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Treoall Injection

Treosulfan (5gm)
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Treoall Injection is used in the treatment of blood cancer. It is used in combination with another cancer medicine called fludarabine in adults and children as young as one month of age with blood cancers as well as in adults requiring a bone marrow transplant.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 23 Mar 2026 | 11:29 AM (IST)
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Gurgaon
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Treoall Injection image
Treoall Injection image

Product introduction

Treoall Injection is given as an injection into veins by the healthcare provider. This will depend on what you are being treated for and may change from time to time. It may take several weeks or months for you to see or feel the benefits. The dose and duration of treatment will be decided by your doctor.

The most common side effects of this medicine include infections, weakness, bleeding, difficulty in breathing, nausea, hair loss, and discoloration of the skin. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them.

Inform your doctor if you have a medical history of bleeding disorders, heart or liver disease, radiation treatment or any infection. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using.  Inform your doctor immediately if you notice unusual bruising or bleeding or if you have dark, tarry, or bloody stools and sore throat.

This medicine is known to reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Treoall Injection

Benefits of Treoall Injection

Blood cancer
Blood cancers, such as leukemia, affect the production and function of blood cells, leading to symptoms like weakness, infections, and bleeding. Treoall Injection is used in these conditions as part of treatment to destroy harmful cancer cells and prepare the body for procedures like stem cell transplantation. This helps control the disease, supports healthy blood cell formation, and improves treatment outcomes.

Side effects of Treoall Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Treoall
  • Infection
  • Weakness
  • Bleeding
  • Breathing problems
  • Nausea
  • Hair loss
  • Skin discoloration

How to use Treoall Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Treoall Injection works

Treoall Injection is an alkylating agent. It works by forming cross-links between DNA strands preventing cell replication and leading to the death of the cell.

All substitutes for Treoall Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

  • Inform your doctor if you develop shortness of breath during the treatment with Treoall Injection.
  • Use contraceptives, and do not conceive a child (get pregnant) while taking this medicine. Barrier methods of contraception, such as condoms, should be used during therapy and six months after treatment.
  • You may be at risk of infection, so try to avoid crowds or people with colds, and immediately report fever or any other signs of infection to your health care provider.
  • Avoid activities that may cause injury and bleeding during your treatment.
  • Do not receive any kind of immunization or vaccination (especially live vaccines) without your doctor’s approval while taking Treoall Injection.
  • To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals.
  • Drink more fluids than usual for up to 24 hours after your treatment unless instructed otherwise.
  • Swelling of the gums may occur as a side effect. Frequent mouth rinses, good oral hygiene, and the application of ice may give relief.
  • Inform your doctor if you develop shortness of breath during the treatment with Treoall Injection.
  • Use contraceptives, and do not conceive a child (get pregnant) while taking this medicine. Barrier methods of contraception, such as condoms, should be used during therapy and six months after treatment.
  • You may be at risk of infection, so try to avoid crowds or people with colds, and immediately report fever or any other signs of infection to your health care provider.
  • Avoid activities that may cause injury and bleeding during your treatment.
  • Do not receive any kind of immunization or vaccination (especially live vaccines) without your doctor’s approval while taking Treoall Injection.
  • To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals.
  • Drink more fluids than usual for up to 24 hours after your treatment unless instructed otherwise.
  • Swelling of the gums may occur as a side effect. Frequent mouth rinses, good oral hygiene, and the application of ice may give relief.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Treoall Injection. Please consult your doctor.
Pregnancy

Pregnancy

UNSAFE
Treoall Injection is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Treoall Injection during breastfeeding is not available. Please consult your doctor.
Driving

Driving

UNSAFE
Treoall Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Do not drive if you experience nausea or vomiting.
Kidney

Kidney

UNSAFE
Treoall Injection is unsafe to use in patients with kidney disease and should be avoided.
Liver

Liver

UNSAFE
Treoall Injection is unsafe to use in patients with liver disease and should be avoided.

Interaction with drugs

Taking Treoall with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Cholera Vaccine (Inactivated) (Oral Route)

Treosulfan may reduce efficacy of Cholera Vaccine (Inactivated). Treosulfan may reduce efficacy of Cholera Vaccine (Inactivated).
Severe

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Treosulfan may reduce efficacy of Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted). Treosulfan may reduce efficacy of Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted).
Severe

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Treosulfan may reduce efficacy of Purified Vi Polysaccharide Typhoid Vaccine. Treosulfan may reduce efficacy of Purified Vi Polysaccharide Typhoid Vaccine.
Moderate

Clozapine (Oral Route)

Do not consume Clozapine with Treosulfan. If concurrent use is essential, your doctor may monitor your blood cell count frequently.
Moderate

Filgrastim (Injection Route)

Do not consume Filgrastim from 24 hours before and until 24 hours after taking Treosulfan.

Frequently asked questions

You can continue with your normal diet unless your doctor tells you otherwise. However, it is advisable to sip water regularly to prevent dehydration, eat small, simple but nourishing snacks every few hours rather than large meals, and suck on hard candy or popsicles to prevent nausea and vomiting.
You may experience bleeding from gums due to a drop in the number of platelets (blood cells) in your blood. These blood cells help the blood clot when we bruise ourselves.
Various things can help you reduce tiredness and cope with it, for example, gentle exercise. However, always consult your doctor before doing any kind of exercise.
Yes, while taking this medicine, your hair may become brittle and break. You may also experience patchy hair loss or thinning. These conditions tend to resolve once the treatment is stopped. Be gentle when brushing and washing hair to manage hair loss.
Use a moisturizer to get relief from rashes, and dry and itchy skin. Avoid direct sunlight, wear protective clothing, and use sunscreen (SPF of more than 15) whenever you step outdoors. Do not go swimming if you have a rash because the chlorine in the water can worsen it. Avoid hot water baths and wear loose and cotton fabric clothes. Your skin will tend to become better once the treatment is stopped.
During your treatment, it is advisable to avoid caffeine as it can make you feel dehydrated, avoid fatty fried, spicy, and overly sweet foods, as they may induce nausea, and avoid alcohol and smoking. It is also advisable to avoid crowds or people with colds, as you may be at risk of infection as well as sun exposure to prevent rashes and dry skin. Use caution with sharp objects like razors or nail cutters and avoid activities such as contact sports to lower the chance of getting cut, bruised, or injured.
This treatment may harm a baby developing in the womb. Therefore, it is important not to conceive or father a child while you are on a treatment with Treoall Injection and for at least 6 months after stopping the treatment. Talk to your doctor about effective contraception before starting the treatment.
Your doctor will prescribe blood tests to check your levels of blood cells and how well your liver and kidneys are working.

Fact Box

Chemical Class

Organosulfonic acid esters

Habit Forming

No

Action Class

Alkylating Agents
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Hetero Healthcare Limited
Address: S.no: 80-84, Melange towers, PatrikaNagar,Madhapur,Hyderabad. Telangana-500081.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Treoall Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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