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Simulect Injection

Basiliximab (20mg)

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Simulect Injection belongs to the immunosuppressant group of medicines. It regulates the immune system to prevent rejection of the kidney transplantation. It is usually prescribed in combination with some other medicines.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology,
Last updated on 01 Sep 2025 | 04:45 PM (IST)

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General Information

Contains

Basiliximab (20mg)

Marketer

Novartis India Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Simulect Injection is a prescription medicine that must be administered by a healthcare professional. You must receive the exact dose of it as per the prescription. An overdose of this medicine may have serious side effects on the body.

The common side effects of this medicine are nausea, vomiting, constipation, etc. It may also cause an injection site reaction (redness, pain, and swelling). The medicine can safely be used in children.

Before taking this medicine, it is important to consult your doctor if you have any ongoing medication for any underlying disease. Pregnant and breastfeeding women must inform the doctor prior to the initiation of this treatment. During the treatment, your doctor may advise you some laboratory tests to know the effects of the medicine in the body.

Uses of Simulect Injection

Prevention of kidney transplant rejection

Benefits of Simulect Injection

Prevention of kidney transplant rejection
Simulect Injection is used with other medications to prevent kidney transplant rejection. Rejection usually happens due to attack by the immune system of the person receiving the transplanted organ on the transplant itself, in people who are receiving kidney transplants. This medicine reduces the activity of a person's own immune system and prevents any such rejection.

Side effects of Simulect Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Simulect

Nausea
Constipation
Abdominal pain
Diarrhea
Indigestion
Vomiting
Weight gain
Headache
Pain
Swelling of hands
High blood pressure
Anemia (low number of red blood cells)
Injection site reactions (pain, swelling, redness)

How to use Simulect Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Simulect Injection works

Simulect Injection suppresses the activity of body's immune system and prevents rejection of the kidney transplantation.

Quick tips

Simulect Injection is given as an injection into the veins by a healthcare provider only.
The first dose is given 2 hours before transplantation and a second dose after 4 days of surgery.
Avoid taking any vaccination while on treatment with this medicine without doctor consultation.
Simulect Injection may increase your susceptibility to infections. Inform your doctor if you get any signs of infection during treatment.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Simulect Injection. Please consult your doctor.

Pregnancy

SAFE IF PRESCRIBED

Simulect Injection is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Breast feeding

SAFE IF PRESCRIBED

Simulect Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Driving

SAFE

Simulect Injection does not usually affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Simulect Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Simulect Injection may not be needed in these patients. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited information available on the use of Simulect Injection in patients with liver disease. Please consult your doctor.

Interaction with drugs

Taking Simulect with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Ciclosporin (Oral Route)

Caution is advised when taking Basiliximab with Ciclosporin. Your doctor may closely monitor the effects of Ciclosporin if used concurrently with Basiliximab and adjust the dose if needed. Basiliximab may raise blood levels of Ciclosporin.

Moderate

Ciclosporin (Injection Route)

Moderate

Tacrolimus (Oral Route)

If concurrent use is essential, your doctor may monitor your tacrolimus levels, potassium levels and kidney function closely. They may adjust the doses as per the observations. Basiliximab may raise blood levels of Tacrolimus.

Frequently asked questions

What is Simulect Injection used for?

Simulect Injection is a class of medications called immunosuppressants. It is used to prevent immediate transplant rejection (attack of the transplanted organ by the immune system of the person receiving the organ) in people who are receiving kidney transplants.

When you must not have Simulect Injection?

Inform your doctor if you have ever had an allergic reaction to basiliximab, the active ingredient in Simulect Injection, or to any of the other ingredients of this medicine. Also, inform if you are pregnant or breastfeeding before the start of the treatment.

How should this medicine be used?

This medicine comes as a powder to be mixed with water and injected intravenously (into a vein) by a doctor or nurse in a hospital or medical facility. It is usually given in 2 doses. The first dose is usually given 2 hours before the transplant surgery, and the second dose is usually given 4 days after the transplant surgery.

When should I call my doctor right away?

Get medical help right away if you have signs of allergic reaction such as rash, hives, itching, and blisters. Also, let your doctor know if you experience wheezing, difficulty breathing, fast heartbeat, muscle aches, swelling all over the body, fever, chills, difficult or painful urination.

Can Simulect Injection be given to a breastfeeding woman?

There are no studies available concerning the excretion of basiliximab into breast milk. However, since Simulect Injection is an immunoglobulin G (IgG1K) antibody, it may cross the human placenta and may be excreted in human milk. Women receiving Simulect Injection should not breastfeed for 4 months following the last dose.

How to relieve constipation during the treatment?

To relieve constipation, include fiber in your diet (fruits and vegetables), drink 8-10 glasses of fluids a day, and keep active. A stool softener (with a doctor's prescription) once or twice a day may prevent constipation. If you do not have a bowel movement for 2-3 days, consult your doctor.

How to get relief from diarrhea while on treatment with Simulect Injection?

Food items with soluble fiber can help relieve diarrhea as they help absorb excess fluid from the body. These food items include bananas (ripe), orange, boiled potatoes, white rice, curd, and oatmeal. Diarrhea can cause dehydration in the body, so drink 8-10 glasses of water to avoid dehydration. You can also have soups and juice frequently to hydrate yourself.

Fact Box

Chemical Class

Monoclonal antibody (mAb)

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

IL-2 Receptor anatgonist

References

Lake DF, Briggs AD, Akporiaye ET. Immunopharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 979.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 124-25.
Basiliximab. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 2018. [Accessed 28 Jan. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 06 Apr. 2019] (online) Available from:

User feedback

What are you using Simulect Injection for?

Prevention of kidney transplant rejection

100%

How much was the improvement?

Poor

50%

Excellent

33%

Average

17%

What were the side-effects while using Simulect Injection?

No Side Effect

50%

Constipation

25%

Abdominal pain

25%

How do you take Simulect Injection?

With or without food

67%

With food

33%

Please rate Simulect Injection on price

Expensive

67%

Average

33%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Novartis India Ltd
Address: Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Simulect Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Simulect Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Simulect Injection

Benefits of Simulect Injection

Side effects of Simulect Injection

How to use Simulect Injection

How Simulect Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Ciclosporin (Oral Route)

Ciclosporin (Injection Route)

Tacrolimus (Oral Route)

Frequently asked questions

What is Simulect Injection used for?

When you must not have Simulect Injection?

How should this medicine be used?

When should I call my doctor right away?

Can Simulect Injection be given to a breastfeeding woman?

How to relieve constipation during the treatment?

How to get relief from diarrhea while on treatment with Simulect Injection?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

What are you using Simulect Injection for?

How much was the improvement?

What were the side-effects while using Simulect Injection?

How do you take Simulect Injection?

Please rate Simulect Injection on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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