the symptoms begin to appear in a couple of weeks.
The Amoebic Serology, IgG test is recommended for individuals experiencing persistent diarrhea, abdominal pain, and weight loss, especially if they have traveled to tropical or subtropical regions. It can also be done for those with intestinal abscesses, inflammation, liver abscesses, and immunocompromised individuals. Additionally, this test can be advised for individuals exposed to contaminated water or food, or those with a history of amoebiasis. Moreover, it can be done for individuals with an unclear diagnosis and abdominal symptoms that persist even after the treatment.
No special preparation is required for this test. However, inform the doctor about all the medications or supplements being taken, as these may affect the test results, potentially requiring adjustments or temporary discontinuation. Narrate the complete medical history to help the doctor relate the clinical and laboratory findings.
Lab test results may vary across laboratories. Do not self-medicate. Always consult the doctor to understand the test results correctly. The insights from Amoebic Serology, IgG test will help doctors formulate the overall treatment plans.
What does Amoebic Serology, IgG measure?
The Amoebic Serology, IgG test measures the presence of specific immune proteins, known as IgG antibodies, in the blood. These antibodies are produced in response to an infection with Entamoeba histolytica. They become detectable a few weeks after infection onset and can remain in the blood for long after the infection has cleared, indicating previous exposure to the parasite.
The insights from this test help understand the risk of amoebiasis-related complications and help doctors formulate treatment strategies if an active infection is suspected. Additionally, it enables infected individuals to take proactive measures in managing their gastrointestinal health and mitigating potential risks associated with the infection.





FAQs related to Amoebic Serology, IgG
- Entamoeba Histolytica Antibody [Internet]. Rochester, NY: University of Rochester Medical Center; [Accessed 24 Oct. 2024]. Available from:
- Leo M, Haque R, Kabir M, Roy S, Lahlou RM, Mondal D, Tannich E, Petri WA Jr. Evaluation of Entamoeba histolytica antigen and antibody point-of-care tests for the rapid diagnosis of amebiasis. J Clin Microbiol. 2006 Dec;44(12) :4569-71. [Accessed 24 Oct. 2024]. Available from:
- Chou A, Austin RL. Entamoeba histolytica Infection. [Updated 2023 Apr 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from:
- Sathar MA, Bredenkamp BL, Gathiram V, Simjee AE, Jackson TF. Detection of Entamoeba histolytica immunoglobulins G and M to plasma membrane antigen by enzyme-linked immunosorbent assay. J Clin Microbiol. 1990 Feb;28(2) :332-5. [Accessed 24 Oct. 2024]. Available from:
- Zulfiqar H, Mathew G, Horrall S. Amebiasis. [Updated 2023 Jun 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from:
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