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Leucorin Tablet

Calcium Leucovorin (15mg)

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Leucorin Tablet is used to prevent the harmful effects of methotrexate (anticancer medicine). It is also used in the treatment of methotrexate overdose.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 05 Jan 2026 | 05:03 PM (IST)

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General Information

Storage

Store below 30°C

The content is shown in English

Product introduction

Leucorin Tablet can be taken with or without food. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects.

It is generally safe medicine to use with no common side effects if taken in the right amount. Your doctor may request regular blood tests to monitor your blood cells and serum methotrexate concentration in the blood.

Before taking it, tell your doctor if have seizures, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using, especially phenytoin for your seizures.

Uses of Leucorin Tablet

Benefits of Leucorin Tablet

Prevention of Harmful effects of methotrexate
Leucorin Tablet helps protect the body cells against the harmful effects of methotrexate, an anti-cancer medicine. It is a form of vitamin B that is given after 24 hours of methotrexate administration. This makes sure that methotrexate has achieved its anti-cancer effects and also, Leucorin Tablet will prevent the other side effects such as anemia.

How to use Leucorin Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Leucorin Tablet may be taken with or without food.

How Leucorin Tablet works

Leucorin Tablet is a form of folinic acid that helps protect healthy cells from the toxic effects of methotrexate, a chemotherapy drug. Methotrexate works by blocking folic acid, which is needed for cell growth. Leucorin Tablet bypasses this block by supplying a usable form of folate directly to the body. This helps rescue normal cells without reducing methotrexate’s effect on cancer cells.

Quick tips

You have been prescribed Leucorin Tablet to reduce the side effects of the medicine methotrexate.
Take it 24 hours after taking methotrexate. If taken at the same time, it may counteract the effect of methotrexate.
Inform your doctor if you are also taking certain medications such as phenytoin for your seizures as Leucorin Tablet may counteract the antiepileptic effects.
You have been prescribed Leucorin Tablet to reduce the side effects of the medicine methotrexate.
Take it 24 hours after taking methotrexate. If taken at the same time, it may counteract the effect of methotrexate.
Inform your doctor if you are also taking certain medications such as phenytoin for your seizures as Leucorin Tablet may counteract the antiepileptic effects.
You have been prescribed Leucorin Tablet to reduce the side effects of the medicine methotrexate.
Take it 24 hours after taking methotrexate. If taken at the same time, it may counteract the effect of methotrexate.
Inform your doctor if you are also taking certain medications such as phenytoin for your seizures as Leucorin Tablet may counteract the antiepileptic effects.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Leucorin Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Leucorin Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Leucorin Tablet during breastfeeding is not available. Please consult your doctor.

Driving

SAFE

Leucorin Tablet does not usually affect your ability to drive.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Leucorin Tablet in patients with kidney disease. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Leucorin Tablet in patients with liver disease.

Interaction with drugs

Taking Leucorin with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Capecitabine (Oral Route)

If concurrent use is essential, your doctor may closely monitor treatment outcomes and may modify treatment if required.

Frequently asked questions

What is Leucorin Tablet used for?

Leucorin Tablet is used to prevent harmful effects of methotrexate (a cancer chemotherapy medication) when methotrexate is used to treat certain types of cancer. Leucorin Tablet is also used to treat people who have accidentally received an overdose of methotrexate or similar medications. It is also used for the treatment of megaloblastic anemia due to folic acid deficiency and when oral therapy is not feasible.

What is megaloblastic anemia?

Anemia is a blood disorder in which the number of red blood cells (RBCs) that carry oxygen is lower than usual. As a result, your tissues and organs don’t get enough oxygen. Megaloblastic anemia is a form of anemia characterized by very large red blood cells and a decrease in the number of those cells. Usually, megaloblastic anemia is due to vitamin B12 or folic acid deficiency.

How long does it take for Leucorin Tablet to work?

Leucorin Tablet starts acting on the body within 20-30 minutes of oral intake. However, this might vary with respect to dosage, the patient receiving the drug, and response to treatment.

What are some of the laboratory tests conducted before or during the treatment with Leucorin Tablet?

Your doctor will prescribe blood tests to check your levels of serum methotrexate concentration (in case of methotrexate chemotherapy or overdose) to determine the optimal dose and duration of treatment with Leucorin Tablet. You will also be prescribed a complete blood count to monitor the number of red blood cells (in case of megaloblastic anemia). Along with this, your calcium levels will also be monitored in order to prevent hypercalcemia (excess calcium) since Leucorin Tablet contains calcium.

What measures should be taken to ensure the prompt excretion of methotrexate during treatment with Leucorin Tablet?

Maintenance of urine output above 2,500 mL/24hr in adults by increasing oral or intravenous fluids 12 hours before and for 36 hours after the end of methotrexate infusion. To monitor alkalinization of urine (this enhances drug excretion) so that the urinary pH is greater than 7.0 before methotrexate infusion. Foods, drinks, and drugs that may increase urinary acidity should be avoided during the therapy. Finally, blood methotrexate concentration should be measured at least 24, 48, and 72 hours after the initiation of the methotrexate infusion.

Fact Box

Chemical Class

Folic acid derivative

Habit Forming

Therapeutic Class

BLOOD RELATED

Action Class

Folic Acid Analogs

References

User feedback

Patients taking Leucorin Tablet

Once A Day

49%

Once A Week

37%

Twice A Day

Alternate Day

Thrice A Day

Thrice A week

Twice A Week

What are you using Leucorin Tablet for?

Others

100%

How much was the improvement?

Excellent

83%

Average

17%

How do you take Leucorin Tablet?

With food

100%

Please rate Leucorin Tablet on price

Expensive

67%

Average

33%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Samarth Life Sciences Pvt Ltd
Address: 136, New Ashirwad Ind. Est. No.5, Ram Mandir Road, Goregaon (W), Mumbai - 400 104, India || Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Leucorin Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Leucorin Tablet

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General Information

Contains

Salt Synonyms

Marketer

Storage

Product introduction

Uses of Leucorin Tablet

Benefits of Leucorin Tablet

How to use Leucorin Tablet

How Leucorin Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Capecitabine (Oral Route)

Frequently asked questions

What is Leucorin Tablet used for?

What is megaloblastic anemia?

How long does it take for Leucorin Tablet to work?

What are some of the laboratory tests conducted before or during the treatment with Leucorin Tablet?

What measures should be taken to ensure the prompt excretion of methotrexate during treatment with Leucorin Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

Patients taking Leucorin Tablet

What are you using Leucorin Tablet for?

How much was the improvement?

How do you take Leucorin Tablet?

Please rate Leucorin Tablet on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

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