Pretrex 100mg Injection

Written By Dr. Sakshi Jain, MS, BDS

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 31 Mar 2026 | 02:31 PM (IST)

Pretrex 100mg Injection is used in the treatment of non-small cell lung cancer and malignant pleural mesothelioma.

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Stored between 2-8°C

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General Information

Contains

Pemetrexed (100mg)

Marketer

Premedium Pharmaceuticals Pvt Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Pretrex 100mg Injection is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include nausea, vomiting, loss of appetite, and hair loss. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver and blood uric acid levels.

Before taking it, tell your doctor if have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using.This medicine is not recommended during pregnancy or while breastfeeding. Use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Pretrex Injection

Non-small cell lung cancer
Malignant pleural mesothelioma

Benefits of Pretrex Injection

Non-small cell lung cancer
Non-small cell lung cancer is one of the major kinds of lung cancer and it affects both smokers as well as non-smokers. Pretrex 100mg Injection helps treat non-small cell lung cancer and may be given alone or in combination with other medicines. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Malignant pleural mesothelioma
Malignant pleural mesothelioma is a form of cancer that develops in the lungs and the inner side of the ribs. It is a very aggressive form of lung cancer. Pretrex 100mg Injection is used along with some other medicines to treat this cancer. It kills the cancer cells, and prevents the further multiplication of cancer cells. This restricts the spread of cancer to other unaffected areas. Follow your doctor’s instructions carefully and consult your doctor if you have any doubts.

Side effects of Pretrex Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Pretrex

Nausea
Vomiting
Sore throat
Loss of appetite
Stomatitis (Inflammation of the mouth)
Hair loss
Low blood platelets
Rash
Fatigue
Anemia (low number of red blood cells)
Diarrhea
Decreased white blood cell count (neutrophils)
Neuropathy

How to use Pretrex Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Pretrex Injection works

Pretrex 100mg Injection interferes with the growth of DNA and RNA of the cancer cells by substituting their building blocks. It prevents the cancer cells from growing and multiplying.

All substitutes for Pretrex 100mg Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Pretrex 100mg Injection. Please consult your doctor.

Pregnancy

UNSAFE

Pretrex 100mg Injection is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

CAUTION

Pretrex 100mg Injection should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

CONSULT YOUR DOCTOR

It is not known whether Pretrex 100mg Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Pretrex 100mg Injection may make you feel tired and this may affect your ability to drive.

Kidney

CAUTION

Pretrex 100mg Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Use of Pretrex 100mg Injection is not recommended in patients with moderate to severe kidney disease.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Pretrex 100mg Injection in patients with liver disease.

Interaction with drugs

Taking Pretrex with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Cisplatin (Injection Route)

If concurrent use is essential, watch out for symptoms such as nausea, vomiting, diarrhea, mouth sores, fatigue, hair loss, rash, numbness or tingling in the hands & feet and consult your doctor if you experience them. They may adjust the doses as per the observations. Pemetrexed may increase the metabolism of Cisplatin.

Severe

Cholera Vaccine (Inactivated) (Oral Route)

Pemetrexed may reduce efficacy of Cholera Vaccine (Inactivated). Pemetrexed may reduce efficacy of Cholera Vaccine (Inactivated).

Severe

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Pemetrexed may reduce efficacy of Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted). Pemetrexed may reduce efficacy of Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted).

Severe

Ibuprofen (Oral Route)

Ibuprofen may increase the effect of Pemetrexed. Ibuprofen may increase the effect of Pemetrexed.

Severe

Ibuprofen (Injection Route)

Ibuprofen may increase the effect of Pemetrexed. Ibuprofen may increase the effect of Pemetrexed.

Frequently asked questions

Is Pretrex 100mg Injection a vesicant?

No. Pretrex 100mg Injection is not a vesicant.

Is Pretrex 100mg Injection safe?

Pretrex 100mg Injection is safe if used at prescribed doses for the prescribed duration as advised by your doctor.

Does Pretrex 100mg Injection cause hair loss?

Yes. Pretrex 100mg Injection is a prescription chemotherapy medication and hair loss is one of the possible side effects.

Fact Box

Chemical Class

Glutamic acid derivative

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Antimetabolites

References

Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 946.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1077.
Pemetrexed disodium. Basingstoke, Hampshire: Eli Lilly and Company Limited; 2004 [revised 10 Jan. 2019]. [Accessed 28 Jan. 2019] (online) Available from:
Pemetrexed. Indianapolis, Indiana: Lilly USA; 2004 [revised Sep. 2013]. [Accessed 26 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 26 Mar. 2019] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Premedium Pharmaceuticals Pvt Ltd
Address: 207 SUCHET CHAMBERS, 1224/5 BANK STREET, KAROL BAGH, NEW DELHI Central Delhi DL 110005 IN

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Pretrex 100mg Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Pretrex Injection

Benefits of Pretrex Injection

Side effects of Pretrex Injection

How to use Pretrex Injection

How Pretrex Injection works

All substitutes for Pretrex 100mg Injection

Alimta 100mg Injection

Pemzonex 100mg Injection

Medipem 100mg Injection

Adpem 100mg Injection

Pemetomed 100mg Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Cisplatin (Injection Route)

Cholera Vaccine (Inactivated) (Oral Route)

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Ibuprofen (Oral Route)

Ibuprofen (Injection Route)

Frequently asked questions

Is Pretrex 100mg Injection a vesicant?

Is Pretrex 100mg Injection safe?

Does Pretrex 100mg Injection cause hair loss?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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