Overview
Uses and benefits
Side effects
How to use
How drug works
Safety advice
Missed dose
All substitutes
Quick tips
Fact box
Patient concerns
FAQs

Author Details

Written By

Dr. Mayank

Pharm.D

Reviewed By

Dr. Lalit Kanodia

MBA, MD Pharmacology

Last updated

22 Sep 2025 | 12:24 AM (IST)

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Sitazit-DM ER 500/10 Tablet

Prescription Required

Marketer

Glenmark Pharmaceuticals Ltd

SALT COMPOSITION

Dapagliflozin (10mg) + Metformin (500mg) + Sitagliptin (100mg)

Storage

Store below 30°C

View available alternative with same salt composition

Click here to view all substitutes

Product introduction

Sitazit-DM ER 500/10 Tablet is a combination medicine that helps control blood sugar levels. This medicine is used with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. It helps in the proper utilization of insulin, thereby lowering the blood sugar level.

Sitazit-DM ER 500/10 Tablet can be taken with or without food at any time of the day, but try to take it at the same time every day. The dose will be decided by your doctor, so do not stop taking it without asking them. If you do, your blood sugar levels may increase your risk of serious complications like kidney damage and blindness. This medicine is only a part of the treatment program that should include a healthy diet, regular exercise, and weight reduction as advised by your doctor.

The most common side effects of this medicine include urinary tract infection, nasal congestion, sore throat, and upper respiratory tract infection. Drinking plenty of fluids while using it will help prevent dehydration. Some people may develop fungal infections in the genital area. Maintaining good hygiene can help prevent this.

Before taking Sitazit-DM ER 500/10 Tablet, inform your doctor if you have any kidney or liver problems, a urinary tract infection, or if you are on water pills (diuretics). Pregnant or breastfeeding women should also consult their doctor before taking it. Avoid excessive alcohol intake while taking this medicine, as this may increase the risk of some side effects. Monitor your blood sugar levels regularly while taking this medicine.

Uses of Sitazit-DM Tablet ER

Treatment of Type 2 diabetes mellitus

Benefits of Sitazit-DM Tablet ER

In Treatment of Type 2 diabetes mellitus

Sitazit-DM ER 500/10 Tablet is a medicine that helps control high blood glucose (sugar) levels. It helps get rid of extra glucose from the body through urine. Lowering blood glucose levels is an essential part of managing diabetes, as this reduces the risk of serious complications, such as kidney damage, eye damage, nerve problems, and loss of limbs. This medicine will reduce the risk of death from cardiovascular disease if you have type 2 diabetes and cardiovascular disease.

Taking Sitazit-DM ER 500/10 Tablet regularly along with proper diet and exercise will help you live a normal, healthy life. You should keep using it for as long as it is prescribed for a healthy future.

Side effects of Sitazit-DM Tablet ER

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Sitazit-DM

Diarrhea
Nausea
Vomiting
Flatulence
Genital fungal infection
Nasopharyngitis (inflammation of the throat and nasal passages)
Urinary tract infection
Headache

How to use Sitazit-DM Tablet ER

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sitazit-DM ER 500/10 Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Sitazit-DM Tablet ER works

Sitazit-DM ER 500/10 Tablet is a combination of three antidiabetic medicines. Dapagliflozin increases urinary glucose excretion and reduces blood glucose levels. Metformin decreases the amount of glucose you absorb from your food and the amount of glucose made by the liver. Metformin also increases the body's response to insulin, a natural substance that controls the amount of glucose in the blood. Sitagliptin helps control blood sugar levels by increasing substances (incretins) in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Sitazit-DM ER 500/10 Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Information regarding the use of Sitazit-DM ER 500/10 Tablet during pregnancy is not available. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Sitazit-DM ER 500/10 Tablet during breastfeeding is not available. Please consult your doctor.

Driving

UNSAFE

Sitazit-DM ER 500/10 Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Sitazit-DM ER 500/10 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Sitazit-DM ER 500/10 Tablet may be needed. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited information available on the use of Sitazit-DM ER 500/10 Tablet in patients with liver disease. Please consult your doctor.

What if you forget to take Sitazit-DM Tablet ER?

If you miss a dose of Sitazit-DM ER 500/10 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Sitazit-DM ER 500/10 Tablet

₹21.1/Tablet ER

Udapa-Trio Tablet ER

USV Ltd

₹17.6/tablet er

17% cheaper

Dapanorm Trio Tablet ER

Alkem Laboratories Ltd

₹20.1/tablet er

5% cheaper

Istamet D-XR 500 Tablet

Sun Pharmaceutical Industries Ltd

₹19.14/tablet er

9% cheaper

Oxramet-S XR 500 Tablet ER

Sun Pharmaceutical Industries Ltd

₹19.14/tablet er

9% cheaper

SitaXA DM 10/100/500 Tablet ER

Torrent Pharmaceuticals Ltd

₹19.7/tablet er

7% cheaper

View all substitutes

Quick tips

Your doctor will monitor your blood sugar levels and kidney function regularly while you are taking this medication.
Hypoglycemia (low blood sugar level) may occur when Sitazit-DM ER 500/10 Tablet is taken along with other antidiabetic medicines, alcohol, or when delaying/skipping a meal. Check your blood sugar levels and have a snack/sugar source for immediate relief.
If you get unusually thirsty, pass urine more frequently, or feel tired, let your doctor know. These are signs that there is too much sugar in your blood, and your dose may need adjusting.
Lifestyle changes, like a low-fat and salt diet, exercise, not smoking, and cutting down on the amount of alcohol you normally drink, may help this medicine work better.

Fact Box

Habit Forming

Therapeutic Class

ANTI DIABETIC

Patient concerns

I have type 2 diabetes is there a cure in ayurveda

Dr. Ravi Shankar M.

Ayurveda

There is no cure for DM . DO regular exercise, proper diet and then only medicines will help. What are your readings

Which medicine is better for control diabetes?

Dr. Sanjay Bhatt

Physician

Dedends on control of DM

Sir i am type 1 dm pls wich tablet we take

Dr. Sanjay Bhatt

Physician

Type 1 has to manage with insullinA person can control his or her sugar levels by regular exercise and walk or regular aerobic exercises at least 30 to 45 minutes per day.MEDICAL NUTRITIONAL THERAPY THAT IS TO MAINTAIN CALORIES INTAKE AS PER BMI .TAKE HELP OF DIABETIC EDUCATOR. VISIT YOU DOCTOR AND FOLLOW ALL WHAT DOCTOR SUGGESTED. ALWAYS IN TIME ALL ROUTINE INVESTIGATIONS SHOULD BE DONE.you SHOULD not treat it as disease but start of a healthy life.Uncontrolled sugar levels for long time leads to lower limb weakness which is neuropathy and which is followed by foot ulcers and other complications.online prescription is not allowed without seeing pt.so contact doctor nearby for any change or dose adjustment or visit my clinic at gurgaon sector 52 RdCity snergy multi speciality clinic near SRS MARKET

Diabetes mellitus type 2 ,thirst

Dr. Sanjay Bhatt

Physician

A person can control his or her sugar levels by doing regular exercise and walk or regular aerobic exercises at least 30 to 45 minutes per day.MEDICAL NUTRITIONAL THERAPY THAT IS TO MAINTAIN CALORIES INTAKE AS PER BMI .TAKE HELP OF DIABETIC EDUCATOR. VISIT YOUR DOCTOR AND FOLLOW ALL WHAT DOCTOR SUGGESTED.IN TIME ALL ROUTINE INVESTIGATIONS SHOULD BE DONE.you should not treat it as disease but a start of a healthy life.Uncontrolled sugar levels for long time leads to lower limb weakness which is neuropathy and which is followed by foot ulcers and other complications like kidney or heart problems .online prescription is not allowed without seeing pt.so contact doctor nearby for any change or dose adjustment or visit my clinic at gurgaon sector 52 RdCity snergy multi speciality clinic near SRS MARKET

What is Sitazit-DM ER 500/10 Tablet used for?

Sitazit-DM ER 500/10 Tablet helps lower blood sugar levels in adults with type 2 diabetes. It combines three drugs that work in different ways to improve blood sugar control and may also help with weight loss and protect the heart and kidneys in some people.

Can anyone with diabetes take Sitazit-DM ER 500/10 Tablet?

No. Sitazit-DM ER 500/10 Tablet is only for adults with type 2 diabetes. It should not be used in people with type 1 diabetes, or those who have severe kidney problems, metabolic acidosis, or diabetic ketoacidosis (DKA)—a serious condition caused by very high blood sugar.

What are the serious side effects of Sitazit-DM ER 500/10 Tablet I need to watch for?

During Sitazit-DM ER 500/10 Tablet treatment, contact a doctor if serious side effects appear. These may include signs of lactic acidosis (such as weakness, breathing difficulty, or stomach pain), symptoms of ketoacidosis (like nausea, vomiting, confusion, or fruity breath), painful or persistent genital or urinary infections, signs of pancreatitis (severe stomach pain or nausea), or allergic reactions (rash, swelling, or breathing problems). These effects are rare but require prompt medical attention.

Can Sitazit-DM ER 500/10 Tablet affect my kidneys or liver?

Yes, people with kidney or liver problems need to be monitored closely or may need a different medication. Your doctor will do regular blood tests to check your kidney and liver function during Sitazit-DM ER 500/10 Tablet treatment.

Can I take Sitazit-DM ER 500/10 Tablet if I am pregnant or breastfeeding?

Sitazit-DM ER 500/10 Tablet is not recommended during pregnancy or breastfeeding. Some of the ingredients may harm the baby or affect milk production. Let your doctor know if you're planning a pregnancy.

Will Sitazit-DM ER 500/10 Tablet make my blood sugar too low?

Sitazit-DM ER 500/10 Tablet does not usually cause low blood sugar on its own, but it can happen if you take it with insulin or certain diabetes pills. Always carry something sweet (like glucose tablets or candy) in case of symptoms like shakiness, sweating, or dizziness.

What should I avoid while taking Sitazit-DM ER 500/10 Tablet?

During Sitazit-DM ER 500/10 Tablet treatment, you should avoid drinking alcohol heavily as it increases the risk of lactic acidosis. Also, be cautious with dehydration and drink enough fluids, especially in hot weather or when you're sick.

Can I take other medicines with Sitazit-DM ER 500/10 Tablet?

Some medicines, including diuretics (water pills), blood pressure drugs, and steroids, may interact with Sitazit-DM ER 500/10 Tablet. Always tell your doctor or pharmacist about all other medicines or supplements you’re using.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Dapagliflozin [Prescribing Information]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2020. [Accessed 14 Aug. 2024] (online) Available from:
Sitagliptin/metformin HCL [Prescribing Information]. Darmstadt, Germany: Merck Sharp & Dohme Corp.; 2012. [Accessed 14 Aug. 2024] (online) Available from:
Dapagliflozin+Metformin+Sitagliptin [Prescribing Information]. Telangana, India: MSN Laboratories Private Limited; 2022. [Accessed 30 Mar. 2025] (online) Available from: