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Glycopyrrolate is used before surgery to reduce secretions of saliva in mouth, throat and airways, acid in stomach; to reduce side effects of muscle-relaxing drugs and to prevent of slowing of heart beat during surgery. It is also used to reduce the drooling of saliva in patients (3-16 years of age) with cerebral palsy (a permanent movement disorder occurring in early childhood).

How it works

Glycopyrrolate belongs to a class of medications called anticholinergics. It decreases the secretions in the mouth, throat, airways and stomach acid.

Common side effects

Nervousness, Loss of sense of taste, Confusion, Constipation, Diarrhoea, Dizziness, Weakness, Drowsiness, Dry mouth, Difficulty in swalloing, Shortness of breath, Difficulty in urination, Abdominal bloating, Headache, Reduced sweating, Insomnia, Stomach upset, Vision disorder, Vomiting


Expert advice

  • Inform your doctor if you have any heart disease, heart failure, irregular heartbeats or high blood pressure as glycopyrrolate is known to increase the heart rate (tachycardia).
  • Glycopyrrolate should be used with caution if you have medical conditions such as myasthenia gravis (progressive neuromuscular disease characterized by weak muscles and unusual tiredness), glaucoma (increased pressure in the eye that causes vision problem), overactive thyroid gland, enlarged prostate gland, obstruction of the stomach or bowel causing vomiting  abdominal pain, chronic constipation and swelling.
  • Glycopyrrolate should be used with special precautions in case of fever as it may worsen the condition.
  • Avoid alcohol or any medication that may cause drowsiness. 
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.
  • Do not take if allergic to glycopyrrolate or any of its ingredients.

Frequently asked questions


Q. Is glycopyrrolate used for excessive sweating?
Glycopyrrolate is the most commonly used medicine for managing excessive sweating due to its anti-secretory or anticholinergic effect. 
Q. Is glycopyrrolate the same as glycopyrronium bromide?
Yes, glycopyrrolate is same as glycopyrronium bromide.
Q. Does glycopyrrolate affect fertility & birth control?
No, glycopyrrolate is not known to impair fertility and has no known effects on birth control.
Q. Is glycopyrrolate over the counter?
No, glycopyrrolate is strictly prescribed by the doctors.

Content on this page was last updated on 03 October, 2016, by Dr. Varun Gupta (MD Pharmacology)