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RINIZIDE FORTE DT TABLET

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MRP: Rs. 35.50 for 1 strip(s) (10 tablet dt each)
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Composition for RINIZIDE FORTE DT TABLET

Isoniazid(150 mg),Pyrazinamide(100 mg),Rifampicin(500 mg)

food interaction for RINIZIDE FORTE DT TABLET

alcohol interaction for RINIZIDE FORTE DT TABLET

pregnancy interaction for RINIZIDE FORTE DT TABLET

lactation interaction for RINIZIDE FORTE DT TABLET

food
alcohol
pregnancy
lactation
Avoid Rinizide forte dt tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
UNSAFE
Rinizide forte dt tablet may cause symptoms such as flushing, increased heartbeat, nausea, thirst, chest pain and low blood pressure with alcohol (Disulfiram reactions).
UNSAFE
Rinizide forte dt tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
WEIGH RISKS VS. BENEFITS
Rinizide forte dt tablet is probably safe to use during breastfeeding. Please consult your doctor.
SAFE

SALT INFORMATION for RINIZIDE FORTE DT TABLET

Isoniazid(150 mg)

Uses

Isoniazid is used in the treatment and prevention of tuberculosis (TB).

How it works

Isoniazid belongs to a class of antituberculosis drugs. It suppresses the growth of tuberculosis causing bacteria (Mycobacterium tuberculosis). It interferes with the formation of the outer protective covering (cell wall) of the bacteria by inhibiting the synthesis of a chemical called mycolic acid an essential component of cell wall.

Common side effects

Vomiting, Nausea, Inflammation of the optic nerve of the eye, Peripheral neuropathy, Agranulocytosis (deficiency of granulocytes in the blood), Aplastic anemia, Diarrhoea, Dry mouth, Gastrointestinal disorder, Haemolytic anemia, Hepatitis (viral infection of liver)
Pyrazinamide(100 mg)

Uses

Pyrazinamide is used in the treatment of tuberculosis (TB).

How it works

Pyrazinamide is an antibiotic. It kills or stops growth of bacteria that causes tuberculosis (Mycobacterium tuberculosis).

Common side effects

Vomiting, Nausea, Increased sensitivity to light, Abnormal liver function tests, Anemia, Joint pain, Difficulty in urination, Jaundice, Loss of appetite, Skin rash
Rifampicin(500 mg)

Uses

Rifampicin is used in treatment of tuberculosis (TB) and leprosy.

How it works

Rifampin is an antibiotic and kills a wide range of infection causing bacteria (broad spectrum). It acts by blocking the activity of a bacterial enzyme called DNA-dependent RNA polymerase which is essential for important life processes in the bacteria, thereby killing the bacteria.

Common side effects

Vomiting, Nausea, Abnormal liver function tests, Acute renal failure, Irritation of ear, Allergic skin rash, Diarrhoea, Hemolytic anemia, Jaundice, Loss of appetite, Reduced blood platelets, Fever, Drowsiness, Headache

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Expert advice for RINIZIDE FORTE DT TABLET

  • Do not take isoniazid, if you have severe liver problems or if you have taken isoniazid in the past and it caused liver problems, fever, chills, joint pain, or severe allergic reaction.
  • Contact your doctor immediately, if you experience symptoms such unusual tiredness (fatigue), weakness, feeling of discomfort (malaise), loss of appetite (anorexia), urge to vomit (nausea) or vomiting while taking isoniazid. It indicates that you are progressing towards liver damage.
  • Do consult your doctor before taking isoniazid if you are aged above 35 years. The frequency of isoniazid related inflammation of liver (hepatitis) is higher in individuals older than 35 years of age. The doctor may advice measurement of blood levels of enzyme transferases before starting treatment with isoniazid.
  • Avoid drinking alcohol. It may increase your risk of liver damage while you are taking isoniazid.
  • Do consult your doctor before taking isoniazid, if you are pregnant or planning to become pregnant or are breastfeeding.
  • Isoniazid interacts with many drugs. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects.
  • Do not stop taking isoniazid without consulting your doctor.
  • If you forget to take a dose of Isoniazid, take it as soon as you remember. Do not double the dose to make up for the missed dose.

Frequently asked questions for RINIZIDE FORTE DT TABLET

Isoniazid

Q.Is isoniazid an antibiotic?
Isoniazid is an antibiotic used in the prevention and treatment of tuberculosis or TB (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body)

Q.Is isoniazid chemotherapy/chemotherapy drug?
Isoniazid is a primary antibiotic used for treatment of tuberculosis. Do not confuse it with chemotherapy or chemo drugs used for the treatment of cancer

Q.Is isoniazid bacteriostatic or bactericidal?
Isoniazid is a bacteriostatic antibiotic. It stops or suppresses growth of tuberculosis causing bacteria by interfering with the formation of protective outer covering (cell wall) which is essential for their growth

Q.Is isoniazid safe?
Yes. Isoniazid is safe if used at prescribed doses for the prescribed duration as advised by your doctor

Q.Is isoniazid a MAOI?
Isoniazid has very weak inhibitory activity on enzymes monoamine oxidases (MAO); however it is not used as a monoamine oxidase inhibitor (MAOI)

Q.Is isoniazid a sulfa drug?
No. The chemical structure and mechanism of action of isoniazid is different from sulfa drugs

Q.Is isoniazid an inducer or inhibitor?
Isoniazid is an inhibitor (decreases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body

Q.Can I take isoniazid with ibuprofen/Benadryl/Nyquil/Aleve/Mucinex/amoxicillin?
There no known serious drug interactions of isoniazid with ibuprofen, paracetamol (trade name: Tylenol), naproxen (trade name: Aleve), amoxicillin or any active drug present in Nyquil or Mucinex. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects

Q.Does isoniazid cause weight loss/weight gain/hair loss/diarrhea/affect menstruation?
Changes in body weight (gain/loss), hair loss, diarrhea or changes in menstruation are not among the known side effects of isoniazid. You may experience few of these side effects while on multi drug (including isoniazid) treatment for tuberculosis

Q.Does isoniazid cause acne/make you tired/cause constipation?
You may experience unusual tiredness, constipation or acne while on treatment with isoniazid. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects

Q.Does isoniazid affect birth control?
Isoniazid has no known interaction with commonly used oral contraceptives (birth control pills). However, multidrug treatment for tuberculosis contains active drug rifampin that decreases the effectiveness of oral contraceptives and hampers birth control.

Pyrazinamide

Q.What is pyrazinamide and what is it used for?
Pyrazinamide is an antibiotic. It is used in combination with other antibiotics in the treatment of tuberculosis

Q.Is pyrazinamide bactericidal?
Pyrazinamide is both a bacteriostatic and a bactericidal antibiotic. It stops the growth of bacteria (bacteriostatic) in certain cases and kills (bactericidal) the tuberculosis causing bacteria in other cases

Q.How does pyrazinamide work/treat tuberculosis?
Pyrazinamide kills or stops growth of bacteria that causes tuberculosis (Mycobacterium tuberculosis). The exact mechanism of action for pyrazinamide is not known

Q.How does pyrazinamide cause hyperuricemia and gout?
Following oral intake of pyrazinamide, it gets converted in the body to pyrazinoic acid (active chemical form of pyrazinamide). Pyrazinoic acid blocks the excretion of urates (salt form of uric acid) by the kidneys. This causes an increase in blood levels of uric acid (hyperuricemia). Excess uric acid accumulation between joints causes pain, swelling, redness and stiffness in joints (gout).

Rifampicin

Q.Is rifampin and rifampicin same?
Yes. Rifampin (nomenclature in the United States) and rifampicin (nomenclature in Britain) is the same antibiotic commonly used in the treatment of tuberculosis and leprosy

Q.Is rifampin a penicillin/amoxicillin/sulfa drug?
No. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has a structure and mechanism of action different from penicillin or amoxicillin (amoxicillin belongs to the class of penicillin antibiotics). The chemical structure and mechanism of action of rifampin is different from sulfa drugs

Q.Is rifampin bacteriostatic or bactericidal?
Rifampin is a bactericidal drug. It acts by blocking the activity of a bacterial enzyme called DNA-dependent RNA polymerase which essential for important life processes in the bacteria, thereby killing the bacteria

Q.Is rifampin an inducer or inhibitor?
Rifampin is an inducer (increases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body

Q.What is R-cin 600 used for?
R-cin 600 is a trade name for active drug rifampin 600 mg. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It is also used in the prevention of meningococcal meningitis and Haemophilus influenza infections. It may also be used in combination with other drugs to treat infections-Brucellosis, Legionnaires disease or serious staphylococcal infections

Q.What is R-cinex/Macox plus/R-cinex 600?
R-cinex and Macox plus are trade names for a combination of active drugs rifampin and isoniazid. It is used in the treatment of tuberculosis. R-cinex 600 and Macox plus contains 600 mg of active drug rifampin and 300 mg of active drug isoniazid

Q.Can I take rifampin with ibuprofen/acetaminophen (Tylenol)?
Rifampin has no known serious drug interaction with ibuprofen or acetaminophen (trade name: Tylenol). Inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects

Q.Does rifampin cause weight gain/weight loss/ hair loss/ constipation/ yeast infection?
No. Changes in body weight, hair loss or triggering constipation are not among the known side effects of rifampin. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has no known effect on causing yeast infections

Q.Does rifampin cause headaches?
Yes. Headache is a possible side effect of rifampin

Q.Does rifampin change urine color/turn urine orange?
Yes. Taking rifampin may change the color of your urine (skin, sweat, saliva, tears and feces) to brownish-red or orange. This effect is not harmful

Q.Does rifampin cause liver damage?
Rifampin is safe when used at prescribed doses for the prescribed duration. Constant monitoring of liver function is important while on treatment with rifampin. Taking drugs like saquinavir, ritonavir with rifampin can cause severe liver damage. Do consult your doctor if you have any liver problem before taking rifampin.

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Content on this page was last updated on 30 November, 2015, by Dr. Varun Gupta (MD Pharmacology)