Overview
Uses and benefits
Side effects
How to use
How drug works
Safety advice
Missed dose
All substitutes
Quick tips
Fact box
User feedback
FAQs

Author Details

Written By

Dr. Swati Mishra

BDS

Reviewed By

Dr. Sachin Gupta

MD Pharmacology, MBBS

Last updated

22 May 2026 | 06:22 PM (IST)

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Orni-O Tablet

Prescription Required

Marketer

Zydus Cadila

SALT COMPOSITION

Ofloxacin (200mg) + Ornidazole (500mg)

Storage

Store below 25°C

32% cheaper alternative available with same salt composition

Click here to view all substitutes

Product introduction

Orni-O Tablet is a combination of two antibiotics. It is used in the treatment of bacterial and parasitic infections. It effectively treats a wide range of bacterial infections that may occur in the teeth, lungs, gastrointestinal tract, urinary tract, and genital tract.

Orni-O Tablet is best taken with food. Take it at a fixed time to ensure better efficacy. Do not take more than the recommended dose, as it may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The treatment must be completed even if you feel better to ensure a complete recovery.

This medicine may lead to some side effects such as nausea, vomiting, dizziness, and headache. To overcome any such side effects, it is advised to eat a healthy, balanced diet and drink plenty of fluids. If any of the side effects get aggravated, consult your doctor immediately. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.

Before taking this medicine, tell your doctor if you have any liver or kidney problems. Also, inform your doctor about all other medicines you are taking for any health condition. Pregnant or breastfeeding women should consult their doctor before using this medicine. Avoid drinking alcohol during treatment, as it may increase dizziness. This medicine usually does not affect the ability to drive, but do not drive or operate machinery if it makes you sleepy or dizzy. If you are allergic to this medicine, avoid using it. Adequate rest during the course of treatment may help the medicine work more effectively.

Uses of Orni-O Tablet

Treatment of Bacterial & parasitic infections

Benefits of Orni-O Tablet

In Treatment of Bacterial & parasitic infections

Orni-O Tablet is a medicine used to treat infections caused by bacteria and parasites. It works by killing harmful microorganisms and stopping their growth, helping the body clear the infection. This helps relieve symptoms such as diarrhea, abdominal pain, cramps, and discomfort. As the infection resolves, it supports recovery and helps restore normal digestive function. Complete the full course as prescribed to help prevent recurrence and to reduce the risk of drug resistance.

Side effects of Orni-O Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Orni-O

Dizziness
Headache
Insomnia (difficulty in sleeping)
Vomiting
Itching
Vaginal inflammation
Diarrhea
Nausea

How to use Orni-O Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Orni-O Tablet should be taken with or after food.

How Orni-O Tablet works

Orni-O Tablet is a combination of two antibiotics: Ofloxacin and Ornidazole. Ofloxacin works by preventing the bacterial cells from dividing and repairing, thereby killing the bacteria. Ornidazole kills parasites and anaerobic bacteria that cause infections by damaging their DNA. Together, they treat your infection effectively.

Safety advice

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. Orni-O Tablet may cause excessive drowsiness when taken with alcohol.

Pregnancy

UNSAFE

Orni-O Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

UNSAFE

Orni-O Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Orni-O Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Orni-O Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Orni-O Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

What if you forget to take Orni-O Tablet?

If you miss a dose of Orni-O Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Orni-O Tablet

₹13.3/Tablet

Ofron-OZ Tablet

Leeford Healthcare Ltd

₹5.14/tablet

61% cheaper

Oflotas-OZ Tablet

Intas Pharmaceuticals Ltd

₹9/tablet

32% cheaper

Olox-OZ Tablet

Cipla Ltd

₹11/tablet

17% cheaper

O2 Tablet

Medley Pharmaceuticals

₹17.8/tablet

34% costlier

Oflox OZ Tablet

Cipla Ltd

₹18.3/tablet

38% costlier

View all substitutes

Quick tips

Complete the full course of Orni-O Tablet exactly as advised, even if you start feeling better.
Take Orni-O Tablet with water and maintain adequate hydration, especially if diarrhea is present.
Avoid alcohol while taking Orni-O Tablet and for some time after completing the course, as it may cause severe reactions and worsen side effects.
Avoid taking antacids or mineral supplements close to the dose of Orni-O Tablet unless advised by your doctor, as they may reduce its absorption.
Seek medical advice if you develop severe diarrhea, bloody stools, or high fever.
Stop taking Orni-O Tablet and seek medical help if you develop rash, swelling, breathing difficulty, or signs of allergic reaction.
Inform your doctor if you have kidney disease, seizures, or heart rhythm problems before taking Orni-O Tablet.
Report symptoms such as tendon pain, numbness, tingling, palpitations, or severe dizziness promptly.
Consult your doctor if symptoms do not improve within 2–3 days of starting Orni-O Tablet.
Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding before taking Orni-O Tablet.

Fact Box

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

User feedback

Patients taking Orni-O Tablet

Twice A Day

92%

Once A Day

Thrice A Day

What are you using Orni-O Tablet for?

Bacterial inf*

50%

Others

39%

Diarrhea

11%

*Bacterial infections

How much was the improvement?

Average

52%

Excellent

36%

Poor

12%

What were the side-effects while using Orni-O Tablet?

Headache

21%

No Side Effec*

21%

Nausea

11%

Loss of appet*

11%

Allergic reac*

*No Side Effect, Loss of appetite, Allergic reaction

How do you take Orni-O Tablet?

With food

92%

With or witho*

*With or without food

Please rate Orni-O Tablet on price

Expensive

47%

Average

44%

Not Expensive

FAQs

What is Orni-O Tablet used for and how does it work?

Orni-O Tablet is an antibiotic combination containing ofloxacin and ornidazole, used to treat certain bacterial and parasitic infections. It may be prescribed for gastrointestinal infections such as infectious diarrhea or dysentery, and some abdominal or genital infections. It works by killing harmful microorganisms and stopping their growth so the body can clear the infection more effectively.

What are the common side effects of Orni-O Tablet?

Orni-O Tablet is generally safe when taken as prescribed, but some people may experience nausea, vomiting, stomach pain, dizziness, headache, heartburn, or dryness of the mouth. These effects are usually mild and improve as the body adjusts to the medicine. Stop using it and contact your doctor if you develop severe rash, breathing difficulty, persistent vomiting, or unusual weakness.

Are there any contraindications for using Orni-O Tablet?

Orni-O Tablet should not be used in people who are allergic to ofloxacin, ornidazole, or other medicines from the quinolone or nitroimidazole groups of antibiotics. Always inform your doctor about any past drug allergies before starting treatment.

How many doses of Orni-O Tablet can be taken in a day?

Orni-O Tablet should be taken only in the dose prescribed by your doctor. Taking more than recommended may increase the risk of side effects. Always complete the full course even if you feel better earlier.

What should I do if I do not feel better after taking Orni-O Tablet?

Inform your doctor if you do not feel better after completing the full course of Orni-O Tablet. You should also seek medical advice if your symptoms worsen during treatment.

Can I stop taking Orni-O Tablet when I feel better?

No, you should not stop Orni-O Tablet early even if you feel better. Stopping treatment too soon may allow the infection to return and may contribute to antibiotic resistance.

What should I do if I miss a dose of Orni-O Tablet?

If you miss a dose of Orni-O Tablet, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular schedule. Do not take an extra dose to make up for the missed one.

Can I drink alcohol while taking Orni-O Tablet?

It is best to avoid alcohol while using Orni-O Tablet because alcohol may increase side effects such as dizziness, sleepiness, or stomach discomfort.

Is Orni-O Tablet suitable for everyone? Who should avoid it?

Orni-O Tablet should be used during pregnancy or breastfeeding only if prescribed by a doctor. People with kidney or liver problems should also use it cautiously and under medical supervision.

How long does Orni-O Tablet take to work?

Orni-O Tablet usually begins working soon after it is taken, but improvement in symptoms may take a few days depending on the infection and your overall health. Always follow the full course recommended by your doctor.

What food or medicines should I avoid while taking Orni-O Tablet?

Always inform your doctor about other medicines or supplements you are taking before using Orni-O Tablet. Some medicines may interact with antibiotics and affect how they work, so medical advice is important before combining treatments.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Ornidazole & Ofloxacin [EMC SmPC]. Bangalore, India: MICRO LABS LIMITED; 2021. [Accessed 14 Aug. 2024] (online) Available from:
Ornidazole and Ofloxacin [Product Information]. Mumbai, Maharashtra: Ochoa Laboratories; [Accessed 11 Nov. 2025] (online). Available from:

Marketer details

Name: Zydus Cadila

Address: Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.

Country of origin: India
Expires on or after: February, 2027

A licensed vendor partner from your nearest location will deliver Orni-O Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

MRP₹149.74 11% OFF

₹133

Inclusive of all taxes

10.0 tablets in 1 strip

The price displayed is the MRP (inclusive of applicable taxes). Any additional fee (such as shipping fee, handling and/or platform fee etc.) will be clearly disclosed before you complete your purchase.