Isoniazid + Pyrazinamide + Rifampicin

Isoniazid+Pyrazinamide+Rifampicin is used in the treatment of tuberculosis.

Isoniazid + Pyrazinamide + Rifampicin is a combination of three medicines: Isoniazid , Pyrazinamide and Rifampicin which treat tuberculosis. Isoniazid prevents the TB bacteria from forming their own protective covering while Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by these bacteria to make essential proteins and to reproduce. Together, they kill the bacteria and eradicate the infection. Pyrazinamide , on the other hand works by slowing the growth of these bacteria.

Nausea, Vomiting, Peripheral neuropathy (tingling and numbness of feet and hand), Abdominal pain, Skin rash, Itching, Hepatitis (viral infection of liver), Dizziness, Lethargy, Low blood platelets

Fever, Agranulocytosis (deficiency of granulocytes in the blood), Aplastic anemia, Deafness, Ringing in ear, Vertigo, Hypoglycemia (low blood glucose level), Breast enlargement in male, Optic neuritis, Pseudomembranous colitis, Pseudoadrenal crisis, Acute renal failure, Toxic epidermal necrolysis, Stevens-Johnson syndrome, Drug allergy, Hepatomegaly (enlarged liver), Enlarged spleen, Discomfort when urinating, Decreased white blood cell count (lymphocytes), Decreased white blood cell count (neutrophils), Hypersensitivity, Gout precipitation, Pneumonitis