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Penflu 40 mg Injection is a combination of two medicines used in the treatment of depression. This medicine helps by increasing the level of chemical messengers in the brain that have a calming effect on the brain and relax the nerves, thus treating your depression.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 31 Mar 2026 | 02:28 PM (IST)
₹290 MRP ₹317.819% off 
As per Ministry of Health and Family Welfare
 
 
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Penflu 40 mg Injection image
Penflu 40 mg Injection image

Product introduction

Penflu 40 mg Injection is administered as an injection under the supervision of medical supervision. It is given in cases where oral administration is not possible. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember. It is important that this medication is not stopped suddenly without talking to your doctor as it may worsen your symptoms.

Some common side effects of this medicine include dry mouth, constipation, urinary retention, blurred vision, increased heart rate, muscle rigidity, restlessness, and tremor. Initially, this medicine may cause a sudden drop in blood pressure when you change positions, rise slowly if you have been sitting or lying down. It may also cause dizziness and sleepiness, do not drive or do anything that requires mental focus until you know how this medicine affects you.

Before taking it, inform your doctor if you are suffering from thyroid or kidney disease, epilepsy, Parkinson’s disease, glaucoma, or any heart disease. You should not take this medicine if you are under the influence of alcohol or any sleep-inducing, cough, and/ or allergy medication. This medicine can also lead to weight gain, eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly.

Uses of Penflu Injection

Benefits of Penflu Injection

Treatment of Depression
Penflu 40 mg Injection is a combination medicine that helps in maintaining the balance of certain chemicals in the brain that affect mood and behavior. This improves your mood, relieves anxiety, tension, helps you sleep better and increases your energy levels. Penflu 40 mg Injection prevents extreme changes in mood and helps you feel less agitated. You may experience fewer episodes of depression and low mood.
It can take several weeks for this medicine to work and you may still feel low during this time. It is likely that you will take this medicine for at least six months but possibly much longer. It needs to be taken regularly to work effectively. Do not stop taking it unless your doctor tells you to.

Side effects of Penflu Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Penflu
  • Constipation
  • Urinary retention
  • Weight gain
  • Sleepiness
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Increased heart rate
  • Increased prolactin level in blood
  • Blurred vision
  • Dryness in mouth
  • Muscle stiffness
  • Tremors
  • Restlessness

How to use Penflu Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Penflu Injection works

Penflu 40 mg Injection is a combination of two medicines: Flupenthixol and Melitracen. Flupenthixol is a typical antipsychotic. It works by blocking the action of dopamine, a chemical messenger in the brain that affects thoughts and mood. Melitracen is a tricyclic antidepressant which increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.

Quick tips

  • Penflu 40 mg Injection helps treat anxiety and depression.
  • Use caution while driving or doing anything that requires concentration as Penflu 40 mg Injection can cause dizziness and sleepiness.
  • Avoid drinking alcohol while taking this medicine because it can make drowsiness worse.
  • It can cause changes in your blood sugar levels. Monitor your blood sugar regularly.
  • Inform your doctor if you have liver disease, thyroid disorder, severe heart disease, or a urinary disorder.
  • Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
  • Let your doctor know you are taking Penflu 40 mg Injection before undergoing any surgical procedure.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Penflu 40 mg Injection
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Penflu 40 mg Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Penflu 40 mg Injection during breastfeeding is not available. Please consult your doctor.
Driving

Driving

UNSAFE
Penflu 40 mg Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of Penflu 40 mg Injection in patients with kidney disease. Please consult your doctor.
Liver

Liver

CAUTION
Penflu 40 mg Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Frequently asked questions

Penflu 40 mg Injection is a combination of two medicines: Flupenthixol and Melitracen. This medicine is used to treat various forms of mood disorders. It works by balancing the amount of certain natural substances in the brain that are responsible for mood swings.

Fact Box

Habit Forming

No

Therapeutic Class

NEURO CNS
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Mova Pharmaceutical Pvt Ltd
Address: F-11, 2nd Main Road, Anna Nagar East, Chennai - 600 102.

Vendor Details

Country of origin: India
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