Unifolin 15mg Tablet

Calcium Leucovorin (15mg)

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Unifolin 15mg Tablet is used to prevent the harmful effects of methotrexate (anticancer medicine). It is also used in the treatment of methotrexate overdose.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 09 Aug 2026 | 01:06 AM (IST)

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General Information

Storage

Store below 30°C

The content is shown in English

Product introduction

Unifolin 15mg Tablet can be taken with or without food. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects.

It is generally safe medicine to use with no common side effects if taken in the right amount. Your doctor may request regular blood tests to monitor your blood cells and serum methotrexate concentration in the blood.

Before taking it, tell your doctor if have seizures, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using, especially phenytoin for your seizures.

Uses of Unifolin Tablet

Benefits of Unifolin Tablet

Prevention of Harmful effects of methotrexate
Unifolin 15mg Tablet helps protect the body cells against the harmful effects of methotrexate, an anti-cancer medicine. It is a form of vitamin B that is given after 24 hours of methotrexate administration. This makes sure that methotrexate has achieved its anti-cancer effects and also, Unifolin 15mg Tablet will prevent the other side effects such as anemia.

Side effects of Unifolin Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Unifolin

Limited data available

How to use Unifolin Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Unifolin 15mg Tablet may be taken with or without food.

How Unifolin Tablet works

Unifolin 15mg Tablet is a form of folinic acid that helps protect healthy cells from the toxic effects of methotrexate, a chemotherapy drug. Methotrexate works by blocking folic acid, which is needed for cell growth. Unifolin 15mg Tablet bypasses this block by supplying a usable form of folate directly to the body. This helps rescue normal cells without reducing methotrexate’s effect on cancer cells.

All substitutes for Unifolin 15mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Leucorin Tablet

by Samarth Life Sciences Pvt Ltd

₹51.1/tablet

19% costlier

Neurovorin 15 Tablet

by Vefa Lifesciences Pvt Ltd

₹44.9/tablet

5% costlier

Quick tips

You have been prescribed Unifolin 15mg Tablet to reduce the side effects of the medicine methotrexate.
Take it 24 hours after taking methotrexate. If taken at the same time, it may counteract the effect of methotrexate.
Inform your doctor if you are also taking certain medications such as phenytoin for your seizures as Unifolin 15mg Tablet may counteract the antiepileptic effects.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Unifolin 15mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Unifolin 15mg Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Unifolin 15mg Tablet during breastfeeding is not available. Please consult your doctor.

Driving

SAFE

Unifolin 15mg Tablet does not usually affect your ability to drive.

Kidney

CAUTION

Unifolin 15mg Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Unifolin 15mg Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Unifolin with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Capecitabine (Oral Route)

If concurrent use is essential, your doctor may closely monitor treatment outcomes and may modify treatment if required.

Frequently asked questions

What is Unifolin 15mg Tablet used for?

Unifolin 15mg Tablet is used to prevent harmful effects of methotrexate (a cancer chemotherapy medication) when methotrexate is used to treat certain types of cancer. Unifolin 15mg Tablet is also used to treat people who have accidentally received an overdose of methotrexate or similar medications. It is also used for the treatment of megaloblastic anemia due to folic acid deficiency and when oral therapy is not feasible.

What is megaloblastic anemia?

Anemia is a blood disorder in which the number of red blood cells (RBCs) that carry oxygen is lower than usual. As a result, your tissues and organs don’t get enough oxygen. Megaloblastic anemia is a form of anemia characterized by very large red blood cells and a decrease in the number of those cells. Usually, megaloblastic anemia is due to vitamin B12 or folic acid deficiency.

How long does it take for Unifolin 15mg Tablet to work?

Unifolin 15mg Tablet starts acting on the body within 20-30 minutes of oral intake. However, this might vary with respect to dosage, the patient receiving the drug, and response to treatment.

What are some of the laboratory tests conducted before or during the treatment with Unifolin 15mg Tablet?

Your doctor will prescribe blood tests to check your levels of serum methotrexate concentration (in case of methotrexate chemotherapy or overdose) to determine the optimal dose and duration of treatment with Unifolin 15mg Tablet. You will also be prescribed a complete blood count to monitor the number of red blood cells (in case of megaloblastic anemia). Along with this, your calcium levels will also be monitored in order to prevent hypercalcemia (excess calcium) since Unifolin 15mg Tablet contains calcium.

Fact Box

Chemical Class

Folic acid derivative

Habit Forming

Therapeutic Class

BLOOD RELATED

Action Class

Folic Acid Analogs

References

User feedback

Patients taking Unifolin 15mg Tablet

Once A Week

84%

Four Times A Day

11%

Once A Day

What are you using Unifolin Tablet for?

Ovarian cancer

100%

How much was the improvement?

Poor

50%

Average

50%

What were the side-effects while using Unifolin 15mg Tablet?

No Side Effect

100%

How do you take Unifolin Tablet?

With or without food

100%

Please rate Unifolin 15mg Tablet on price

Not Expensive

67%

Average

33%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: United Biotech Pvt Ltd
Address: FC/B-1 (Extn.), Mohan Co-operative Industrial Estate Mathura Road, New Delhi - 110 044

Vendor Details

Country of origin: India

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Blood Related

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Unifolin 15mg Tablet

Unifolin 15mg Tablet

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General Information

Contains

Salt Synonyms

Marketer

Storage

Product introduction

Uses of Unifolin Tablet

Benefits of Unifolin Tablet

Side effects of Unifolin Tablet

How to use Unifolin Tablet

How Unifolin Tablet works

All substitutes for Unifolin 15mg Tablet

Leucorin Tablet

Neurovorin 15 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Capecitabine (Oral Route)

Frequently asked questions

What is Unifolin 15mg Tablet used for?

What is megaloblastic anemia?

How long does it take for Unifolin 15mg Tablet to work?

What are some of the laboratory tests conducted before or during the treatment with Unifolin 15mg Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

Patients taking Unifolin 15mg Tablet

What are you using Unifolin Tablet for?

How much was the improvement?

What were the side-effects while using Unifolin 15mg Tablet?

How do you take Unifolin Tablet?

Please rate Unifolin 15mg Tablet on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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