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MRP: Rs. 496.20 for 1 vial(s) (1 injection each)
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Composition for TAVERA

Piperacillin(4000 mg),Tazobactum(500 mg)

food interaction for TAVERA

alcohol interaction for TAVERA

pregnancy interaction for TAVERA

lactation interaction for TAVERA

There is no data available. Please consult doctor before consuming the drug.
Interaction with alcohol is unknown. Please consult your doctor.
Tavera 4000mg/500mg injection is probably safe to use during pregnancy.
Either animal studies have shown no adverse effect on the fetus, but there is no human studies or animal studies have shown an adverse effect that was not confirmed in human studies. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Piperacillin(4000 mg)


Piperacillin, in combination with a beta lactamase inhibitor (tazobactam) is used to treat pneumonia, complicated intra-abdominal infections urinary tract and kidney infections, skin or soft tissue infections, burns or ulcers due to diabetes (diabetic foot and  serious infections of pelvic and respiratory tract  It is also used to treat decrease in white blood cells (neutropenia) with fever due to bacterial infection and hospital acquired infections.

How it works

Piperacillin belongs to a group of medicines called beta-lactam antibiotic. It is a semi-synthetic, extended spectrum penicillin. It is available in fixed combinations with beta lactamase inhibitor (tazobactam) that extends its activity against resistant bacteria. It kills the bacteria by interrupting the bacterial cell wall (outer coating of bacteria) formation. As a result, the bacterial cell wall is weakened and ruptured, thereby killing the bacteria.

Common side effects

Nausea, Pain, Swelling, Inflammation of wall of vein, Inflammation of a vein, Itchy rash, Liver enzyme increased, Abnormal blood cell count, Allergic reaction, Constipation, Decreased blood pressure, Diarrhoea, Fungal infection, Headache, Increased creatinine level in blood, Indigestion, Insomnia, Itching, Jaundice, Mouth inflammation, Lip inflammation, Rash, Vomiting
Tazobactum(500 mg)


Tazobactam is an antibiotic used in  combination with another antibiotic called piperacillin to treat many infections caused by bacteria, such as urinary tract infections, bone and joint infections, severe vaginal infections, stomach infections, skin infections, and pneumonia. It is also used to treat complicated intra-abdominal infections including inflammation of the membrane which lines the inside of the abdomen and the entire internal organs It is also used to treat decrease in white blood cells (neutropenia) with fever due to bacterial infection. 

How it works

Tazobactam belongs to group of medicines called beta lactamase Inhibitor  It works by preventing destruction of beta-lactam antibiotics from chemicals released from bacteria and extends their spectrum of activity.

Common side effects

Liver enzyme increased, Bruise, Bleeding, Constipation, Diarrhoea, Altered taste, Shortness of breath, Flatulence, Headache, Insomnia, Itching, Skin rash, Stomach upset, Vomiting


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Expert advice for TAVERA

  • It is usually given by a doctor or a nurse as an injection directly into the vein or muscle.
  • Tell the doctor if you have to provide a blood or urine sample for any test because piperacillin and tazobactam may cause false positive results.
  • Do not start or continue the piperacillin/tazobactam and consult your doctor, If you have known allergy to penicillin, tazobactam or other beta-lactam antibiotics, If you are pregnant or planning to become pregnant or breastfeeding.

Frequently asked questions for TAVERA


Q. Is piperacillin related to penicillin?
Yes, piperacillin is a semi-synthetic, extended spectrum penicillin.
Q. Is piperacillin compatible with morphine?
Piperacillin is not reported to interact with morphine. Please follow the advice of the doctor regarding their simultaneous use.
Q. What is piperacillin tazobactam?
Piperacillin and tazobactam are used as combination therapy for bacterial infections. Tazobactam reduces the destruction of piperacillin from chemicals released from bacteria and extends their spectrum of activity.
Q. What organisms does piperacillin cover?
Piperacillin is mainly effective against enterococcus, listeria, and serious gram-negative infections. It does not act against methicillin-resistant staphylococci.
Q. Is piperacillin nephrotoxic?
Piperacillin may be nephrotoxic when taken along with vancomycin or when given to children with cancer or other impairments. Consult and inform your doctor about any medical problems you may have before taking piperacillin.
Q. Is piperacillin safe?
Piperacillin is relatively safe if used at prescribed doses for the prescribed duration as advised by your doctor.


Q. Is tazobactam a sulfa (sulfonamide) drug?
Sulbactam does not contain sulfa. It is a beta lactamase Inhibitor.
Q. What is tazobactam sodium?
Tazobactam is a beta-lactamase inhibitor used as the sodium salt to increase the antibacterial activity of piperacillin.
Q. What is tazact 4.5?
Tazact 4.5 is the brand name for combination of tazobactam and piperacillin.
Q. What organisms does tazobactam/piperacillin cover?
Tazobactam in combination with piperacillin is mainly effective against anaerobes and enterococcus, listeria, staphylococcus, citrobacter, haemophilus, moraxella and proteus species but methicillin-resistant staphylococci are resistant to tazobactam/piperacillin.
Q. Is tazobactam safe?
Tazobactam is safe if used at prescribed doses for the prescribed duration as advised by your doctor.


Content on this page was last updated on 09 July, 2014, by Dr. Varun Gupta (MD Pharmacology)