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MRP: Rs. 55 for 1 strip(s) (10 tablets each)
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Composition for ZOLSOMA

Melatonin(3 mg),Zolpidem(5 mg)

food interaction for ZOLSOMA

alcohol interaction for ZOLSOMA

pregnancy interaction for ZOLSOMA

lactation interaction for ZOLSOMA

There is no data available. Please consult doctor before consuming the drug.
Zolsoma 3 mg/5 mg tablet may cause excessive drowsiness and calmness with alcohol.
Taking melatonin with alcohol may cause sleepiness and the effects may become even stronger.
Zolsoma 3 mg/5 mg tablet is probably safe to use during pregnancy.
Either animal studies have shown no adverse effect on the fetus, but there is no human studies or animal studies have shown an adverse effect that was not confirmed in human studies. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Melatonin(3 mg)


To treat primary sleep disturbances (persistent difficulty in falling asleep or staying asleep or poor quality of sleep, that has no apparent cause) for a short time.

How it works

Melatonin belongs to group of hormones that are naturally produced in the body. It promotes sleep by setting natural biological clock of the body.

Common side effects

Rash, Nervousness, Mood swings, Headache, Nausea, Nightmare, Decreased red blood cell count, Blurred vision, Night sweats, Abnormal liver function tests, Increased bilirubin in the blood, Visual impairment, Increased blood pressure, Depression, Dry mouth, Fainting, Vertigo, Palpitations, Protein in urine, Chest pain, Indigestion, Anxiety, Dizziness, Stomach pain, Itching, Weakness, Sleepiness, Migraine, Increase in body weight, Blood in urine, Increased glucose in urine, Loss of consciousness, Insomnia, Fatigue, Disorientation (alteration of mental status), Dry skin, Irritation, Psoriasis
Zolpidem(5 mg)


Zolpidem is used to treat sleep problems such as difficulty falling asleep, waking in the middle of the night, waking too early in adults that are causing distress and affecting every day life.

How it works

Zolpidem belongs to a group of drugs called hypnotics and sedatives. It works by slowing activity in the brain to help you sleep.

Common side effects

Nightmare, Allergic reaction, Redness of skin, Balance disorder (loss of balance), Constipation, Diarrhoea, Dizziness, Drowsiness, Dry mouth, Fatigue, Flatulence, Headache, Heartburn, Nausea, Stomach pain


No substitutes found

Expert advice for ZOLSOMA

  • Do not drive or use machinery after taking melatonin since it can make you feel drowsy.
  • Smoking may make melatonin less effective since it can increase the metabolism (breakdown) of melatonin by the liver.
  • Alcohol reduces the effectiveness of melatonin so must be avoided before, during or after taking melatonin.
  • Do not take melatonin if you are allergic to melatonin or any of the other ingredients of this medicine.
  • Do not take melatonin if you are suffering from liver or kidney problems; if you have intolerance to some sugars; or have been suffering from an autoimmune disease (where the body is ‘attacked’ by its own immune system).

Frequently asked questions for ZOLSOMA


Q. Is melatonin safe/ safe for kids?
Melatonin is safe when taken at prescribed dose and duration as advised by your doctor. It is however not recommended for use in children.
Q. Can I take melatonin for a nap?
Melatonin is to be taken if you have persistent difficulty in falling asleep or staying asleep or poor quality of sleep, that has no apparent cause. It should not be used for naps. Use should be strictly as per doctor’s advice.
Q. Is melatonin addictive or habit forming?
No. Melatonin doesn’t have addictive or habit forming potential as long as it is taken as advised by doctor.
Q. Can I take melatonin with Ambien/ Zoloft/ Prozac/ Lexapro/ prednisone/ Nyquil/Advil/ Klonopin/ Cymbalta/ wine?
Melatonin increases the calming or sleep inducing effects of Ambien (Zolpidem), Prozac (fluoxetine) and Klonopin (clonazepam). No major interactions are reported during usage of melatonin and Zoloft (sertraline)/ Lexapro (escitalopram)/ prednisone/ Nyquil (acetaminophen, dextromethorphan, doxylamine and pseudoephedrine)/ Advil (ibuprofen)/ Cymbalta (duloxetine). Alcohol in wine reduces the sleep inducing effect of melatonin.
Q. Is melatonin a hormone?
Melatonin is a natural, non-addicting hormone supplement that helps induce sleep by setting biological clock of the body.
Q. Is melatonin available in India?
Yes, melatonin is available in India.
Q. Can I take melatonin for an insomnia/ anxiety?
Melatonin has been indicated for the treatment of insomnia (sleeplessness) but not anxiety.
Q. Can I take melatonin for long periods of time?
Melatonin should be taken only for a period of 3 months (13 weeks) at a time. Further use should be strictly as per the doctor’s advice.
Q. Does melatonin cause headaches/ constipation/ cancer/ acne?
Melatonin causes headaches and constipation in some patients. No data is available on whether it causes cancer or acne.
Q. Does melatonin expire?
Like other medications, melatonin also expires. Expiry date is printed on medicine package/box, beyond which the medicine should not be used.


Q. Is zolpidem/ Ambien a benzodiazepine or a controlled drug or an opiate?
No. Zolpidem is sedative-hypnotic, used to treat sleep problems. Ambien is a brand containing zolpidem as active ingredient.
Q. Can I take zolpidem with hydrocodone/ Benadryl (diphenhydramine)/ Xanax (alprazolam)/ Nyquil (paracetamol, dextromethorphan, doxylamine )/ lorazepam/ ibuprofen/ citalopram?
Zolpidem may cause excessive drowsiness, sleepiness, breathing difficulty and difficulty performing rutine as well as skilful activities if taken with either of hydrocodone/ Benadryl (diphenhydramine)/ Xanax (alprazolam)/ Nyquil (paracetamol, dextromethorphan, doxylamine )/ lorazepam/ citalopram. Do not take zolpidem with these drugs. Zolpidem has no known interactions with ibuprofen. Always consult your doctor before consuming any drug concomitantly with zolpidem.
Q. Can I take zolpidem with prednisone?
No results found for any interaction of zolpidem with prednisone, but always consult with your doctor before taking this medication.
Q. Does zolpidem make you high?
Zolpidem produces a calming effect on the brain and induces sleep. This calming effect may be perceived as pleasant or feeling high by some individuals. On prolonged use, zolpidem may also make an individual dependent such that they are not be able to sleep or function normally without taking it.
Q. Does zolpidem raise blood pressure/ cause headaches/ weight loss?
Headache is a common side-effect of zolpidem. Zolpidem has not been reported to have any effect on blood pressure or weight.
Q. Does zolpidem have acetaminophen or asprin in it?
No, zolpidem does not have acetaminophen or asprin in it.
Q. Does zolpidem help with anxiety?
Zolpidem is used to treat insomnia, which may help ease anxiety in some patients, although doctors do not prescribe zolpidem for anxiety alone because it does not work in the same manner as other sedatives anti-anxiety drugs.
Q. Does zolpidem expire?
Like all medicines, zolpidem has an expiry date, which is printed on the tablet strip or bottle. Zolpidem should not be taken beyond this date.


Content on this page was last updated on 28 April, 2015, by Dr. Varun Gupta (MD Pharmacology)