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Isoniazid + Pyrazinamide + Rifampicin

Information about Isoniazid + Pyrazinamide + Rifampicin

Isoniazid + Pyrazinamide + Rifampicin Uses

Isoniazid+Pyrazinamide+Rifampicin is used in the treatment of tuberculosis.

How Isoniazid + Pyrazinamide + Rifampicin works

Isoniazid + Pyrazinamide + Rifampicin is a combination of three medicines: Isoniazid , Pyrazinamide and Rifampicin which treat tuberculosis. Isoniazid prevents the TB bacteria from forming their own protective covering while Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by these bacteria to make essential proteins and to reproduce. Together, they kill the bacteria and eradicate the infection. Pyrazinamide , on the other hand works by slowing the growth of these bacteria.

Common side effects of Isoniazid + Pyrazinamide + Rifampicin

Nausea, Vomiting, Fever, Rash, Dark colored urine, Sweating, Increased sputum production, Salivation, Watery eyes, Peripheral neuropathy (tingling and numbness of feet and hand), Increased liver enzymes, Jaundice, Increased uric acid level in blood, Gout
Written By
PhD (Pharmacology), PGDPRA
Reviewed By
MD (Pharmacology), MBBS
Last updated:
12 Apr 2021 | 11:24 AM (UTC)

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Available Medicine for Isoniazid + Pyrazinamide + Rifampicin

Macox-ZHMacleods Pharmaceuticals Pvt Ltd
43 to ₹532 variant(s)
R-Cinex ZLupin Ltd
15 to ₹352 variant(s)
561 variant(s)
Akurit Z KidLupin Ltd
101 variant(s)
Vicox 3Shrinivas Gujarat Laboratories Pvt Ltd
35 to ₹482 variant(s)
RF 3 ForteSunij Pharma Pvt Ltd
351 variant(s)
RF 3Sunij Pharma Pvt Ltd
311 variant(s)
MontoripShreya Life Sciences Pvt Ltd
16 to ₹423 variant(s)
Binex ZAlbert David Ltd
10 to ₹222 variant(s)
RifaterSanofi India Ltd
181 variant(s)

Expert advice for Isoniazid + Pyrazinamide + Rifampicin

  • Isoniazid + Pyrazinamide + Rifampicin should be taken on an empty stomach but at the same time every day.
  • Do not skip any doses and finish the full course of treatment even if you feel better.
  • It may cause dizziness. Don't drive or do anything that requires mental focus until you know how Isoniazid + Pyrazinamide + Rifampicin affects you.
  • Avoid drinking alcohol while taking this medicine as this may increase the risk of side effects on the liver.
  • Avoid taking hormone-based birth control methods as Isoniazid + Pyrazinamide + Rifampicin may decrease their effectiveness.
  • Your doctor may monitor your liver function, vision and thyroid function while on treatment with this medicine.


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