Pristine 25mg Tablet is a medicine used in the treatment of uterine fibroids, noncancerous growths in the uterus that can cause heavy bleeding, pain, and pressure. It blocks the hormone progesterone, which fibroids rely on to grow, helping shrink them and ease symptoms like heavy bleeding and pelvic pain.

Take Pristine 25mg Tablet exactly as prescribed by your doctor. It can be taken with or without food. Try to take it at the same time every day to help build a routine. Follow all your doctor’s instructions while taking this medicine. Your doctor may also ask for regular check-ups or ultrasounds to see how well the medicine is working and to monitor for any side effects. Make sure to attend all appointments.

Some common side effects of Pristine 25mg Tablet include hot flushes, nausea, headache, dizziness, and tiredness. You may experience lighter periods, or they may stop for a while. These side effects are usually mild and go away on their own. If you notice unusual or heavy bleeding, persistent stomach pain, or any serious discomfort, let your doctor know immediately.

Before starting Pristine 25mg Tablet, inform your doctor if you have liver problems, anemia, or any bleeding disorders. This medicine is not recommended for women who are pregnant or planning to become pregnant, as it can harm the pregnancy. While on treatment, use a nonhormonal method of contraception to prevent pregnancy. Avoid using it along with other hormone treatments unless your doctor advises.

Uses of Pristine Tablet

Treatment of Uterine fibroids

Benefits of Pristine Tablet

In Treatment of Uterine fibroids

Pristine 25mg Tablet helps reduce the size of the fibroids and control symptoms like heavy menstrual bleeding, pelvic pain, and pressure in women with uterine fibroids. Easing these symptoms helps improve energy levels, reduces the need for frequent sanitary product changes, and lowers the risk of anemia. Pristine 25mg Tablet allows women to manage their condition without undergoing invasive procedures, making daily life more comfortable and predictable. Overall, this medicine helps restore a better quality of life by giving patients more control over their bodies and daily routines.

Side effects of Pristine Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Pristine

Hot flashes
Nausea
Headache
Tiredness
Dizziness

How to use Pristine Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pristine 25mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Pristine Tablet works

Pristine 25mg Tablet works by blocking the action of progesterone, a hormone that plays a key role in the growth of uterine fibroids. Inhibiting progesterone receptors helps reduce fibroid size and helps control symptoms like heavy bleeding and pain associated with the condition.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Pristine 25mg Tablet. Please consult your doctor.

Pregnancy

UNSAFE

Pristine 25mg Tablet is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Pristine 25mg Tablet during breastfeeding is not available. Please consult your doctor.

Driving

CONSULT YOUR DOCTOR

It is not known whether Pristine 25mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney

CONSULT YOUR DOCTOR

There is limited information available on the use of Pristine 25mg Tablet in patients with kidney disease. Please consult your doctor.

Liver

CAUTION

Pristine 25mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Pristine 25mg Tablet may be needed. Please consult your doctor.

What if you forget to take Pristine Tablet?

If you miss a dose of Pristine 25mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Pristine 25mg Tablet

₹39.5/Tablet

Fibroease 25mg Tablet

Akumentis Healthcare Ltd

₹70.5/tablet

78% costlier

Fibristone 25 Tablet

Jagsonpal Pharmaceuticals Ltd

₹60.7/tablet

54% costlier

Mifeone 25mg Tablet

Pharmanova India Drugs Pvt Ltd

₹57.86/tablet

46% costlier

Minifibro 25mg Tablet

Akumentis Healthcare Ltd

₹53.1/tablet

34% costlier

Goefibro-M 25 Tablet

Koye Pharmaceuticals Pvt ltd

₹50.5/tablet

28% costlier

View all substitutes

Quick tips

Take Pristine 25mg Tablet at the same time every day to help maintain consistent levels in your body and avoid missed doses.
Do not stop taking the medicine on your own, even if symptoms improve. Always follow your doctor’s advice on how long to continue treatment.
Use nonhormonal contraception like condoms or a copper intrauterine device (IUD) during treatment, as this medicine can affect pregnancy.
Inform your doctor if you experience heavy or prolonged bleeding, abdominal pain, or missed periods beyond what is expected during treatment.
Attend all follow-up appointments, including ultrasound scans or blood tests, to monitor fibroid size and check for side effects early.
Eat a balanced diet rich in iron (like green leafy vegetables, lentils, or iron-fortified cereals) to help manage or prevent anemia, especially if you had heavy bleeding before starting treatment.

Fact Box

Chemical Class

Oxosteroid

Habit Forming

Therapeutic Class

GYNAECOLOGICAL

Action Class

Antiprogestins

Patient concerns

I am suffering with uterine fibroids & get it treated.

Dr. Megha Tuli

Obstetrics and Gynaecology

Treatment would depend on size and site of the fibroids, age and parity and also on symptoms. A detailed evaluation would be required. I suggest you visit a gynaecologist in your area or you could visit me at my clinic in Gurgaon.

How to get treated for uterine fibroids Is fibroid reason for infertility

Dr. Sonu Balhara Ahlawat

Obstetrics and Gynaecology

Maybe it can cause but site of fibroid and the size is important

Primi with 3 uterine fibroids, on duphaston 10mg bid. Respected madam/sir I am an mbbs doctor, i m pregnant,primi, 4 months pregnant I have 3 uterine fibroids, posterior wall utero cervical junction(85.7*68.9mm), posterior wall fundal right lateral wall(30.9*25.3mm & My doctor says i will have to keep taking duphaston. I am having severe lower abdominal pain since 7days, my sonography is normal, blood and urine reports are normal as well. I would be extremely thankful if u would guide me. Thank u

Dr. Suman Rao

Obstetrics and Gynaecology

Rule out any fibroid degeneration. You can switch to proluton inj. Usually I prescribe Duphaston till 12 weeks only.

What is Pristine 25mg Tablet used for?

Pristine 25mg Tablet is used to manage symptoms of uterine fibroids, such as heavy or prolonged menstrual bleeding, lower abdominal pain, and pressure in the pelvic area. It helps improve quality of life by shrinking the fibroids and making the symptoms more manageable without the need for surgery in many cases.

How long does it take for Pristine 25mg Tablet to show results?

You may start to notice a reduction in bleeding and discomfort within a few weeks of starting treatment. However, significant shrinkage in fibroid size usually takes a few months. Your doctor will monitor your response to treatment and may adjust the dose or duration based on how well the medicine is working for you.

Will my periods stop while taking Pristine 25mg Tablet?

Yes, many women experience lighter periods or even temporary absence of menstruation while on Pristine 25mg Tablet. This is a common effect and usually not a cause for concern. Once the treatment is stopped, your periods typically return to normal within a few weeks.

Can Pristine 25mg Tablet cure fibroids completely?

Pristine 25mg Tablet can control symptoms and reduce fibroid size during treatment, but it does not cure fibroids permanently. The fibroids may grow back or symptoms may return after stopping the medicine. However, for many women, it offers a valuable non-surgical option to manage the condition effectively.

Is Pristine 25mg Tablet a hormonal medicine?

Pristine 25mg Tablet is not a hormone itself, but it acts on hormone receptors. It blocks the progesterone receptors in the uterus, which helps reduce the effects of progesterone on fibroid growth and menstrual bleeding.

Can I get pregnant while taking Pristine 25mg Tablet?

Yes, pregnancy is still possible while taking Pristine 25mg Tablet. However, the medicine can harm an early pregnancy. Use a non-hormonal contraceptive method (like condoms or copper IUD) during treatment, unless you are specifically advised otherwise by your doctor.

Can I take Pristine 25mg Tablet with other medicines?

Some medicines may interfere with how Pristine 25mg Tablet works. Always inform your doctor about all the medicines, supplements, or herbal products you are using. This helps avoid harmful interactions and ensures that the treatment remains safe and effective.

Do I need regular check-ups during treatment?

Yes, regular follow-ups are important while you're taking Pristine 25mg Tablet. Your doctor may recommend blood tests or ultrasound scans to check the size of the fibroids and ensure that your liver and overall health are not affected by the medicine. These check-ups help your doctor decide how long you should continue the treatment and whether any changes are needed.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Levin ER, Hammes SR. Estrogens and Progestins. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1184-85.
Masters SB. Hypothalmic & Pituitary Hormones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 716-17.
Kulshrestha V, Kriplani A, Agarwal N, et al. Low dose mifepristone in medical management of uterine leiomyoma - an experience from a tertiary care hospital from north India. Indian J Med Res. 2013;137(6):1154-62. [Accessed 30 Jun. 2025] (online) Available from:
Seth S, Goel N, Singh E, et al. Effect of mifepristone (25 mg) in treatment of uterine myoma in perimenopausal woman. J Midlife Health. 2013 Jan;4(1):22-6. [Accessed 30 Jun. 2025] (online) Available from:
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