Polyxx E 4.5M IU Injection

Written By Dr. Lipika Khurana, PGDHHM, BDS

Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS

Last updated on 25 Nov 2025 | 03:05 PM (IST)

Polyxx E 4.5M IU Injection is an antibiotic that fights bacteria. It is used to treat severe bacterial infections of the body. It is commonly used for critically ill patients admitted to the hospital.

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₹3291 MRP ₹364110% off

Polyxx E 4.5M IU Injection is currently sold out

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Coly Monas 4.5 Injection

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Polyxx E 4.5M IU Injection

vial of 1 Injection

₹3291

~~₹3641~~

Same composition

Coly Monas 4.5 Injection

vial of 1 Injection

Colistimethate Sodium (4.5Million IU)

by Glenmark Pharmaceuticals Ltd

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General Information

Contains

Colistimethate Sodium (4.5Million IU)

Marketer

Celon Laboratories Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Polyxx E 4.5M IU Injection is given under the supervision of a healthcare professional. You should not self-administer this medicine at home. The dose and duration will be decided by your doctor based on the severity and type of infection you have. Get the injection regularly for as long as your doctor has prescribed to get maximum benefits.

Common side effects of this medicine include gastrointestinal upset, slurred speech, dizziness, vertigo, fever, rash, and paresthesia. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or do not go away.

Before starting treatment with this medicine, you should tell the doctor if you are allergic to any antibiotic or have any liver or kidney problems. Pregnant or breastfeeding mothers should consult their doctor before using it. Your doctor may get regular blood tests done to monitor kidney function and the level of the medicine in your blood.

Uses of Polyxx E Injection

Severe bacterial infections

Benefits of Polyxx E Injection

Severe bacterial infections
Polyxx E 4.5M IU Injection is an antibiotic that works by killing bacteria which can cause serious infections. It is a versatile medicine used to treat many different types of bacterial infections. This medicine is usually given as an injection by a doctor or nurse and should not be self-administered at home.
This medicine usually makes you feel better very quickly but you should continue taking it as prescribed even when you feel better to make sure that all bacteria are killed and do not become resistant.

Side effects of Polyxx E Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Polyxx E

Slurred speech
Rash
Fever
Upset stomach
Gastrointestinal disturbance
Generalized itching
Red spots or bumps
Increased blood urea nitrogen
Increased creatinine level in blood
Decreased creatinine clearance
Respiratory distress
Apnea (absence of breathing)
Renal toxicity
Decreased urinary volume
Dizziness
Paresthesia (tingling or pricking sensation)
Vertigo

How to use Polyxx E Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Polyxx E Injection works

Polyxx E 4.5M IU Injection is an antibiotic. It kills bacteria by destroying the bacterial cell membrane.

All substitutes for Polyxx E 4.5M IU Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Polyxx E 4.5M IU Injection is an antibiotic that is usually only given in the hospital for serious infections.
It is given by injection or drip (infusion) into a vein usually over 30-60 minutes.
Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
Diarrhea may occur as a side effect. Inform your doctor if it doesn't stop or if you find blood in your stools.
Your doctor may get regular blood tests done to monitor the level of the medicine in your blood.

Safety advice

Alcohol

SAFE

Consuming alcohol with Polyxx E 4.5M IU Injection does not usually cause any harmful side effects.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Polyxx E 4.5M IU Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

SAFE IF PRESCRIBED

Polyxx E 4.5M IU Injection may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Driving

UNSAFE

Polyxx E 4.5M IU Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Polyxx E 4.5M IU Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Polyxx E 4.5M IU Injection in patients with liver disease.

Frequently asked questions

What should I tell my doctor before taking Polyxx E 4.5M IU Injection?

Before taking Polyxx E 4.5M IU Injection, you must tell your doctor if you have or ever had any problems related to your kidneys or lungs (such as asthma). Let your doctor know about all the other medicines you are taking because they may affect, or be affected by, this medicine.

How is Polyxx E 4.5M IU Injection administered?

Polyxx E 4.5M IU Injection should be administered under the supervision of a trained healthcare professional or a doctor only and should not be self-administered. The dose will depend on the condition you are being treated for and will be decided by your doctor. Follow your doctor’s instructions carefully to get maximum benefit from Polyxx E 4.5M IU Injection.

Who should not use Polyxx E 4.5M IU Injection?

Use of Polyxx E 4.5M IU Injection should be avoided in patients who are allergic to Polyxx E 4.5M IU Injection or any of its components. However, if you are not aware of any allergy or if you are using Polyxx E 4.5M IU Injection for the first time, consult your doctor.

Can I take Polyxx E 4.5M IU Injection in pregnancy?

Enough evidence is not available to provide clarity on the use of Polyxx E 4.5M IU Injection in pregnancy. However, if you are pregnant or planning to conceive, consult your doctor before taking Polyxx E 4.5M IU Injection. You may take it only if prescribed by your doctor.

Is Polyxx E 4.5M IU Injection safe?

Polyxx E 4.5M IU Injection is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.

What should I tell my doctor before taking Polyxx E 4.5M IU Injection?

How is Polyxx E 4.5M IU Injection administered?

Who should not use Polyxx E 4.5M IU Injection?

Can I take Polyxx E 4.5M IU Injection in pregnancy?

Is Polyxx E 4.5M IU Injection safe?

Fact Box

Chemical Class

Polypeptides

Habit Forming

Therapeutic Class

ANTI INFECTIVES

Action Class

Cell membrane active agent

Related lab tests

Complete Blood Count

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 324-25.
Colistimethate. Rochester, Michigan: JHP Pharmaceuticals, LLC.; 2013. [Accessed 11 Feb. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 28 Mar. 2019] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Celon Laboratories Ltd
Address: Plot No 264, Patrika Nagar Madhapur, Hitech City Hyderabad, Telangana India - 500081

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Polyxx E 4.5M IU Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Polyxx E Injection

Benefits of Polyxx E Injection

Side effects of Polyxx E Injection

How to use Polyxx E Injection

How Polyxx E Injection works

All substitutes for Polyxx E 4.5M IU Injection

Coly Monas 4.5 Injection

Xylistin 4.5MIU Injection

Koolistin 4.5Million IU Injection

Orcostin 4.5 Injection

Xylistin 4.5MIU Injection (PAP)

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What should I tell my doctor before taking Polyxx E 4.5M IU Injection?

How is Polyxx E 4.5M IU Injection administered?

Who should not use Polyxx E 4.5M IU Injection?

Can I take Polyxx E 4.5M IU Injection in pregnancy?

Is Polyxx E 4.5M IU Injection safe?

What should I tell my doctor before taking Polyxx E 4.5M IU Injection?

How is Polyxx E 4.5M IU Injection administered?

Who should not use Polyxx E 4.5M IU Injection?

Can I take Polyxx E 4.5M IU Injection in pregnancy?

Is Polyxx E 4.5M IU Injection safe?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Complete Blood Count

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests