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Samol 400mg/325mg Tablet contains two painkiller medicines. They work together to reduce pain, fever, and inflammation. It is used to treat many conditions such as headache, muscle pain, pain during periods, toothache, and joint pain.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 07 Jun 2026 | 12:54 AM (IST)
₹10.3 MRP ₹11.7212% off 
Gurgaon
 
 
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Samol 400mg/325mg Tablet is currently sold out
Same composition alternative:
Flexib 325 Tablet
₹32.2₹37
Available alternative from Alkem Laboratories
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Samol 400mg/325mg Tablet
Samol 400mg/325mg Tablet
strip of 10 tablets
₹10.3
₹11.72
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Same composition
Flexib 325 Tablet
Flexib 325 Tablet
strip of 20 tablets
Ibuprofen (400mg) + Paracetamol (325mg)
by Alkem Laboratories Ltd
Get by Sat, 18 Jul
₹32.2
₹1.37 per tablet

₹27.4

order for
₹1200

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General Information

Contains

Ibuprofen (400mg)+ Paracetamol (325mg)

Marketer

Sehat Pharma Pvt Ltd

Storage

Store below 30°C
The content is shown in English
Samol 400mg/325mg Tablet image
Samol 400mg/325mg Tablet image

Your child’s medicine at a glance

Take Samol 400mg/325mg Tablet with food to reduce the risk of an upset stomach. The dose and how often you need it will be decided by your doctor. Medicines used to treat pain are usually best taken at the first sign of pain. It is meant for short-term use only. Consult your doctor if the symptoms persist or worsen or if the medicine is required for use beyond 3 days. Side effects are rare if this medicine is used correctly, but it may cause heartburn, indigestion, nausea, vomiting, headache, and stomach pain in some people. Consult your doctor if any of these bother you or do not go away. Before taking Samol 400mg/325mg Tablet, let your doctor know if you are using blood-thinning medicines, or have asthma or any liver or kidney problems. It may affect the dose or suitability of this medicine. Pregnant or breastfeeding women should consult their doctor before taking this medicine. Let your doctor know about all the other medicines you are taking, as they may affect, or be affected by, this medicine. It is best to avoid drinking alcohol while using this medicine.

Uses of Samol 400mg/325mg Tablet in children

  • Pain relief : Samol 400mg/325mg Tablet helps relieve pain in conditions such as headache, body ache, muscle ache, toothache, menstrual cramps, and minor injuries.
  • Treatment of Fever : Samol 400mg/325mg Tablet helps relieve fever in conditions such as flu, viral infections, post-vaccination reactions, and other illnesses associated with fever.

Benefits of Samol 400mg/325mg Tablet for your child

Pain relief
Pain and inflammation can occur due to injury, strain, or underlying conditions. Samol 400mg/325mg Tablet works through different mechanisms to reduce pain, swelling, and inflammation. This provides effective relief from conditions such as headache, migraine, back pain, menstrual cramps, dental pain, and muscle aches.
Treatment of Fever
Fever is usually a sign of infection or inflammation in the body. Samol 400mg/325mg Tablet helps reduce high temperature by blocking chemical messengers that cause fever. This helps bring down the temperature and relieve associated symptoms such as body aches and discomfort. Take it as advised, using the lowest effective dose for the shortest duration.

Side effects of Samol 400mg/325mg Tablet in children

Samol 400mg/325mg Tablet does not pose serious side effects and is well-tolerated by children. In case the side effects do occur, they’re likely to subside once the body adapts to the medicine. Consult your child’s doctor if these side effects persist or bother your child. The most common side effects include-
Common side effects of Samol
  • Heartburn
  • Indigestion
  • Nausea
  • Stomach pain
  • Vomiting
  • Headache
  • Sleepiness

How can I give Samol 400mg/325mg Tablet to my child?

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Samol 400mg/325mg Tablet should be taken with or after food.

How Samol Tablet works

Samol 400mg/325mg Tablet is a combination of two medicines: Ibuprofen and Paracetamol. It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling).

All substitutes for Samol 400mg/325mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

IBUgesic Plus Tablet

by Cipla Ltd
₹1.83/tablet
78% costlier
<h3 class=bodySemiBold>IBUgesic Plus Tablet</h3>

Ibufyl Plus Tablet

by Leeford Healthcare Ltd
₹1.21/tablet
17% costlier
<h3 class=bodySemiBold>Ibufyl Plus Tablet</h3>

Flexib 325 Tablet

by Alkem Laboratories Ltd
₹1.61/tablet
56% costlier
<h3 class=bodySemiBold>Flexib 325 Tablet</h3>

Combiflam Tablet

by Sanofi Consumer Healthcare India Limited
₹2.62/tablet
154% costlier
<h3 class=bodySemiBold>Combiflam Tablet</h3>

Flexon Tablet

by Aristo Pharmaceuticals Pvt Ltd
₹2.07/tablet
101% costlier
<h3 class=bodySemiBold>Flexon Tablet</h3>

Quick tips

  • Take Samol 400mg/325mg Tablet with food to reduce stomach irritation.
  • Take Samol 400mg/325mg Tablet exactly as prescribed by your doctor, and avoid prolonged use without medical supervision.
  • Long-term or excessive use of Samol 400mg/325mg Tablet may increase the risk of stomach bleeding and kidney problems.
  • Do not take Samol 400mg/325mg Tablet with other medicines containing paracetamol without consulting your doctor.
  • Avoid taking Samol 400mg/325mg Tablet with other NSAIDs (such as ibuprofen, diclofenac, or naproxen) unless advised by your doctor.
  • Avoid alcohol while taking Samol 400mg/325mg Tablet, as it may increase drowsiness and the risk of stomach or liver problems.
  • Watch for warning signs such as severe stomach pain, vomiting blood, or black/tarry stools, and seek medical attention immediately.
  • Stay well hydrated while taking Samol 400mg/325mg Tablet, especially during fever or hot weather.
  • Inform your doctor if you have a history of asthma triggered by painkillers before taking Samol 400mg/325mg Tablet.
  • If dizziness occurs after taking Samol 400mg/325mg Tablet, avoid driving or activities requiring alertness.
  • Consult your doctor if pain or fever persists for more than a few days despite taking Samol 400mg/325mg Tablet

Safety advice

Kidney

Kidney

UNSAFE
Samol 400mg/325mg Tablet is unsafe to use in patients with kidney disease and should be avoided.
Liver

Liver

UNSAFE
Samol 400mg/325mg Tablet is unsafe to use in patients with liver disease and should be avoided.
All

Frequently asked questions

Samol 400mg/325mg Tablet may cause side effects such as nausea, vomiting, stomach pain, heartburn, diarrhea, or dizziness in some people. These effects are usually mild and may improve if the medicine is taken with food or milk. Some people may also feel tired or lightheaded. In rare cases, repeated use may affect kidney function or increase blood pressure, particularly in people who are dehydrated or have existing health problems. If side effects persist, worsen, or become severe, consult your doctor.
If you are using Samol 400mg/325mg Tablet for short-term pain or fever, you can usually stop taking it once your symptoms improve. However, if it has been prescribed for a condition that causes long-term pain, you should continue taking it for the duration recommended by your doctor. Always follow your doctor’s instructions before stopping any medication.
Samol 400mg/325mg Tablet is a medicine used for short-term relief of pain and fever. It is commonly prescribed for conditions such as headache, body aches, toothache, sore throat pain, muscle pain, joint pain, and inflammation-related discomfort. It works by lowering fever and reducing substances in the body that cause pain and swelling. While it helps relieve symptoms, it does not treat the underlying cause of the illness. If pain or fever continues, consult your doctor.
Samol 400mg/325mg Tablet should not be taken by people who are allergic to this medicine or to other similar pain relievers known as NSAIDs. It is also not recommended for individuals with stomach ulcers or stomach bleeding, severe liver or kidney disease, uncontrolled high blood pressure, or heart failure unless advised by a doctor. Long-term or improper use may harm the stomach, kidneys, or liver. Always inform your doctor about your medical history before taking Samol 400mg/325mg Tablet.
Samol 400mg/325mg Tablet should not be used to treat stomach pain without consulting a doctor. This medicine may increase the risk of stomach irritation and could worsen an underlying stomach condition, such as gastritis or ulcers. If you have persistent stomach pain, it is important to seek medical evaluation rather than self-medicating.
No, taking more than the recommended dose of Samol 400mg/325mg Tablet is not safe and will not necessarily provide better pain relief. Higher doses can increase the risk of side effects such as nausea, vomiting, stomach irritation, heartburn, and diarrhoea. Repeated or excessive use may also cause kidney damage or liver damage. If the prescribed dose does not control your pain or fever, consult your doctor instead of increasing the dose on your own.
Samol 400mg/325mg Tablet is generally not recommended during pregnancy unless your doctor specifically advises it. One of its components, ibuprofen, may affect the baby’s circulation and kidney function, especially during the later stages of pregnancy. Because of these risks, pregnant women should avoid self-medicating with this medicine. If you experience pain or fever during pregnancy, consult your doctor so a safer treatment option can be recommended.
Samol 400mg/325mg Tablet should only be given to children if advised by a doctor. Children require doses based on their age and weight, and certain medicine combinations may not be suitable for all ages. Although it can reduce fever and pain, improper use may increase the risk of overdose, especially if other medicines contain similar ingredients. Consult a doctor before giving Samol 400mg/325mg Tablet to a child.
Yes, ibuprofen can help reduce fever by lowering substances in the body called prostaglandins that are involved in inflammation and temperature regulation. However, fever may return until the underlying cause is treated. If fever lasts more than a few days or the person appears very unwell, medical advice should be sought.
It is best to avoid alcohol while taking Samol 400mg/325mg Tablet. Alcohol can increase the risk of stomach irritation and bleeding when combined with ibuprofen, and it may also increase the risk of liver damage when combined with paracetamol. If you regularly consume alcohol, discuss this with your doctor before taking Samol 400mg/325mg Tablet.
While taking Samol 400mg/325mg Tablet, avoid alcohol and avoid taking the medicine on an empty stomach. If spicy or heavy foods worsen acidity or heartburn, it may help to eat lighter meals during treatment. If you develop stomach pain, black stools, or vomiting that looks like blood, seek medical attention immediately.
Samol 400mg/325mg Tablet may temporarily reduce pain and inflammation from a tooth infection, but it does not treat the infection itself. Dental infections can spread and may cause swelling, fever, or a bad taste in the mouth. If you suspect a tooth infection, you should consult a dentist or doctor promptly for proper treatment.

Fact Box

Habit Forming

No

Therapeutic Class

PAIN ANALGESICS

Related lab tests

Complete Blood Count

References

  1. ScienceDirect. Paracetamol/Acetaminophen. [Accessed 23 Apr. 2019] (online) Available from:
  2. Acetaminophen and ibuprofen [Prescribing Information]. Greenville, NC: Catalent Greenville Inc.; 2023. [Accessed 14 Aug. 2024] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Sehat Pharma Pvt Ltd
Address: Lala Estate, Idar Highway Road, Savagadh, Himatnagar 383001, Gujarat.

Vendor Details

Country of origin: India

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