
Pyronil Syrup
Written By Dr. Lipika Khurana, PGDHHM, BDS
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS
Last updated on 19 Sep 2025 | 03:31 PM (IST)
Pyronil Syrup is commonly prescribed in children to treat fever, body ache as well as allergic symptoms associated with common cold like runny nose, cough, sneezing, and watery eyes. Also, it is one of the commonly used medicines in chickenpox for symptomatic relief.
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General Information
Contains
Paracetamol (125mg)+ Promethazine (2.5mg)
Marketer
Key West Medicines Pvt Ltd
Storage
Store below 30°C
The content is shown in English



Your child’s medicine at a glance
Give Pyronil Syrup to your child by mouth with or without food, preferably at a fixed time. Children often have a sensitive stomach and complain of stomach upset while taking medicines. Prefer giving this medicine with food if this happens. Always remember that the dosing schedule provided by your child’s doctor depends on the type of symptoms your child has, so make sure to follow the prescribed dose, time, and way strictly. If your child vomits within 30 minutes of taking this medicine, give the same dose again.
Some of the minor and temporary side effects that your child may experience while taking this medicine include vomiting, diarrhea, nausea, dizziness, sleepiness, and skin rash. Usually, these episodes subside once your child’s body adapts to the medicine. In case these side effects persist or become bothersome for your child, consult your child’s doctor without any delay.
Share your child’s complete medical history with your child’s doctor, including any ongoing medicine regime or history of any allergy, heart problem, blood disorder, birth defects, airway obstruction, lung anomaly, skin disorder, liver impairment, and kidney malfunction. This information is critical for dose alterations and for planning your child’s overall treatment.
Some of the minor and temporary side effects that your child may experience while taking this medicine include vomiting, diarrhea, nausea, dizziness, sleepiness, and skin rash. Usually, these episodes subside once your child’s body adapts to the medicine. In case these side effects persist or become bothersome for your child, consult your child’s doctor without any delay.
Share your child’s complete medical history with your child’s doctor, including any ongoing medicine regime or history of any allergy, heart problem, blood disorder, birth defects, airway obstruction, lung anomaly, skin disorder, liver impairment, and kidney malfunction. This information is critical for dose alterations and for planning your child’s overall treatment.
Uses of Pyronil Syrup in children
Benefits of Pyronil Syrup for your child
Treatment of Fever
Pyronil Syrup helps reduce high body temperature and relieve headache, body ache, and malaise. It works by blocking the pain and fever pathways in the brain responsible for the rise in body temperature.
Pyronil Syrup helps reduce high body temperature and relieve headache, body ache, and malaise. It works by blocking the pain and fever pathways in the brain responsible for the rise in body temperature.
Treatment of Common cold
Pyronil Syrup is a combination medicine that effectively relieves symptoms of the common cold, such as a blocked nose, runny nose, watery eyes, sneezing, and congestion or stuffiness. It helps loosen thick mucus, making it easier to cough out. It also shrinks the blood vessels and provides rapid relief that lasts for several hours. These actions make breathing easier.
Pyronil Syrup is safe and effective. It usually starts to work within a few minutes, and the effects can last up to several hours. Take it as prescribed by your doctor, and do not stop using it unless you are advised otherwise.
Pyronil Syrup is a combination medicine that effectively relieves symptoms of the common cold, such as a blocked nose, runny nose, watery eyes, sneezing, and congestion or stuffiness. It helps loosen thick mucus, making it easier to cough out. It also shrinks the blood vessels and provides rapid relief that lasts for several hours. These actions make breathing easier.
Pyronil Syrup is safe and effective. It usually starts to work within a few minutes, and the effects can last up to several hours. Take it as prescribed by your doctor, and do not stop using it unless you are advised otherwise.
Side effects of Pyronil Syrup in children
Pyronil Syrup does not pose serious side effects and is well-tolerated by children. In case the side effects do occur, they’re likely to subside once the body adapts to the medicine. Consult your child’s doctor if these side effects persist or bother your child. The most common side effects include-
Common side effects of Pyronil
- Vomiting
- Nausea
- Diarrhea
- Rash
- Dizziness
How can I give Pyronil Syrup to my child?
Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Pyronil Syrup may be taken with or without food, but it is better to take it at a fixed time.
How Pyronil Syrup works
Pyronil Syrup contains two active ingredients: paracetamol, and promethazine. These ingredients together relieve common cold symptoms. Promethazine is an antiallergic that relieves allergy symptoms like runny nose, watery eyes, and sneezing. Paracetamol is an analgesic (pain reliever) and antipyretic (fever reducer). It blocks the release of certain chemical messengers in the brain that are responsible for pain and fever.
Quick tips
- Pyronil Syrup may make your child feel sleepy. Ensure your child takes extra care when taking part in physical activities.
- Never combine Pyronil Syrup with other cold and flu medicines as that may lead to side effects.
- Stop Pyronil Syrup and immediately report to the doctor if your child develops an itchy rash, facial swelling, or breathing difficulties.
- Practice self-care tips:
- Keep the surroundings and surfaces neat and clean to avoid exposure to allergens
- Make sure your child maintains proper hygiene and sanitation to avoid infection
- Ensure your child takes enough rest to expedite recovery.
Safety advice

Kidney
SAFE IF PRESCRIBED
Pyronil Syrup is safe to use in patients with kidney disease. No dose adjustment of Pyronil Syrup is recommended.
However, caution is advised in patients with severe kidney disease as it may cause excessive sleepiness in them.
However, caution is advised in patients with severe kidney disease as it may cause excessive sleepiness in them.

Liver
CAUTION
Pyronil Syrup should be used with caution in patients with liver disease. Dose adjustment of Pyronil Syrup may be needed. Please consult your doctor.
The use of Pyronil Syrup is not recommended in children with severe liver disease and active liver disease.
The use of Pyronil Syrup is not recommended in children with severe liver disease and active liver disease.
Frequently asked questions
Pyronil Syrup should not be used in children who are less than 2 years of age because it has the potential of causing fatal respiratory depression.
Prolonged or excess intake of Pyronil Syrup can put your child at risk of developing serious side effects like bradycardia, decreased blood pressure, confusion, delirium, disorientation, dizziness, drowsiness, and hallucinations. Always stick to the prescribed dose. To pour out the right dose, use the calibrated cup provided with the medicine by the manufacturer. Do not use a kitchen teaspoon as it will not give the correct estimate.
Pyronil Syrup usually starts working within 30 to 60 minutes of intake and shows its peak effect within 3 to 4 hours. Your child may start to feel better after a few doses. In case the pain or fever persists longer, consult your child’s doctor immediately.
Keep Pyronil Syrup out of the reach and sight of children to avoid any accidental intake. Also, it should be stored at room temperature, in a dry place, away from direct heat and light.
Pyronil Syrup may cause mild drowsiness, making your child feel sleepy. So, be cautious and never give this medicine if your child is suffering from a sleep disorder as this medicine can mask the symptoms of underlying sleep disorders like insomnia. It is always best to consult your child’s doctor before giving this medicine to your child.
It is advised to use Pyronil Syrup with caution if the child has malnutrition, G6PD deficiency, liver disease, or any medicinal allergy. So, do not hesitate to share your child’s complete medical history with the doctor as that will help the doctor decide whether the medicine is safe for your child or not.
Do not delay calling your child’s doctor if your child starts to show side effects like irregular heartbeat, complaints of urinary retention, vision problem, muscle spasm, irregular bodily movements, and sudden weakness.
Fact Box
Habit Forming
No
Therapeutic Class
RESPIRATORY
Related lab tests
References
- Paracetamol, promethazine hydrochloride, dextromethorphan hydrobromide [Patient Information Leaflet]. Tipperary, Ireland: Pinewood Laboratories Ltd.; 2020. [Accessed 20 Jan. 2021] (online) Available from:
- Promethazine HCl. Philadelphia, PA: Wyeth Pharmaceuticals Inc.; 2004. [Accessed 20 Jan. 2021] (online) Available from:
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Marketer details
Name: Key West Medicines Pvt Ltd
Address: C-52, Hosiery Complex, Noida Phase 2, Noida - 201305
Address: C-52, Hosiery Complex, Noida Phase 2, Noida - 201305
Vendor Details
Country of origin: India
Lab tests offered by us
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- PPBS (Postprandial Blood Sugar)
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid -19 test- RT PCR
- LFT (Liver Function Test)
- KFT (Kidney Function Test)
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid, Serum
- Vitamin B12
- CRP (C-Reactive Protein), Quantitative
- Urine C/S (Urine Culture and Sensitivity)
- Serum Electrolytes
- Serum Calcium
- Serum Creatinine
- Diabetes Screening (HbA1C & Fasting Sugar)
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hb (Hemoglobin)
- Complete Hemogram (CBC & ESR)
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