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Composition for ZAPSPAS

Dicyclomine(20 mg),Nimesulide(100 mg)

food interaction for ZAPSPAS

alcohol interaction for ZAPSPAS

pregnancy interaction for ZAPSPAS

lactation interaction for ZAPSPAS

It is better to take Zapspas 20mg/100mg tablet with food.
Interaction with alcohol is unknown. Please consult your doctor.
Zapspas 20mg/100mg tablet is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Dicyclomine(20 mg)


Dicyclomine is used to treat periodic spasms and pain in abdomen and stomach, intestinal cramps, irritable bowel syndrome (disorder of the intestines that leads to cramps in the abdomen, gas, bloating and changes in bowel habits) and inability to control urine (urinary incontinence).

How it works

Dicyclomine belongs to antispasmodic and anticholinergic (antimuscarinic) class of medicines that act by relieving the smooth muscle tightening (contraction) of the gastrointestinal tract via dual action: (i) by a specific action (anticholinergic), which reduces muscle contractions and (ii) by a direct effect on muscles of the stomach and intestine (musculotropic) leading to muscle relaxations, and decrease in contraction and pain.

Common side effects

Flatulence, Abdominal bloating, Blurred vision, Gastrointestinal discomfort, Constipation, Dizziness, Drowsiness, Weakness, Dry mouth, Difficulty in urination, Headache, Loss of appetite, Stomach pain, Vomiting
Nimesulide(100 mg)


Nimesulide is used to treat acute pain, osteoarthritis (pain and swelling of joints due to degeneration) and pain during periods.

How it works

Nimesulide belongs to a class of medications called non-steroidal anti-inflammatory drugs (NSAIDs) which works by blocking the production of prostaglandins (a chemical associated with pain) thereby relieving pain and inflammation.

Common side effects

Nausea, Rash, Abnormal blood cell count, Anemia, Constipation, Diarrhoea, Dizziness, Shortness of breath, Gastritis, Hypersensitivity reaction, Increased blood pressure, Swelling, Increased sweating, Itching, Liver enzyme increased, Vomiting


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Expert advice for ZAPSPAS

  • This medication may impair your thinking or alertness. Be careful if you drive or do anything that requires you to be alert.
  • Avoid becoming overheated or dehydrated during exercise and in hot weather. Dicyclomine can decrease your sweating, which can lead to heat stroke in a hot environment.
  • Avoid taking alcohol as it can increase certain side effects of dicyclomine.
  • Stop using dicyclomine and call your doctor right away if you have serious side effects such as confusion, hallucinations, unusual thoughts or behavior, fast or uneven heart rate, or if you urinate less than usual or not at all.

Frequently asked questions for ZAPSPAS


Q. Is Dicyclomine safe?
Dicyclomine is safe if used at prescribed doses for the prescribed duration as advised by your doctor.
Q. Is Dicyclomine gluten free?
Dicyclomine active drug does not contain gluten. Read the label instruction of the brands your doctor prescribes you, for gluten content.
Q. Is Dicyclomine an over-the-counter medicine?
Dicyclomine is available over-the-counter. However, always consult your doctor before taking dicyclomine for your disease.
Q. Does dicyclomine help nausea?
Dicyclomine is not known to relieve nausea. Nausea is a common side effect of dicyclomine.
Q. Does dicyclomine help constipation or trigger constipation?
Dicyclomine may cause constipation.
Q. Is dicyclomine an opiate/steroid/antacid/NSAID/benzodiazepine?
Dicyclomine is not an opiate, steroid, or an antacid. It is neither a NSAID not a benzodiazepine.
Q. Is dicyclomine a muscle relaxer?
Yes, dicyclomine is a smooth muscle relaxant. It has a direct effect on muscles of the stomach and intestine. It does not relax the skeletal/voluntary muscles.
Q. Can I take dicyclomine for diarrhea?
Dicyclomine has no known effects in treating diarrhea.
Q. Can I take dicyclomine for menstrual cramps?
Dicyclomine mainly acts on the smooth muscles of the intestine. Hence, it is used to relieve cramps or spasms of the stomach and intestines (gut). It is not known whether it can be used for menstrual cramps.
Q. Does dicyclomine cause constipation?
Dicyclomine may cause constipation.
Q. Does dicyclomine make you drowsy?
Dicyclomine may cause drowsiness and make you feel sleepy.
Q. Does dicyclomine cause hair loss?
Dicyclomine does not have hair loss as a known side-effect.
Q. Can I take dicyclomine with Advil (ibuprofen)/ amoxicillin/ Pepto (bismuth subsalicylate)/ tramadol/ Vicodin (acetaminophen and hydrocodone)/ oxycodone/ Tylenol (paracetamol)?
There are no known serious drug interactions between dicyclomine and Advil (ibuprofen)/ amoxicillin/ Pepto (bismuth subsalicylate)/ Tramadol/ Vicodin (acetaminophen and hydrocodone)/ oxycodone/ Tylenol (paracetamol). Dicyclomine is often available in combination with pain killers like paracetamol Consult your doctor about all medications currently taken before starting and while on dicyclomine.


Q. Is Nimesulide an antibiotic?
No, Nimesulide is non-steroidal anti-inflammatory drug (NSAIDs; pain-relieving drug) which relieves acute pain in conditions like joint pain and period pain. However, it may be used with antibiotics to relieve pain associated with certain infections.
Q. Can I take Nimesulide with paracetamol or ibuprofen?
Nimesulide, paracetamol and ibuprofen are non-steroidal anti-inflammatory drugs (NSAIDs; pain-relieving drugs). Taking two NSAID drugs together is not advisable as it may increase the potential for gastric ulceration and bleeding.
Q. Does Nimesulide contain aspirin or sulphur?
No. Nimesulide is a non-steroidal anti-inflammatory drug (NSAIDs; pain-relieving drug) doesn’t contain aspirin or sulphur.
Q. Is Nimesulide safe?
Nimesulide is safe at prescribed dose and duration as advised by your doctor.


Content on this page was last updated on 22 May, 2015, by Dr. Varun Gupta (MD Pharmacology)