Hi, there!
Login / Sign Up
Buy medicines
Buy health products
Book lab tests
Consult a doctor
1mg Care Plan
Cancer Care
Ayurveda
Partnerships
New
Hindi articles
Offers
All diseases
New
All medicines
Medicines by therapeutic class
Contact us
Need help?
Privacy policy
Return policy
Terms and conditions
Editorial policy
Get more features! Download the app now
Medicine Reminders
Monthly/weekly subscriptions
Health records and analysis
24*7 Emergency services
Download app on the App StoreDownload app on the Google play store
Choose city
Sign in to your account
or
By signing in you agree to our
Terms & conditions
 and 
Privacy policy
Sku Image
Sku Image
sold out tag
Genuine
Authenticity Assured
Prescription
required
Polmef 250mg/325mg Tablet is a combination of two medicines used in the treatment of fever. It is also useful for the treatment of mild to moderate pain of various conditions like headache, body ache, and toothache. It works by reducing chemical messengers that cause pain, inflammation, and fever.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 07 Aug 2026 | 01:07 AM (IST)
₹40.5 MRP ₹4510% off 
Gurgaon
 
 
0
footer-icon
sku_image
Polmef 250mg/325mg Tablet is currently sold out
Same composition alternative:
Mefnol Forte 250mg/325mg Tablet
₹32₹37.13
21% cheaper alternative available
Sold out
Polmef 250mg/325mg Tablet
Polmef 250mg/325mg Tablet
strip of 10 tablets
₹40.5
₹45
tag icon
Same composition
Mefnol Forte 250mg/325mg Tablet
Mefnol Forte 250mg/325mg Tablet
strip of 10 tablets
Mefenamic Acid (250mg) + Paracetamol (325mg)
by Knoll Pharmaceuticals Ltd
Get by 12am, Tomorrow
₹32
₹2.72 per tablet

₹27.2

order for
₹1200

Save more with additional offers

offer icon
Assured cashback up to ₹300*. T&C Apply*
Assured cashback up to ₹300*. T&C Apply*
chevron icon
offer icon
Get up to ₹75 cashback on a minimum order value (MOV) of ₹499 and above, valid once per customer.
Get up to ₹75 cashback on a minimum order value (MOV) of ₹499 and above, valid once per customer.
chevron icon
offer icon
Get upto Rs.500 Cashback on minimum transaction of Rs.999/- with Mobikwik Wallet.
Get upto Rs.500 Cashback on minimum transaction of Rs.999/- with Mobikwik Wallet.
chevron icon
offer icon
Assured cashback up to ₹300*. T&C Apply*
Assured cashback up to ₹300*. T&C Apply*
chevron icon
offer icon
Get up to ₹75 cashback on a minimum order value (MOV) of ₹499 and above, valid once per customer.
Get up to ₹75 cashback on a minimum order value (MOV) of ₹499 and above, valid once per customer.
chevron icon
offer icon
Get upto Rs.500 Cashback on minimum transaction of Rs.999/- with Mobikwik Wallet.
Get upto Rs.500 Cashback on minimum transaction of Rs.999/- with Mobikwik Wallet.
chevron icon
offer icon
Get upto Rs.150 Cashback on minimum transaction of Rs.599/- with Mobikwik UPI.
Get upto Rs.150 Cashback on minimum transaction of Rs.599/- with Mobikwik UPI.
chevron icon

General Information

Contains

Mefenamic Acid (250mg)+ Paracetamol (325mg)

Marketer

Humbing Ethicals

Storage

Store below 30°C
The content is shown in English
Polmef 250mg/325mg Tablet image
Polmef 250mg/325mg Tablet image

Product introduction

Polmef 250mg/325mg Tablet is to be taken with food. This will prevent you from getting an upset stomach. The dose will depend on what you are taking it for and how well it helps your symptoms. You should take it as advised by your doctor. Do not take more or use it for a longer duration than recommended by the doctor.

The most common side effects of this medicine include nausea, vomiting, diarrhea, indigestion, loss of appetite, and heartburn. If any of these side effects bother you or get worse, you should speak to your doctor. Your doctor may be able to suggest ways of preventing or reducing the side effects.

Before taking it, you should let your doctor know if you have a history of ulcers or bleeding in your stomach, high blood pressure, or any trouble with your heart, kidneys, or liver. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine.

Uses of Polmef Tablet

  • Pain relief : Polmef 250mg/325mg Tablet helps relieve pain in conditions such as headache, body ache, muscle pain, toothache, menstrual cramps, and minor injuries.
  • Treatment of Fever : Polmef 250mg/325mg Tablet helps reduce fever in conditions such as flu, viral infections, post-vaccination reactions, and other illnesses associated with fever.

Benefits of Polmef Tablet

Pain relief
Pain can occur due to inflammation or injury affecting different parts of the body. Polmef 250mg/325mg Tablet works by blocking chemical messengers responsible for pain and inflammation. This helps reduce discomfort in conditions such as headache, toothache, muscle pain, joint pain, and menstrual cramps. It improves daily functioning and provides effective short-term relief from pain.
Treatment of Fever
Fever is usually a sign of infection or inflammation in the body. Polmef 250mg/325mg Tablet helps reduce high temperature by blocking chemical messengers that trigger fever. This brings down body temperature and relieves associated symptoms such as body aches and discomfort.

Side effects of Polmef Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Polmef
  • Diarrhea
  • Nausea
  • Hypersensitivity
  • Skin rash

How to use Polmef Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Polmef 250mg/325mg Tablet should be taken with or after food.

How Polmef Tablet works

Polmef 250mg/325mg Tablet is a combination of two medicines: Mefenamic Acid and Paracetamol. It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling).

All substitutes for Polmef 250mg/325mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Meftal Forte Junior Tablet

by Blue Cross Laboratories Ltd
₹3.24/tablet
20% cheaper
<h3 class=bodySemiBold>Meftal Forte Junior Tablet</h3>

Tracemol MF 250mg/325mg Tablet

by Tansy Molequle
₹3.21/tablet
21% cheaper
<h3 class=bodySemiBold>Tracemol MF 250mg/325mg Tablet</h3>

Mefnol Forte 250mg/325mg Tablet

by Knoll Pharmaceuticals Ltd
₹3.2/tablet
21% cheaper
<h3 class=bodySemiBold>Mefnol Forte 250mg/325mg Tablet</h3>

Big PM 250mg/325mg Tablet

by Big Laboratories Pvt Ltd
₹5.74/tablet
42% costlier
<h3 class=bodySemiBold>Big PM 250mg/325mg Tablet</h3>

Mefmic P 250mg/325mg Tablet

by Vatican Life Sciences Pvt Ltd
₹3.08/tablet
24% cheaper
<h3 class=bodySemiBold>Mefmic P 250mg/325mg Tablet</h3>

Quick tips

  • Take Polmef 250mg/325mg Tablet with food to reduce the risk of stomach irritation.
  • Avoid taking Polmef 250mg/325mg Tablet with other medicines containing paracetamol or other NSAIDs unless advised by your doctor.
  • Polmef 250mg/325mg Tablet may cause dizziness or sleepiness, so avoid driving or operating machinery until you know how it affects you.
  • Stop taking Polmef 250mg/325mg Tablet and consult your doctor if you develop diarrhea while using this medicine.
  • Watch for warning signs such as severe stomach pain or black/tarry stools, and seek medical attention if they occur.
  • Avoid alcohol while taking Polmef 250mg/325mg Tablet as it may increase drowsiness and the risk of stomach or liver problems.
  • Stay well hydrated while taking Polmef 250mg/325mg Tablet, as dehydration may increase the risk of kidney-related side effects.
  • Inform your doctor if you develop rash, swelling, or other signs of allergy while taking Polmef 250mg/325mg Tablet.
  • Do not use Polmef 250mg/325mg Tablet for long periods without medical supervision.
  • Your doctor may monitor kidney function, liver function, and blood parameters if Polmef 250mg/325mg Tablet is used for long-term treatment.
  • Inform your doctor if you have a history of kidney disease, liver disease, or stomach ulcers before taking Polmef 250mg/325mg Tablet.
  • Do not increase the dose or frequency of Polmef 250mg/325mg Tablet without medical advice.
  • Consult your doctor if pain or fever persists or keeps recurring despite taking Polmef 250mg/325mg Tablet.

Safety advice

Alcohol

Alcohol

CAUTION
Alcohol should be used with caution while taking Polmef 250mg/325mg Tablet.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Polmef 250mg/325mg Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Polmef 250mg/325mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Polmef 250mg/325mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

CAUTION
Polmef 250mg/325mg Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Use of Polmef 250mg/325mg Tablet is not recommended in patients with severe kidney disease.
Liver

Liver

UNSAFE
Polmef 250mg/325mg Tablet is unsafe to use in patients with liver disease and should be avoided.
However, the use of Polmef 250mg/325mg Tablet is not recommended in patients with severe liver disease and active liver disease.

Frequently asked questions

Polmef 250mg/325mg Tablet may cause some common side effects such as nausea, stomach pain, heartburn, or diarrhea. Some people may also experience vomiting or dizziness. These effects often occur because the medicine can irritate the stomach lining. Taking Polmef 250mg/325mg Tablet with food or milk may help reduce stomach discomfort. In rare cases, it may cause serious problems such as stomach bleeding or kidney damage. Seek medical attention if you notice warning signs such as black stools, vomiting blood, or severe stomach pain.
Polmef 250mg/325mg Tablet is usually prescribed for short-term use to relieve pain. In many cases, it can be stopped once the pain improves. However, if your doctor has advised you to take it for a specific period, you should continue using it for the recommended duration. Always follow your doctor’s instructions before stopping any prescribed medicine.
Polmef 250mg/325mg Tablet should be avoided by people who are allergic to this medicine or to other similar pain relievers known as NSAIDs. It is also not recommended for individuals with stomach ulcers, active stomach bleeding, severe liver disease, or serious kidney problems. People who have a history of stomach irritation or bleeding should only take it if advised by a doctor. Always inform your doctor about your medical history and any other medicines you are taking before starting Polmef 250mg/325mg Tablet.
Yes, Polmef 250mg/325mg Tablet can usually be taken with vitamin B-complex supplements. While Polmef 250mg/325mg Tablet helps relieve pain, vitamin B-complex may help correct vitamin deficiencies that could contribute to certain types of pain, such as nerve-related discomfort. However, it is still best to consult your doctor before combining medications or supplements.
Polmef 250mg/325mg Tablet may affect the kidneys or liver if it is used for a long time or taken in higher-than-recommended doses. The medicine can reduce protective substances that help maintain kidney function, which may lead to kidney damage. Misuse or combining it with other medicines containing similar ingredients may also strain the liver. The risk is higher in people who already have kidney or liver disease. Always take Polmef 250mg/325mg Tablet only as prescribed and avoid unnecessary or prolonged use.
No, taking more than the recommended dose of Polmef 250mg/325mg Tablet can increase the risk of side effects such as nausea, vomiting, indigestion, heartburn, and diarrhea. Overuse may also harm the kidneys, especially with long-term use. If your pain is severe or not relieved by the prescribed dose, consult your doctor instead of increasing the dose on your own.
Polmef 250mg/325mg Tablet is a medicine used for short-term relief of pain and fever. It is commonly prescribed for menstrual cramps (period pain), dental pain, headaches, muscle or joint pain, and general body aches. It works by reducing certain substances in the body that cause pain, inflammation, and fever. While it helps relieve symptoms, it does not treat the underlying cause of the pain. Always take Polmef 250mg/325mg Tablet exactly as directed by your doctor and avoid long-term or unnecessary use.
Polmef 250mg/325mg Tablet is generally not recommended during pregnancy unless your doctor specifically advises it. Anti-inflammatory pain medicines can affect pregnancy and the baby, especially during the later stages. Mefenamic acid may affect the baby’s circulation and kidney function later in pregnancy and may also increase bleeding risk. If you are pregnant, think you may be pregnant, or are planning pregnancy, consult your doctor before taking Polmef 250mg/325mg Tablet.
It is best to avoid alcohol while taking Polmef 250mg/325mg Tablet. Alcohol can increase the risk of stomach irritation and bleeding, and it may also add stress to the liver when combined with certain pain medicines. If you drink alcohol regularly, discuss this with your doctor before taking Polmef 250mg/325mg Tablet.
The active ingredient in Polmef 250mg/325mg Tablet, mefenamic acid, is gradually cleared from the body, although the exact time can vary depending on factors such as age, liver and kidney function, and hydration. Even after the medicine starts leaving the body, stomach irritation or bleeding risk may persist for some time. If you are planning surgery or have kidney problems, inform your doctor that you have taken Polmef 250mg/325mg Tablet so they can advise you appropriately.

Fact Box

Habit Forming

No

Therapeutic Class

PAIN ANALGESICS

Related lab tests

Complete Blood Count

References

  1. FDA approved prescribing information. Mefenamic Acid; 2008 [revised Mar. 2007]. [Accessed 02 Apr. 2019] (online) Available from:
  2. ScienceDirect. Mefenamic Acid. [Accessed 02 Apr. 2019] (online) Available from:
  3. ScienceDirect. Paracetamol/Acetaminophen. [Accessed 23 Apr. 2019] (online) Available from:
  4. Paracetamol and Mefenamic acid. Centaur; [Accessed 16 Jan. 2026] (online). Available from:
Related products
Products related to Polmef 250mg/325mg Tablet
4.5Rating star
Volini Pain Relief Gel for Sprain, Muscle, Joint, Neck & Low Back Pain | Bone, Joint & Muscle Care
30 gm Gel
Get in 60 mins
₹136
₹160
15% off

₹122

order for
₹1200
4.5Rating star
Caripill Carica Papaya Leaf Extract Tablet
15 tablets
Get in 60 mins
₹547
₹637
14% off

₹492

order for
₹1200
4.5Rating star
Volini Pain Relief Gel for Sprain, Muscle, Joint, Neck & Low Back Pain | Bone, Joint & Muscle Care
50 gm Gel
Get in 60 mins
₹212
₹230
8% off

₹191

order for
₹1200
4.5Rating star
Volini Pain Relief Gel for Sprain, Muscle, Joint, Neck & Low Back Pain | Bone, Joint & Muscle Care
75 gm Gel
Get in 60 mins
₹250
₹272
8% off

₹225

order for
₹1200
4.5Rating star
Himalaya Rumalaya Liniment
60 ml Liniment
Get in 60 mins
₹156
₹168
7% off

₹140

order for
₹1200
4.3Rating star
Mienta Capsule
10 capsules
Get in 60 mins
₹200
₹205
2% off

₹180

order for
₹1200
4.5Rating star
Sensur Ayurvedic Fast Pain Relief Oil Roll On | For Headache, Cold, Nasal Congestion, Neck, Body & Joint Pain Relief
10 ml Oil
Get in 60 mins
₹135
₹144
6% off

₹122

order for
₹1200
4.5Rating star
Himalaya Rumalaya Pain Relief Gel| Quick relief from body pain| Ayurvedic | Gel
30 gm Gel
Get in 60 mins
₹129
₹140
8% off

₹116

order for
₹1200
4.3Rating star
Myolaxin Ointment with Menthol, Camphor & Eucalyptus Oil
15 gm Ointment
Get by Today
₹75

₹67.4

order for
₹1200
4.2Rating star
NuROKIND -Fast Sugar free Strip
1 Disintegrating Strip
Get in 60 mins
₹24.5
₹24.9
2% off

₹22.1

order for
₹1200
100% genuine products
100% genuine products
Safe & secure payments
Safe & secure payments
No contact delivery
No contact delivery
Fully sanitized facilities
Fully sanitized facilities
<h3 class=titleMediumExtraBold>Want to know more</h3>

Want to know more

We provide you with authentic, trustworthy and relevant information
<h3 class=titleMediumExtraBold>Have issue with the content</h3>

Have issue with the content

Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Humbing Ethicals
Address: a-1201, videocon tower, kandivilli (e), mumbai-101, maharashtra, india

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?
Homeright_chevronPain Analgesicsright_chevronAnti Rheumatics Non Steroidal Systemicright_chevron
Polmef 250mg/325mg Tablet
close sheet
brand logo
Making healthcare understandable, accessible & affordable
India’s largest healthcare platform
260m+
Visitors
31m+
Orders Delivered
1800+
Cities
India's only LegitScript and ISO/ IEC 27001:2022 certified online healthcare platform
URS

Access medical and health information

Tata 1mg provides you with medical information which is curated, written and verified by experts, accurate and trustworthy. Our experts create high-quality content about medicines, diseases, lab investigations, Over-The-Counter (OTC) health products, Ayurvedic herbs/ingredients, and alternative remedies.

Order medicines online

Get free medicine home delivery in over 1800 cities across India. You can also order Ayurvedic, Homeopathic and other Over-The-Counter (OTC) health products. Your safety is our top priority. All products displayed on Tata 1mg are procured from verified and licensed pharmacies.

Book lab tests

Book any lab tests and preventive health packages from certified labs and get tested from the comfort of your home. Enjoy free home sample collection, view reports online and consult a doctor online for free.

Consult a doctor online

Got a health query? Consult doctors online from the comfort of your home for free. Chat privately with our registered medical specialists to connect directly with verified doctors. Your privacy is guaranteed.
facebookinstagramtwitteryoutubelinkedinmedium
Our payment partners
visamastercardamerican expressrupaypaytmamazon paygoogle paymobiwikfreechargephone paysimpleairtel
TATA
© 2026 Tata 1mg. All rights reserved. All medicines are dispensed in compliance with the Drugs and Cosmetics Act, 1940 and Drugs and Cosmetics Rules, 1945. We do not process requests for Schedule X and habit forming drugs.