Sebuxo 40mg Tablet

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Septalyst Lifesciences Pvt.Ltd.

Composition for Sebuxo 40mg Tablet

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Primarily used for

Potentiallyunsafewith
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Alcohol
110
₹11.0/Tablet
10 tablets in 1 strip
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Medicine Overview of Sebuxo Tablet

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Uses of Sebuxo Tablet

Sebuxo 40mg Tablet is used in the treatment of gout
It is a long-term treatment to lower blood uric acid levels and to prevent gout attacks.
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Side effects of Sebuxo Tablet

Common

Skin rash, Headache, Nausea, Edema, Increased liver enzymes, Diarrhoea.

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How to use Sebuxo Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. It can be taken with or without food, but it is better to take Sebuxo 40mg Tablet at a fixed time.

How Sebuxo Tablet works

Sebuxo 40mg tablet blocks the enzyme xanthine oxidase involved in the synthesis of uric acid and hence lowers the blood uric acid levels.

In Depth Information on Sebuxo Tablet

Expert advice for Sebuxo Tablet

  • Sebuxo is not a painkiller and it may take a few days to weeks before it starts working. You would need to take additional medicines to relieve your pain and inflammation during this time.
  • You may experience an increase in gouty attacks for first few weeks or months of taking Sebuxo. However, you must continue to take your medicine during these attacks.
  • Do not stop taking Sebuxo at once or without talking to your doctor as this may make your gout worse.
  • Drink lots of water or fluids while taking Sebuxo to decrease the risk of kidney stone formation.
  • Get your liver function tests done before you start taking this medicine and whenever asked by your doctor as Sebuxo can affect your liver.
  • Get your blood uric acid levels checked at regular intervals.
  • Sebuxo can make you feel drowsy. Avoid driving, use of machinery, or any activity that requires you to be alert.
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Warnings
Special precautions for Sebuxo 40mg Tablet
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Alcohol
CAUTION
Taking alcohol can increase your uric acid levels and hence aggravate gout.
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Pregnancy
WEIGH RISKS VS BENEFITS
Sebuxo 40mg Tablet may be unsafe to use during pregnancy.

Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
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Lactation
CAUTION
Sebuxo 40mg Tablet is probably usafe to use during lactation
. Limited human data suggests that the drug could represent a significant risk to the baby.
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Driving
Do not drive unless you are feeling well.

Sebuxo 40mg Tablet may cause dizziness, sleepiness, blurred vision, numbness or tingling sensation. This may affect your driving ability.
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Kidney
Sebuxo 40mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Sebuxo 40mg Tablet may be needed. Please consult your doctor.

Limited information is available regarding the use of Sebuxo 40mg Tablet in these patients.
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Liver
Sebuxo 40mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Sebuxo 40mg Tablet may be needed. Please consult your doctor.

Limited information is available regarding the use of Sebuxo 40mg Tablet in these patients.
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Missed Dosageuses

If you miss a dose of Febuxostat, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Patient Concerns

Frequently asked questions for Sebuxo 40mg Tablet

Frequently asked questions for Febuxostat

Q. Can I take Sebuxo with rosuvastatin?
Rosuvastatin can be taken with Sebuxo. Rosuvastatin is used to lower bad cholesterol and Sebuxo is used to lower uric acid levels in patients with gout. Many patients of high cholesterol levels also have high uric acid levels. There are no human studies available on this interaction. However, animal research shows that when given together, Sebuxo can increase the blood levels of Rosuvastatin causing a higher risk of its side effects like muscle pain and muscle damage. So, a dose adjustment of Rosuvastatin may be needed when given along with Sebuxo.
Sebuxo is not known to cause frequent urination. However, if you experience any such symptom while using the drug, consult your doctor.
Gout is a type of arthritis in which uric acid levels are very high in the blood and they get deposited in the joints causing swelling, redness and sudden pain in these joints. Sebuxo works by inhibiting the enzyme xanthine oxidase involved in the synthesis of uric acid and hence decreases the level of uric acid in the blood.
No, Sebuxo is not a steroid. It is a xanthine oxidase inhibitor and decreases the serum uric acid levels.
Sebuxo is not indicated for the treatment of hypertriglyceridemia. Conclusive evidence showing the drug lowering triglyceride levels is lacking.
After oral intake, the peak plasma concentration of Sebuxo is achieved between 1 to 1.5 hours. However, it may take a few days to weeks to show its effect and you can experience gout attacks during this time. Continue to take your medicine during this time as with continuous use these attacks would decrease.
Q. How is Sebuxo different from allopurinol?
Both allopurinol and Sebuxo work in a similar way by lowering uric acid levels. However, as compared to allopurinol, Sebuxo is seen to be more effective and faster in its action. Also, in patients taking allopurinol, a dose adjustment is needed if the patient has mild, moderate or severe renal failure while in the case of Sebuxo a dose adjustment may be needed only in patients with severe renal failure.
Sebuxo is not an over the counter product. It is a prescription medicine and is available as per the doctor's advice.
Studies have shown that Sebuxo is safe for long-term use. However, it should be taken only for the duration as per the doctor's advice.
Sebuxo is not indicated for the treatment of heart failure. However, high uric acid levels is a risk factor for cardiovascular diseases and the benefit of urate-lowering therapy for cardiac diseases is being explored.
Sebuxo is not indicated for the treatment of chronic kidney disease. However, it can be safely used in patients with mild to moderate renal failure for lowering uric acid levels. Safety of the drug in severe renal failure is not established.
Sebuxo is not used for the treatment of cancer. However, patients with malignant cancer when given anti-cancer drugs, experience a serious condition known as tumor lysis syndrome characterized by increased potassium, phosphate and uric acid levels in the blood due to the killing of cancer cells and this can lead to acute kidney injury, cardiac arrhythmia, and seizures. Sebuxo helps in this condition by lowering the uric acid levels and preventing further complications.
Q. Can I take Sebuxo with allopurinol?
Both Sebuxo and allopurinol are uric acid lowering agents and work in a similar way. So, using both the two medicines together may not be very beneficial and can increase the risk of side effects. However, there have been studies where Sebuxo when used with allopurinol in patients with refractory gout, was quite effective in providing relief. So, a combined use would be best decided by your treating doctor depending on your condition.
Sebuxo is not indicated in the treatment of kidney stones. However, some studies show that high renal uric acid excretion may precipitate the formation of calcium stones in the kidney and hence, suggest Sebuxo may have a role in the reduction of stone formation.
Q. Can I take Sebuxo with colchicine?
Sebuxo can be taken with colchicine. In the initial few days of starting Sebuxo, patients may experience an increase in gout attacks because of the movement of uric acid and colchicine and painkillers are given to these patients for the relief of pain and inflammation.
Q. Can I take Sebuxo with azathioprine?
Sebuxo should not be taken with azathioprine. Taking both the medicines together will increase the levels of azathioprine and can cause toxicity.
Sebuxo can generally be taken safely together with antibiotics. However, interactions can occur. Talk to your doctor about the right antibiotic therapy for your condition while you are also taking Sebuxo.
Use of Sebuxo is contraindicated in patients being treated with azathioprine, mercaptopurine, theophylline, and in patients who develop hypersensitivity to the drug.
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User Submitted Feedback For Sebuxo 40mg Tablet

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