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Yondelis Injection

Trabectedin (1mg)
Genuine
Authenticity Assured
Prescription
required
Yondelis Injection is used in the treatment of some kinds of cancers. It is used in patients with advanced soft tissue sarcoma when previous medicines have been unsuccessful. It is also used with other medicines as part of combination therapy to treat ovarian cancer that has come back.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 23 Sep 2025 | 05:10 PM (IST)
₹113834 MRP ₹124968.759% off 
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General Information

The content is shown in English
Yondelis Injection image
Yondelis Injection image

Product introduction

Yondelis Injection is given as an injection under the medical supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include headache, fatigue, vomiting, weakness and increased liver enzyme. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver and kidney. Generally, avoid alcohol consumption while on treatment.

Before taking it, tell your doctor if have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using.This medicine is not recommended during pregnancy or while breastfeeding. Use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Yondelis Injection

Benefits of Yondelis Injection

Soft tissue sarcoma
Soft tissue sarcoma is a rare type of cancer that begins in the body's connective tissues, such as muscles, fat, blood vessels, or nerves. It can occur anywhere in the body and may not show symptoms until it grows or spreads, making it harder to treat in later stages. Yondelis Injection is used when the disease does not respond well to standard chemotherapy. It works by interfering with the DNA inside cancer cells, helping slow down or stop their growth. This can help reduce tumor size, delay disease progression, and relieve symptoms like pain or swelling, ultimately improving the patient's daily functioning and quality of life.

Side effects of Yondelis Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Yondelis
  • Headache
  • Fatigue
  • Vomiting
  • Weakness
  • Nausea
  • Increased liver enzymes
  • Low blood platelets
  • Increased creatine phosphokinase (CPK) level in blood
  • Decreased white blood cell count (neutrophils)
  • Decreased appetite
  • Constipation

How to use Yondelis Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Yondelis Injection works

Yondelis Injection belongs to class of drugs called alkylating agents. It works by sticking to the DNA in cells and damaging it. This stops the cancer cells growing and multiplying.

Quick tips

  • Yondelis Injection is given as an intravenous infusion (IV infusion) under the supervisión of a doctor.
  • Do not skip any dose and complete the course as suggested by your doctor.
  • Use an effective method of birth control to avoid pregnancy while taking this medication.
  • Inform your doctor if you notice yellowing of eyes or skin, dark urine, muscle pain and skin rash.
  • Your doctor may get regular blood tests done to monitor your blood cell count, platelet count and liver function.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Yondelis Injection.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Information regarding the use of Yondelis Injection during pregnancy is not available. Please consult your doctor.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Yondelis Injection during breastfeeding is not available. Please consult your doctor.
Driving

Driving

UNSAFE
Yondelis Injection may cause side effects which could affect your ability to drive.
Yondelis Injection may make you feel tired and experience a loss of strength which may affect your ability to drive.
Kidney

Kidney

CAUTION
Yondelis Injection should be used with caution in patients with kidney disease. Dose adjustment of Yondelis Injection may be needed. Please consult your doctor.
Liver

Liver

CAUTION
Yondelis Injection should be used with caution in patients with liver disease. Dose adjustment of Yondelis Injection may be needed. Please consult your doctor.

Interaction with drugs

Taking Yondelis with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Do not use Trabectedin with Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted).
Severe

Cholera Vaccine (Inactivated) (Oral Route)

Do not use Trabectedin with Cholera Vaccine (Inactivated).
Severe

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Do not use Trabectedin with Purified Vi Polysaccharide Typhoid Vaccine.
Severe

Indinavir (Oral Route)

Indinavir may raise blood levels of Trabectedin. Indinavir may raise blood levels of Trabectedin.
Severe

Itraconazole (Oral Route)

Itraconazole may raise blood levels of Trabectedin. Itraconazole may raise blood levels of Trabectedin.

Fact Box

Chemical Class

Benzazocine Derivative

Habit Forming

No

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Other Anticancer Agents

References

  1. Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1719-20.
  2. Trabectedin. Hertford, Herts: Immedica; 2007 [revised Jun. 2018]. [Accesed 27 Mar. 2019] (online) Available from:
  3. Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Janssen Pharmaceuticals
Address: Johnson & Johnson Private Limited., 501 Arena Space, Behind Majas Bus Depot, Off Jogeshwari Vikhroli Link Road, Jogeshwari (E), Mumbai 400 060

Vendor Details

Country of origin: India
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