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MD (Pharmacology), MBBS
Last updated:
07 Aug 2020 | 10:37 AM (IST)
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Trixide-H 25mg/10mg Tablet

Prescription Required
Manufacturer
Storage
Store at room temperature (10-30°C)

Introduction

Trixide-H 25mg/10mg Tablet is a combination of two medicines. It is used in the treatment of depression associated with anxiety. It helps in regulating mood and to reduce anxiety.

Trixide-H 25mg/10mg Tablet is taken with or without food. However, it is advised to take it at a fixed time each day to maintain a consistent level of medicine in the blood. In case you miss a dose of this medicine, take it as soon as you remember. Never skip any dose and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to the doctor as it may worsen your symptoms. Taking this medicine for a long time may require regular monitoring of blood and liver functions.

Some common side effects of this medicine include constipation, difficulty in urination, weight gain, confusion, orthostatic hypotension (sudden lowering of blood pressure on standing). This medicine may cause weight loss. In case of losing weight, consult a dietitian for dietary supplements or try to increase your food portion. Most of the common side effects tend to be mild. Your doctor may be able to suggest ways of preventing or reducing side effects if they bother you or do not go away. Serious side effects are rare. Remember to inform your doctor if you develop any unusual changes in mood as it may lead to suicidal thoughts.

Take caution while taking medicine if you are suffering from liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Uses of Trixide-H Tablet

Benefits of Trixide-H Tablet

In Depression

Trixide-H 25mg/10mg Tablet works by affecting the balance of certain chemicals (such as serotonin) in the brain. It helps improve mood and feelings of wellbeing, relieve anxiety and tension, helps you sleep better, and increase your energy level. It is an effective antidepressant but may cause drowsiness. You need to take it regularly as it is prescribed for it to be most effective and should not stop taking it suddenly.

Side effects of Trixide-H Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Trixide-H

  • Constipation
  • Difficulty in urination
  • Weight gain
  • Confusion
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Tiredness
  • Blurred vision
  • Dryness in mouth
  • Increased heart rate
  • Uncoordinated body movements
  • Depression
  • Memory impairment

How to use Trixide-H Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Trixide-H 25mg/10mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Trixide-H Tablet works

Trixide-H 25mg/10mg Tablet is a combination of two medicines: Amitriptyline and Chlordiazepoxide, which treats depression. Amitriptyline is a tricyclic antidepressant which increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression. Chlordiazepoxide is a benzodiazepine (BZD) which works by increasing the action of GABA, a chemical messenger which suppresses the abnormal and excessive activity of the nerve cells in the brain.

Safety Advice

Alcohol
UNSAFE
It is unsafe to consume alcohol with Trixide-H 25mg/10mg Tablet.
Pregnancy
CONSULT YOUR DOCTOR
Trixide-H 25mg/10mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breastfeeding
CONSULT YOUR DOCTOR
Trixide-H 25mg/10mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Trixide-H 25mg/10mg Tablet may cause side effects which could affect your ability to drive.
As Trixide-H 25mg/10mg Tablet may make you feel drowsy or affect your concentration and this may affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Trixide-H 25mg/10mg Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Trixide-H 25mg/10mg Tablet may not be needed in these patients. Please consult your doctor.
Liver
CAUTION
Trixide-H 25mg/10mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Trixide-H 25mg/10mg Tablet may be needed. Please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Trixide-H 25mg/10mg Tablet
₹2.66/Tablet
Mytrip Plus Tablet
Mayflower India
₹3.1/Tablet
17% costlier
Relidep Plus 25 mg/10 mg Tablet
Reliance Formulation Pvt Ltd
₹4.1/Tablet
54% costlier
Aculip 25 mg/10 mg Tablet
Shine Pharmaceuticals Ltd
₹4.36/Tablet
64% costlier
Amixide 10mg Tablet
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₹5.3/Tablet
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₹5.72/Tablet
115% costlier

Fact Box

Habit Forming
Yes
Therapeutic Class
ANTI MALARIALS

Patient Concerns

arrow
What would be alternative for this medicine for same salt composition of some lower price. Name of the medicine -- ( Telmisartan 40 mg and Hydrochlorothiazide 12.5 mg tablets USP
Dr. Nabajit Talukdar
Cardiology
Telma h 40/12.5
I have been advised Telma 20 for my BP range 140/90, however of late it is coming 150/110. My doctor advice Telma 40. Or should I take Cilacar 10.
Dr. Nabajit Talukdar
Cardiology
take telma h 40
arrow
Do you have any questions related to Trixide-H 25mg/10mg Tablet ?

User Feedback


FAQs

Q. What are the instructions for storage and disposal of Trixide-H 25mg/10mg Tablet?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Q. Are there any important warnings associated with use of Trixide-H 25mg/10mg Tablet?

During the first few months of treatment, Trixide-H 25mg/10mg Tablet may increase suicidal thoughts or actions in some patients. Patients having mood or behavioral disorder have a high risk of developing suicidal thoughts and actions. You should pay close attention and report your doctor of any such behavior or mood changes. Make sure that you visit the doctor for the scheduled follow-up appointments.

Q. Can I stop taking Trixide-H 25mg/10mg Tablet when my symptoms are relieved?

No, you should continue to take Trixide-H 25mg/10mg Tablet, even if you feel well. If you stop Trixide-H 25mg/10mg Tablet suddenly, serious withdrawal symptoms may occur. Consult your doctor if the symptoms are relieved, he might decrease your dose gradually.

Q. How to manage weight gain associated with the use of Trixide-H 25mg/10mg Tablet?

There are reports which suggest that the use of Trixide-H 25mg/10mg Tablet can cause weight gain. If you maintain good eating habits and exercise regularly, you might not gain any weight. An important to remember is that it is easier to prevent weight gain than losing increased weight.

Q. Can the use of Trixide-H 25mg/10mg Tablet cause sleepiness?

Yes, Trixide-H 25mg/10mg Tablet can make you feel sleepy. Avoid driving, operating machinery, working at heights or participating in potentially dangerous activities till you know how this medicine affects you.

Q. Can the use of Trixide-H 25mg/10mg Tablet affect my sexual life?

The use of Trixide-H 25mg/10mg Tablet can affect the sexual life of both men and women. Most commonly caused problems are decreased sexual desire, erectile dysfunction (inability to develop or maintain erection during the sexual activity) and inability to reach orgasm. It can also cause a decrease in satisfaction and cause discomfort while having sex. If you experience these problems, discuss with your doctor.

Q. Can I drink alcohol while taking Trixide-H 25mg/10mg Tablet?

No, do not drink alcohol while you are taking Trixide-H 25mg/10mg Tablet. Drinking alcohol can increase the severity of drowsiness or sleepiness caused by Trixide-H 25mg/10mg Tablet.

Q. Can the use of Trixide-H 25mg/10mg Tablet change the color of urine?

Yes, Trixide-H 25mg/10mg Tablet can the change the color of the urine to blue or green. This change of color is expected while using Trixide-H 25mg/10mg Tablet, and it is not harmful. Your urine color becomes normal once you stop taking Trixide-H 25mg/10mg Tablet.

Q. How long does Trixide-H 25mg/10mg Tablet take to work?

Everybody responds differently to the treatment. In general, it can take several weeks to feel the full benefits of Trixide-H 25mg/10mg Tablet, although some people will start to feel better sooner. When taking Trixide-H 25mg/10mg Tablet, it is important to give it time to work.

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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. DailyMed. Chlordiazepoxide and amitriptyline hydrochloride. [Accessed 10 Apr. 2019] (online) Available from:External Link
  2. Amitriptyline. North Harrow, Middlesex: Accord Healthcare Limited; 2018. [Accessed 10 Apr. 2019] (online) Available from:External Link
  3. MedlinePlus. Chlordiazepoxide. [Accessed 10 Apr. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

1601, Karnavati Estate, GIDC, Phase III, Vatva, Ahmedabad 382445, Gujarat, India.
Country of Origin: India
NOT FOR SALE
We do not facilitate sale of this product at present

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