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Varcolate Injection

Glycopyrrolate (0.2mg)
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Varcolate Injection is an anticholinergic medication. It is used before or even during an operation to reduce secretions and it even reverses the unwanted effects of certain medicines used during surgery (muscle relaxants). It also helps to treat peptic ulcers when oral medication is not tolerated.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 14 Apr 2026 | 04:20 PM (IST)
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10 ml Injection
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General Information

The content is shown in English
Varcolate Injection image
Varcolate Injection image

Product introduction

Varcolate Injection is given by your doctor or nurse. Let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen.

The most common side effects of this medicine include dry mouth, urinary retention, blurred vision, photophobia, dilation of the pupil, cycloplegia, increased heart rate, increased eye pressure, tachycardia, bradycardia, palpitation, and reduced sweating. Avoid drinking alcohol while taking this medicine as it can worsen your sleepiness.

Inform your doctor if you have glaucoma, myasthenia gravis, heart failure, and high blood pressure.

Uses of Varcolate Injection

Benefits of Varcolate Injection

General Anaesthesia
Varcolate Injection is used before and during surgery to reduce secretions of the mouth, throat, or stomach, such as saliva, stomach acid, or to prevent problems related to heart rhythm during anesthesia, intubation, or surgery. It also helps decrease the unwanted effects that may be caused by certain medicines like, neostigmine, pyridostigmine, etc. It is given by a specialist doctor called an anesthetist in a hospital setup.
Peptic ulcer disease
Peptic ulcer disease is a condition in which painful sores or ulcers develop in the inner lining of the stomach or gut (intestine). Varcolate Injection reduces the amount of acid your stomach makes which prevents further damage to the ulcer as it heals naturally. You may be given other medicines along with this medicine depending on what caused the ulcer.

Side effects of Varcolate Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Varcolate
  • Blurred vision
  • Dilatation of pupil
  • Palpitations
  • Reduced sweating
  • Urinary retention
  • Cycloplegia (paralysis of the ciliary muscle of the eye)
  • Ocular hyperemia
  • Slow heart rate
  • Increased heart rate
  • Increased intraocular pressure

How to use Varcolate Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Varcolate Injection works

Varcolate Injection is an anticholinergic medication. It works by blocking the activity of a chemical messenger (acetylcholine) in the brain.

Quick tips

  • Varcolate Injection is used before an operation, to reduce saliva and other secretions and to make the stomach contents less acidic.
  • It may also be used to reduce side effects of muscle-relaxing drugs and to prevent of slowing of heart beat during surgery.
  • It is given as an injection into a muscle or into a vein. 
  • Use caution while driving or doing anything that requires concentration as Varcolate Injection may cause dizziness and blurred vision.
  • You have been prescribed Varcolate Injection to reduce excessive drooling or salivation.
  • Take it at least 1 hour before or 2 hours after a meal.
  • It may cause constipation. Eat adequate fiber in your diet and drink plenty of water.
  • Use caution while driving or doing anything that requires concentration as Varcolate Injection may cause dizziness and blurred vision.
  • It may make you sweat less. Avoid doing things that may cause you to overheat such as exercise.
  • Inform your doctor if you develop nausea, vomiting, constipation or diarrhea that does not go away.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Varcolate Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Varcolate Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Varcolate Injection during breastfeeding is not available. Please consult your doctor.
Long-term use of Varcolate Injection might reduce milk production.
Driving

Driving

UNSAFE
Varcolate Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Varcolate Injection may affect vision and coordination. This may affect your driving ability.
Kidney

Kidney

CAUTION
Varcolate Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Varcolate Injection in patients with liver disease.

Frequently asked questions

No, Varcolate Injection is not a narcotic.
Yes, Varcolate Injection has its action on the heart which increases the heart rate (tachycardia). This property of the medication is utilized during surgery to prevent the fall of heart rate due to various other supplemental anesthetic medications.
Yes, Varcolate Injection can cause constipation because of its action on the intestine. It decreases the intestinal secretions and also decreases the gut motility which can result in constipation.
Yes, Varcolate Injection can sometimes lead to an increase in blood pressure. There are evidences where it has led to increased blood pressure. Therefore, when injected into a patient during a surgery, the heart rate and blood pressure are continuously monitored.
Some classes of antidepressant medicines can worsen the side effects of Varcolate Injection and cause uneasiness for the patient. These antidepressant medicines may include tricyclic antidepressants (amitriptyline or imipramine), phenelzine, tranylcypromine, clozapine, etc. Therefore, do inform your doctor about your previous illness and the medicines you are taking before you take this medication. Your doctor may make the necessary adjustments.

Fact Box

Chemical Class

Quaternary ammonium compounds

Habit Forming

No

Therapeutic Class

GASTRO INTESTINAL

Action Class

Anticholinergics- Anaesthetics
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Varenyam Healthcare Pvt Ltd
Address: 2, Vitrag Appartment, Karelibaug, Vadodara-390018, Gujarat, INDIA

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Varcolate Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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