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Temotide 250mg Tablet

Written By Dr. Syeda Aafia, MBA, BDS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 14 Apr 2026 | 04:21 PM (IST)
Temotide 250mg Tablet is used in the treatment of a specific type of cancer of the brain. It is used to treat brain tumors if they return or get worse after standard treatment. It may be also used to treat other conditions, as determined by the doctor.
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General Information

The content is shown in English
Temotide 250mg Tablet image
Temotide 250mg Tablet image

Product introduction

Temotide 250mg Tablet should be taken empty stomach and at same time each day to make sure it has the best effect. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include nausea, vomiting, constipation, headache and fatigue. This medicine may reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine.

Before taking it, tell your doctor if have bleeding, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. You and your partner should avoid becoming pregnant or fathering a child for several months after your treatment with it has stopped.

Uses of Temotide Tablet

Benefits of Temotide Tablet

Brain tumor
Brain tumor is an abnormal mass or collection of cells that may be cancerous (malignant) or non-cancerous (benign). Temotide 250mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Side effects of Temotide Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Temotide
  • Nausea
  • Vomiting
  • Constipation
  • Headache
  • Fatigue
  • Convulsion
  • Coordination disorder
  • Diarrhea
  • Dizziness
  • Fever
  • Hair loss
  • Hemiparesis (weakness on one side of the body)
  • Insomnia (difficulty in sleeping)
  • Loss of appetite
  • Memory loss
  • Rash
  • Viral infection
  • Weakness

How to use Temotide Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Temotide 250mg Tablet is to be taken on an empty stomach.

How Temotide Tablet works

Temotide 250mg Tablet is an anti-cancer medication. It enters the brain tissues and works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

All substitutes for Temotide 250mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

  • Temotide 250mg Tablet should be taken on an empty stomach.
  • Do not skip any dose and complete the course as suggested by your doctor.
  • Use an effective method of birth control to avoid pregnancy while taking this medication.
  • It increases your risk of bleeding. Be careful while shaving, cutting fingernails or toenails, or using sharp objects.
  • Your doctor may get regular blood tests done to monitor your blood cell count and liver function.
  • Inform your doctor if you experience severe skin rash, fever, chills, headache and shortness of breath during the treatment.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Temotide 250mg Tablet. Please consult your doctor.
Pregnancy

Pregnancy

UNSAFE
Temotide 250mg Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

UNSAFE
Temotide 250mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving

Driving

UNSAFE
Temotide 250mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Temotide 250mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Cautious use is advised in patients with severe kidney disease while they are taking Temotide 250mg Tablet.
Liver

Liver

CAUTION
Temotide 250mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment may be needed.
Limited information is available on the use of Temotide 250mg Tablet in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.

Interaction with drugs

Taking Temotide with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Natalizumab (Injection Route)

Do not consume Natalizumab with Temozolomide.
Severe

Cholera Vaccine (Inactivated) (Oral Route)

Temozolomide may reduce efficacy of Cholera Vaccine (Inactivated). Temozolomide may reduce efficacy of Cholera Vaccine (Inactivated).
Severe

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Temozolomide may reduce efficacy of Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted). Temozolomide may reduce efficacy of Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted).
Severe

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Temozolomide may reduce efficacy of Purified Vi Polysaccharide Typhoid Vaccine. Temozolomide may reduce efficacy of Purified Vi Polysaccharide Typhoid Vaccine.
Severe

Filgrastim (Injection Route)

Temozolomide may reduce the efficacy of Filgrastim. Temozolomide may reduce the efficacy of Filgrastim.

Frequently asked questions

Temotide 250mg Tablet is used to treat certain types of brain cancer, including glioblastoma multiforme and anaplastic astrocytoma. It works by slowing or stopping the growth of cancer cells.
Yes. Serious side effects of Temotide 250mg Tablet include low blood cell counts (increasing infection or bleeding risk), liver problems, severe allergic reactions, and leukemia. Your doctor may advise routine blood tests to monitor for these issues.
The treatment length of Temotide 250mg Tablet depends on your type of brain cancer and response to this medicine. Your doctor may prescribe it in cycles, including a 5-day schedule every 28 days. Stick to the prescribed treatment regimen for safer and faster results.
It is best to take Temotide 250mg Tablet on an empty stomach. Taking it with food may reduce how well your body absorbs the medicine.
While using Temotide 250mg Tablet, you should wash your hands after handling this medicine, avoid contact with sick people (due to low immunity), use effective birth control as the drug may harm an unborn baby, and do not break this medicine.
Individuals should not take Temotide 250mg Tablet if they are allergic to temozolomide or any other ingredients present in Temotide 250mg Tablet, have severely low blood cell counts, or are pregnant or planning pregnancy.

Fact Box

Chemical Class

Imidazotetrazines

Habit Forming

No

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Alkylating Agents

References

  1. Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1687.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1324-25.
  3. Temozolomide. Whitehouse Station, New Jersey: Merck & Co., Inc.; 1999 [revised Sep. 2015]. [Accecssed 25 Jan. 2019] (online) Available from:
  4. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Temozolamide. [Updated 2018 Dec 3]. [Accessed 18 Feb. 2020] (online) Available from:
  5. Temozolomide. Bridgewater, NJ: Amneal Pharmaceuticals of New York, LLC; 2024 [Accessed 08 Nov. 2025] (online). Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: RPG Life Sciences Ltd
Address: 463, 4 th Floor, RPG HOUSE, Dr. Annie Besant Road, Worli, Mumbai – 400 030. Maharashtra, INDIA

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Temotide 250mg Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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