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Isoniazid + Pyrazinamide + Rifampicin

Information about Isoniazid + Pyrazinamide + Rifampicin

Isoniazid + Pyrazinamide + Rifampicin Uses

Isoniazid+Pyrazinamide+Rifampicin is used in the treatment of tuberculosis.

How Isoniazid + Pyrazinamide + Rifampicin works

Isoniazid + Pyrazinamide + Rifampicin is a combination of three medicines: Isoniazid , Pyrazinamide and Rifampicin which treat tuberculosis. Isoniazid prevents the TB bacteria from forming their own protective covering while Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by these bacteria to make essential proteins and to reproduce. Together, they kill the bacteria and eradicate the infection. Pyrazinamide , on the other hand works by slowing the growth of these bacteria.

Common side effects of Isoniazid + Pyrazinamide + Rifampicin

Nausea, Vomiting, Peripheral neuropathy (tingling and numbness of feet and hand), Abdominal pain, Skin rash, Itching, Hepatitis (viral infection of liver), Dizziness, Lethargy, Low blood platelets

Severe side effects of Isoniazid + Pyrazinamide + Rifampicin

Fever, Agranulocytosis (deficiency of granulocytes in the blood), Aplastic anemia, Deafness, Ringing in ear, Vertigo, Hypoglycemia (low blood glucose level), Breast enlargement in male, Optic neuritis, Pseudomembranous colitis, Pseudoadrenal crisis, Acute renal failure, Toxic epidermal necrolysis, Stevens-Johnson syndrome, Drug allergy, Hepatomegaly (enlarged liver), Enlarged spleen, Discomfort when urinating, Decreased white blood cell count (lymphocytes), Decreased white blood cell count (neutrophils), Hypersensitivity, Gout precipitation, Pneumonitis
Written By
PhD (Pharmacology), PGDPRA
Reviewed By
MD Pharmacology, MBBS
Last updated
05 Aug 2022 | 11:16 AM (UTC)

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Available Medicine for Isoniazid + Pyrazinamide + Rifampicin

Macox-ZHMacleods Pharmaceuticals Pvt Ltd
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R-Cinex ZLupin Ltd
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Akurit Z KidLupin Ltd
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Vicox 3Shrinivas Gujarat Laboratories Pvt Ltd
35 to ₹482 variant(s)
RF 3 ForteSunij Pharma Pvt Ltd
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RF 3Sunij Pharma Pvt Ltd
311 variant(s)
RifaterSanofi India Ltd
181 variant(s)
Anticox ZTorrent Pharmaceuticals Ltd
121 variant(s)
Coxbact 3Alpic Remedies Ltd
73 to ₹802 variant(s)

Expert advice for Isoniazid + Pyrazinamide + Rifampicin

  • Isoniazid + Pyrazinamide + Rifampicin should be taken on an empty stomach but at the same time every day.
  • Do not skip any doses and finish the full course of treatment even if you feel better.
  • It may cause dizziness. Don't drive or do anything that requires mental focus until you know how Isoniazid + Pyrazinamide + Rifampicin affects you.
  • Avoid drinking alcohol while taking this medicine as this may increase the risk of side effects on the liver.
  • Avoid taking hormone-based birth control methods as Isoniazid + Pyrazinamide + Rifampicin may decrease their effectiveness.
  • Your doctor may monitor your liver function, vision and thyroid function while on treatment with this medicine.


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