
Phenergan Plus Syrup
Written By Dr. Lipika Khurana, PGDHHM, BDS
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS
Last updated on 17 Dec 2025 | 04:35 PM (IST)
Phenergan Plus Syrup is commonly prescribed in children to treat fever, body ache as well as allergic symptoms associated with common cold like runny nose, cough, sneezing, and watery eyes. Also, it is one of the commonly used medicines in chickenpox for symptomatic relief.
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General Information
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Your child’s medicine at a glance
Give Phenergan Plus Syrup to your child by mouth with or without food, preferably at a fixed time. Children often have a sensitive stomach and complain of stomach upset while taking medicines. Prefer giving this medicine with food if this happens. Always remember that the dosing schedule provided by your child’s doctor depends on the type of symptoms your child has, so make sure to follow the prescribed dose, time, and way strictly. If your child vomits within 30 minutes of taking this medicine, give the same dose again.
Some of the minor and temporary side effects that your child may experience while taking this medicine include vomiting, diarrhea, nausea, dizziness, sleepiness, and skin rash. Usually, these episodes subside once your child’s body adapts to the medicine. In case these side effects persist or become bothersome for your child, consult your child’s doctor without any delay.
Share your child’s complete medical history with your child’s doctor, including any ongoing medicine regime or history of any allergy, heart problem, blood disorder, birth defects, airway obstruction, lung anomaly, skin disorder, liver impairment, and kidney malfunction. This information is critical for dose alterations and for planning your child’s overall treatment.
Some of the minor and temporary side effects that your child may experience while taking this medicine include vomiting, diarrhea, nausea, dizziness, sleepiness, and skin rash. Usually, these episodes subside once your child’s body adapts to the medicine. In case these side effects persist or become bothersome for your child, consult your child’s doctor without any delay.
Share your child’s complete medical history with your child’s doctor, including any ongoing medicine regime or history of any allergy, heart problem, blood disorder, birth defects, airway obstruction, lung anomaly, skin disorder, liver impairment, and kidney malfunction. This information is critical for dose alterations and for planning your child’s overall treatment.
Uses of Phenergan Plus Syrup in children
Benefits of Phenergan Plus Syrup for your child
Treatment of Fever
Phenergan Plus Syrup helps reduce high body temperature and relieve headache, body ache, and malaise. It works by blocking the pain and fever pathways in the brain responsible for the rise in body temperature.
Phenergan Plus Syrup helps reduce high body temperature and relieve headache, body ache, and malaise. It works by blocking the pain and fever pathways in the brain responsible for the rise in body temperature.
Treatment of Common cold
Phenergan Plus Syrup is a combination medicine that effectively relieves symptoms of the common cold, such as a blocked nose, runny nose, watery eyes, sneezing, and congestion or stuffiness. It helps loosen thick mucus, making it easier to cough out. It also shrinks the blood vessels and provides rapid relief that lasts for several hours. These actions make breathing easier.
Phenergan Plus Syrup is safe and effective. It usually starts to work within a few minutes, and the effects can last up to several hours. Take it as prescribed by your doctor, and do not stop using it unless you are advised otherwise.
Phenergan Plus Syrup is a combination medicine that effectively relieves symptoms of the common cold, such as a blocked nose, runny nose, watery eyes, sneezing, and congestion or stuffiness. It helps loosen thick mucus, making it easier to cough out. It also shrinks the blood vessels and provides rapid relief that lasts for several hours. These actions make breathing easier.
Phenergan Plus Syrup is safe and effective. It usually starts to work within a few minutes, and the effects can last up to several hours. Take it as prescribed by your doctor, and do not stop using it unless you are advised otherwise.
Side effects of Phenergan Plus Syrup in children
Phenergan Plus Syrup does not pose serious side effects and is well-tolerated by children. In case the side effects do occur, they’re likely to subside once the body adapts to the medicine. Consult your child’s doctor if these side effects persist or bother your child. The most common side effects include-
Common side effects of Phenergan Plus
- Vomiting
- Nausea
- Diarrhea
- Rash
- Dizziness
How can I give Phenergan Plus Syrup to my child?
Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Phenergan Plus Syrup may be taken with or without food.
How Phenergan Plus Syrup works
Phenergan Plus Syrup contains two active ingredients: paracetamol, and promethazine. These ingredients together relieve common cold symptoms. Promethazine is an antiallergic that relieves allergy symptoms like runny nose, watery eyes, and sneezing. Paracetamol is an analgesic (pain reliever) and antipyretic (fever reducer). It blocks the release of certain chemical messengers in the brain that are responsible for pain and fever.
Quick tips
- Phenergan Plus Syrup may make your child feel sleepy. Ensure your child takes extra care when taking part in physical activities.
- Never combine Phenergan Plus Syrup with other cold and flu medicines as that may lead to side effects.
- Stop Phenergan Plus Syrup and immediately report to the doctor if your child develops an itchy rash, facial swelling, or breathing difficulties.
- Practice self-care tips:
- Keep the surroundings and surfaces neat and clean to avoid exposure to allergens
- Make sure your child maintains proper hygiene and sanitation to avoid infection
- Ensure your child takes enough rest to expedite recovery.
Safety advice

Kidney
SAFE IF PRESCRIBED
Phenergan Plus Syrup is safe to use in patients with kidney disease. No dose adjustment is recommended.
However, caution is advised in patients with severe kidney disease as it may cause excessive sleepiness in them.
However, caution is advised in patients with severe kidney disease as it may cause excessive sleepiness in them.

Liver
CAUTION
Phenergan Plus Syrup should be used with caution in patients with liver disease. Dose adjustment may be needed.
The use of Phenergan Plus Syrup is not recommended in children with severe liver disease and active liver disease.
The use of Phenergan Plus Syrup is not recommended in children with severe liver disease and active liver disease.
Frequently asked questions
Phenergan Plus Syrup should not be used in children who are less than 2 years of age because it has the potential of causing fatal respiratory depression.
Prolonged or excess intake of Phenergan Plus Syrup can put your child at risk of developing serious side effects like bradycardia, decreased blood pressure, confusion, delirium, disorientation, dizziness, drowsiness, and hallucinations. Always stick to the prescribed dose. To pour out the right dose, use the calibrated cup provided with the medicine by the manufacturer. Do not use a kitchen teaspoon as it will not give the correct estimate.
Phenergan Plus Syrup usually starts working within 30 to 60 minutes of intake and shows its peak effect within 3 to 4 hours. Your child may start to feel better after a few doses. In case the pain or fever persists longer, consult your child’s doctor immediately.
Keep Phenergan Plus Syrup out of the reach and sight of children to avoid any accidental intake. Also, it should be stored at room temperature, in a dry place, away from direct heat and light.
Phenergan Plus Syrup may cause mild drowsiness, making your child feel sleepy. So, be cautious and never give this medicine if your child is suffering from a sleep disorder as this medicine can mask the symptoms of underlying sleep disorders like insomnia. It is always best to consult your child’s doctor before giving this medicine to your child.
It is advised to use Phenergan Plus Syrup with caution if the child has malnutrition, G6PD deficiency, liver disease, or any medicinal allergy. So, do not hesitate to share your child’s complete medical history with the doctor as that will help the doctor decide whether the medicine is safe for your child or not.
Do not delay calling your child’s doctor if your child starts to show side effects like irregular heartbeat, complaints of urinary retention, vision problem, muscle spasm, irregular bodily movements, and sudden weakness.
Fact Box
Habit Forming
No
Therapeutic Class
RESPIRATORY
Related lab tests
References
- Paracetamol, promethazine hydrochloride, dextromethorphan hydrobromide [Patient Information Leaflet]. Tipperary, Ireland: Pinewood Laboratories Ltd.; 2020. [Accessed 20 Jan. 2021] (online) Available from:
- Promethazine HCl. Philadelphia, PA: Wyeth Pharmaceuticals Inc.; 2004. [Accessed 20 Jan. 2021] (online) Available from:
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