Tishtha 40 Injection

Nivolumab (10mg/ml)

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Prescription

required

Cold stored

Stored between 2-8°C

Tishtha 40 Injection is used in the treatment of non-small cell lung cancer, kidney cancer, head and neck cancer, melanoma, Hodgkin's disease, and liver cancer.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 19 Jul 2026 | 01:02 AM (IST)

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General Information

Contains

Nivolumab (10mg/ml)

Marketer

Zydus Lifesciences Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Tishtha 40 Injection is given as an infusion into vein by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Some common side effects of this medicine include rash, weakness, headache, and fever. Some serious side effects which may occur during infusion include chills or shaking, itching, rash, flushing, difficulty breathing and dizziness. Hence, your doctor will check you timely after infusion for allergic reaction.

Before taking it, tell your doctor if have lung disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. Use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Tishtha Injection

Benefits of Tishtha Injection

Head and neck cancer
Head and neck cancer includes cancer of the mouth, nose, sinuses or throat. Tishtha 40 Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol or smoking while having this treatment and drink plenty of water to stay hydrated.

Kidney cancer
Tishtha 40 Injection is used to treat kidney cancer and its associated symptoms such as blood in the urine, unexplained low back pain or weight loss, fatigue, loss of appetite, etc. It stops cancer growth and prevents multiplication of cancer cells. This restricts the advancement of cancer to other unaffected regions. You need to follow your doctor’s instructions very carefully to recover.

Hodgkin’s disease
Hodgkin’s disease is a type of lymphoma, which is a blood cancer that starts in the lymphatic system. The lymphatic system helps the immune system get rid of waste and fight infections. Tishtha 40 Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. Follow your doctor’s instructions carefully.

Non-small cell lung cancer
Non-small cell lung cancer is one of the major kinds of lung cancer and it affects both smokers as well as non-smokers. Tishtha 40 Injection helps treat non-small cell lung cancer and may be given alone or in combination with other medicines. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Liver cancer
Liver cancer is the cancer that develops in the cells of the liver called hepatocytes. There may be no symptoms present in the early stages of the cancer but as the disease advances to later stages symptoms such as weight loss, stomach pain, vomiting and yellowed skin. Tishtha 40 Injection kills the cancer cells and prevents further growth and spread of cancer to other unaffected areas. Follow your doctor’s instructions carefully and do not drink alcohol or smoke. Alcohol intake or smoking can worsen your condition and hinder your recovery.

Melanoma
Melanoma is a type of skin cancer that develops in melanocytes, the cells that produce the pigment called melanin. Melanin is the pigment that gives the skin its color. Melanoma is the most deadly and aggressive kind of skin cancer. Tishtha 40 Injection sticks to the genetic code, called DNA,of the cancer cells and kills them . It also prevents their growth and further spread. This helps to treat the cancer.

Side effects of Tishtha Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Tishtha

Rash
Weakness
Headache
Fever
Musculoskeletal (bone, muscle or joint) pain
Back pain
Stomach pain
Nausea
Itching
Constipation
Diarrhea
Upper respiratory tract infection
Decreased appetite
Breathlessness
Cough

How to use Tishtha Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Tishtha Injection works

Tishtha 40 Injection is an anti-cancer medication. It works by blocking a protein (PD-1) on the surface of certain immune cells called T-cells. This action activates the T-cells to locate and kill cancer cells.

Quick tips

Tishtha 40 Injection is given as in injection or infusion under the supervision of a doctor only.
Do not skip any dose and complete the course as suggested by your doctor.
Use an effective method of birth control to avoid pregnancy while taking this medication.
Your doctor may get regular blood tests done to monitor your blood cell count (CBC), electrolyte levels, liver and kidney function.
Inform your doctor if you experience fever, chills, rash and shortness of breath during the treatment.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Tishtha 40 Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Tishtha 40 Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Tishtha 40 Injection during breastfeeding is not available. Please consult your doctor.

Driving

SAFE

Tishtha 40 Injection does not usually affect your ability to drive.

Kidney

CAUTION

Tishtha 40 Injection should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Tishtha 40 Injection should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Tishtha with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Do not use Nivolumab with Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted).

Severe

Cholera Vaccine (Inactivated) (Oral Route)

Do not use Nivolumab with Cholera Vaccine (Inactivated).

Severe

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Do not use Nivolumab with Purified Vi Polysaccharide Typhoid Vaccine.

Moderate

Betamethasone (Oral Route)

Do not consume Nivolumab with Betamethasone. If concurrent use is essential, please consult your doctor.

Moderate

Betamethasone (Injection Route)

Do not consume Nivolumab with Betamethasone. If concurrent use is essential, please consult your doctor.

Fact Box

Chemical Class

Peptides

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

PD-1 (Programmed Cell Death Protein 1) Inhibitors

Related lab tests

Alpha-fetoprotein (AFP) L3 Fraction

Complete Blood Count

References

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Zydus Lifesciences Ltd
Address: Plot Survey No. 23, 25/P, 37, 40/P, 42 to 47, Sarkhej–Bavla N.H. No. 8A, Opp. Ramdev Masala, Village: Changodar, Taluka: Sanand, Dist. Ahmedabad – 382213, Gujarat, India.

Vendor Details

Country of origin: India

Lab tests offered by us

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Tishtha 40 Injection

Tishtha 40 Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Tishtha Injection

Benefits of Tishtha Injection

Side effects of Tishtha Injection

How to use Tishtha Injection

How Tishtha Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Cholera Vaccine (Inactivated) (Oral Route)

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Betamethasone (Oral Route)

Betamethasone (Injection Route)

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Alpha-fetoprotein (AFP) L3 Fraction

Complete Blood Count

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests