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Spegra Tablet is a combination of antiretrovirals medicines. It is prescribed to treat HIV (human immunodeficiency virus) infection. It boosts up the immunity to fight against HIV to manage or treat AIDS (acquired immunodeficiency syndrome).

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 23 Mar 2026 | 11:06 AM (IST)
₹12476 MRP ₹135648% off 
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General Information

Contains

Dolutegravir (50mg)+ Emtricitabine (200mg)+ Tenofovir Alafenamide (25mg)

Marketer

Emcure Pharmaceuticals Ltd

Storage

Store below 30°C
The content is shown in English
Spegra Tablet image
Spegra Tablet image
Spegra Tablet image
Spegra Tablet image

Product introduction

Spegra Tablet restricts the growth of HIV in the body and reduces the risk of getting HIV-related complications to improve the lifespan of an individual. The medicine can be taken with or without food. Taking these medicines regularly at the same time increases their effectiveness. A dose of this medicine should not be missed as it can affect your recovery. It is important to complete the full course of the treatment until your doctor advises you to stop it. Sudden discontinuation of the treatment may affect the potency of the medicine.

The most common side effects of this medicine are insomnia, fatigue, headache, nausea, adn diarrhea. These side effects are generally temporary, but if they persist or become serious inform your doctor. This medicine can also make you feel lazy or weak, so it is advised to avoid driving. Drinking plenty of fluid can help you to cope up with the side effects, so stay hydrated.

Before starting with the treatment, you should consult your doctor if you are pregnant or breastfeeding, or have any health condition. Your doctor may suggest regular blood tests to check your blood counts, kidney and liver functions, and other health conditions. If you are HIV positive, you should not breastfeed or share personal belongings like razors or toothbrushes. Consult your doctor to know about safe sex methods in order to prevent transmission of HIV during intercourse.

Uses of Spegra Tablet

Benefits of Spegra Tablet

Treatment of HIV infection
Spegra Tablet prevents HIV from multiplying in the body. It helps control the infection and make the immune system work better. This lowers the chances of getting complications, such as new infections, and improves the quality of life. This medicine is always taken in combination with other antiretroviral medicines.

It is not a cure of HIV or AIDS and should not be used to prevent HIV after accidental exposure to a risk. It is important to take this medicine as prescribed by the doctor. Taking all doses in the right amount at the right times greatly increases the effectiveness of this combination of medicines and reduces the chances of HIV infection becoming resistant to antiretroviral medicines. Although taking this medicine does not prevent the passing of HIV to other people.

Side effects of Spegra Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Spegra
  • Diarrhea
  • Headache
  • Nausea
  • Fatigue
  • Insomnia (difficulty in sleeping)

How to use Spegra Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Spegra Tablet may be taken with or without food.

How Spegra Tablet works

Spegra Tablet is a combination of three medicines: Dolutegravir, Emtricitabine and Tenofovir Alafenamide. It is an anti-HIV medication and works by preventing the action of reverse transcriptase enzyme. This enzyme is responsible for production of HIV.

Quick tips

  • Spegra Tablet is given to slow the progress of HIV infection.
  • Although treatment with Spegra Tablet can reduce the risk of you passing HIV to others through sexual contact, it does not stop it. It is therefore important to use condoms.
  • If you develop any infection soon after taking Spegra Tablet, inform your doctor. As a result of taking Spegra Tablet, your immune system may start fighting an infection that was present before you started the treatment, but you might not be aware of.
  • It may cause weakening of your bones. Exercise regularly and take calcium and vitamin D supplements as suggested by your doctor.
  • It is common for people with HIV to feel low or even depressed, especially soon after the diagnosis has been made. If you have any feelings of depression it is advisable to speak with your doctor.

Safety advice

Alcohol

Alcohol

CAUTION
Alcohol should be used with caution while taking Spegra Tablet.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Spegra Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

UNSAFE
Spegra Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Spegra Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

UNSAFE
Spegra Tablet is unsafe to use in patients with kidney disease and should be avoided.
Liver

Liver

UNSAFE
Spegra Tablet is unsafe to use in patients with liver disease and should be avoided.

Frequently asked questions

Spegra Tablet is used to treat HIV-1 infection as a complete regimen to help keep the virus under control and protect your immune system. It may be started in people with no known resistance to these medicines, as advised by your doctor.
An individual should not take Spegra Tablet if they have ever had a severe allergic reaction to dolutegravir, emtricitabine, or tenofovir alafenamide, or any ingredient of the medicine. Also, Spegra Tablet should be avoided if taking dofetilide (a heart rhythm medicine), because of dangerous interactions with dolutegravir.
Emtricitabine and tenofovir alafenamide present in Spegra Tablet also act against hepatitis B. If you have HBV and later stop this medicine suddenly, your hepatitis B can flare up and become serious. That’s why doctors test for HBV first and monitor closely if treatment stops.
Serious side effects of Spegra Tablet include severe allergic reaction (rash with fever, mouth sores, swelling, trouble breathing), severe liver problems (yellow skin/eyes, dark urine, stomach pain, extreme tiredness), and lactic acidosis symptoms (deep/fast breathing, severe fatigue, nausea, belly pain). Get medical care immediately if these occur.
Spegra Tablet may affect kidneys and bones. Your doctor may check kidney function and bone health if you are at risk. Tell your doctor if you have a history of kidney disease, bone problems, or if you take other kidney-impacting medicines.
Yes. If you also have hepatitis B, stopping Spegra Tablet can cause a serious flare of hepatitis. Even without HBV, stopping HIV medicines can let the virus rebound and risk resistance. Always talk to your doctor before stopping or changing doses.
Some people taking Spegra Tablet report sleep problems, anxiety, or low mood. Tell your doctor if you notice worsening sleep, depression, or unusual thoughts. Your doctor may review your treatment plan.
Getting HIV under control by Spegra Tablet lowers infection risk overall. However, when your immune system starts to recover, it can cause an inflammatory “immune reconstitution” response to old, hidden infections. Report new or worsening symptoms (fever, cough, eye changes, swollen glands) promptly.

Fact Box

Habit Forming

No

Therapeutic Class

ANTI INFECTIVES

Related lab tests

HIV 1 & 2, Ab Western Blot

HIV 1 And 2 Antibody - Chromatography

HIV 1 And 2 Antibody - ELISA

References

  1. Flexner CW. Antiretroviral Agents and Treatment of HIV Infection. In: Brunton LL, Hilal-Dandan R, Knollmann BC (Editors). Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 13th ed. New York, NY: McGraw-Hill Education; 2018. pp. 1138-1157.
  2. Safrin S. Antiviral Agents. In: Katzung BG, Masters SB, Trevor AJ (Editors). Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 861-890.
  3. Dolutegravir, emtricitabine and tenofovir alafenamide [FDA Label]. Hyderabad, India: Mylan Laboratories Limited; 2018. [Accessed 16 Apr. 2021] (online) Available from:
  4. Dolutegravir, emtricitabine and tenofovir alafenamide [Prescribing Information]. Anakapalli, India: Laurus Labs Limited; 2023. [Accessed 22 Aug. 2024] (online) Available from:
  5. Dolutegravir, emtricitabine and tenofovir alafenamide [Prescribing Information]. Telangana, Hyderabad: M/s. hetero labs Limited; 2025. [Accessed 23 Mar. 2026] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Emcure Pharmaceuticals Ltd
Address: 255/2, Hinjawadi, Pune - 411057, India / Godown A, Gat No. 408 and 410, Vill: Urse, Tal: Maval, Pune-410 506, Maharashtra, India.

Vendor Details

Country of origin: India

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