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Composition for TOLREST

Tolperisone(450 mg)

food interaction for TOLREST

alcohol interaction for TOLREST

pregnancy interaction for TOLREST

lactation interaction for TOLREST

It is better to take Tolrest 450 mg tablet with food.
Interaction with alcohol is unknown. Please consult your doctor.
Tolrest 450 mg tablet may be unsafe to use during pregnancy.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Tolperisone(450 mg)


Tolrest 450 mg tablet is used to relieve stiffness or rigidity of muscles (muscle spasticity) and muscular contraction (spasm). It is used in the treatment of unusual stiffness of muscle after certain neurological diseases in adults.

How it works

Tolrest 450 mg tablet belongs to group of medicines called muscle relaxant. It works by action on central nervous system. It has pain relieving (analgesic) activity too.

Common side effects

Pale red skin, Itchy rash, Rash, Decreased blood pressure, Shortness of breath, Eye swelling, Lip swelling, Itching, Severe systemic reactions, Skin redness, Tachycardia


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Expert advice for TOLREST

  • Tolperisone tablet should be taken after meals with a glass of water.
  • Do not drive because you may feel sleepy or dizzy while being treated with tolperisone.
  • Women and patients with hypersensitivity to other drugs (e.g., lidocaine) or with a history of allergy may be at a higher risk of hypersensitivity to tolperisone.
Do not start or continue the tolperisone and consult your doctor:
  • If you experience disturbance in attention, fits (epilepsy), blurred vision or muscular weakness.
  • If you experience viral infections at the same time.
  • If you have a history of allergic diseases such as runny nose due to allergy (hay fever), asthma, eczema (atopic dermatitis) with high serum IgE, and pale red, raised, itchy skin rash (urticaria).
  • If you are pregnant or planning to become pregnant or breastfeeding.

Frequently asked questions for TOLREST


Q. Is tolperisone a steroid, stimulant, or addictive drug?
No, tolperisone is not a steroid, stimulant or addictive drug. It is a muscle relaxant.
Q. Is tolperisone or Synaptol safe?
Tolperisone or Synaptol (brand name of tolperisone) is safe if used at prescribed doses for the prescribed duration as advised by your doctor.
Q. Can I take Synaptol with concerta?
 The use of Synaptol with concerta (methylphenidate) should be avoided.

Q. Does Synaptol work for Attention Deficit Disorder (ADD) or Attention Deficit Hyperactivity Disorder (ADHD)?
Use of Synaptol or tolperisone is not approved for Attention Deficit Disorder (ADD) or Attention Deficit Hyperactivity Disorder (ADHD).
Q. Does Synaptol work for adults?
Yes Synaptol is used in the treatment of unusual tightness of muscle after a stroke in adults.
Q. Does Synaptol cause weight loss or weight gain, or suppress appetite?
There is no data about Synaptol causing weight loss or weight gain, or suppress appetite. Please consult your doctor before taking the drug.


Content on this page was last updated on 13 December, 2015, by Dr. Varun Gupta (MD Pharmacology)