


Yondelis Injection
Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 23 Sep 2025 | 05:10 PM (IST)

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General Information



Product introduction
Yondelis Injection is given as an injection under the medical supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include headache, fatigue, vomiting, weakness and increased liver enzyme. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver and kidney. Generally, avoid alcohol consumption while on treatment.
Before taking it, tell your doctor if have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using.This medicine is not recommended during pregnancy or while breastfeeding. Use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Yondelis Injection
Benefits of Yondelis Injection
Soft tissue sarcoma is a rare type of cancer that begins in the body's connective tissues, such as muscles, fat, blood vessels, or nerves. It can occur anywhere in the body and may not show symptoms until it grows or spreads, making it harder to treat in later stages. Yondelis Injection is used when the disease does not respond well to standard chemotherapy. It works by interfering with the DNA inside cancer cells, helping slow down or stop their growth. This can help reduce tumor size, delay disease progression, and relieve symptoms like pain or swelling, ultimately improving the patient's daily functioning and quality of life.
Side effects of Yondelis Injection
- Headache
- Fatigue
- Vomiting
- Weakness
- Nausea
- Increased liver enzymes
- Low blood platelets
- Increased creatine phosphokinase (CPK) level in blood
- Decreased white blood cell count (neutrophils)
- Decreased appetite
- Constipation
How to use Yondelis Injection
How Yondelis Injection works
Quick tips
- Yondelis Injection is given as an intravenous infusion (IV infusion) under the supervisión of a doctor.
- Do not skip any dose and complete the course as suggested by your doctor.
- Use an effective method of birth control to avoid pregnancy while taking this medication.
- Inform your doctor if you notice yellowing of eyes or skin, dark urine, muscle pain and skin rash.
- Your doctor may get regular blood tests done to monitor your blood cell count, platelet count and liver function.
Safety advice

Alcohol

Pregnancy

Breast feeding

Driving
Yondelis Injection may make you feel tired and experience a loss of strength which may affect your ability to drive.

Kidney

Liver
Interaction with drugs
Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)
Cholera Vaccine (Inactivated) (Oral Route)
Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)
Indinavir (Oral Route)
Itraconazole (Oral Route)
Fact Box
Chemical Class
Habit Forming
Therapeutic Class
Action Class
References
- Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1719-20.
- Trabectedin. Hertford, Herts: Immedica; 2007 [revised Jun. 2018]. [Accesed 27 Mar. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:




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Address: Johnson & Johnson Private Limited., 501 Arena Space, Behind Majas Bus Depot, Off Jogeshwari Vikhroli Link Road, Jogeshwari (E), Mumbai 400 060
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Lab tests offered by us
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- PPBS (Postprandial Blood Sugar)
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid -19 test- RT PCR
- LFT (Liver Function Test)
- KFT (Kidney Function Test)
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid, Serum
- Vitamin B12
- CRP (C-Reactive Protein), Quantitative
- Urine C/S (Urine Culture and Sensitivity)
- Serum Electrolytes
- Serum Calcium
- Serum Creatinine
- Diabetes Screening (HbA1C & Fasting Sugar)
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hb (Hemoglobin)
- Complete Hemogram (CBC & ESR)














