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Orio Plus Tablet is a combination of two antibiotics. It is used in the treatment of bacterial and parasitic infections. It effectively treats a wide range of bacterial infections that may occur in the teeth, lungs, gastrointestinal tract, urinary and genital tract.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 14 Mar 2026 | 12:10 AM (IST)
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Orio Plus Tablet
Orio Plus Tablet
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₹6.84 per tablet
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₹68.4

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by Samson Laboratories Pvt Ltd
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General Information

Contains

Ofloxacin (200mg)+ Ornidazole (500mg)

Marketer

Samson Laboratories Pvt Ltd

Storage

Store below 30°C
The content is shown in English
Orio Plus Tablet image
Orio Plus Tablet image

Product introduction

Orio Plus Tablet is best taken with food. Take it at a fixed time to ensure better efficacy. Do not take more than the recommended dose, as it may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The treatment must be completed even if you feel better to ensure a complete recovery.


This medicine may lead to some side effects such as nausea, vomiting, dizziness, and headache. To overcome any such side effects, it is advised to eat a healthy, balanced diet and drink plenty of fluids. If any of the side effects get aggravated, consult your doctor immediately. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.


Before taking this medicine, you should tell your doctor if you have any problems with your liver or kidneys. Also, tell your doctor if you are on any medication for any health condition. Pregnant or breastfeeding women should also consult with their doctors before taking it. Avoid drinking alcohol as it can cause excessive dizziness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. If you have known allergies to the medicine, refrain from using this medicine. It is advised to take proper rest during the course of treatment for the medicine to work effectively.

Uses of Orio Plus Tablet

  • Treatment of Bacterial & parasitic infections

Benefits of Orio Plus Tablet

Treatment of Bacterial & parasitic infections
Orio Plus Tablet is a combination medicine which can be used to treat infections caused by bacteria and parasites. It works by killing and stopping the growth of the bacteria and parasites causing the infection. This medicine usually makes you feel better quite quickly. However, you should continue taking it as long as it is prescribed, even if you feel better, to make sure that all bacteria and parasites are killed and do not become resistant.

Side effects of Orio Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Orio Plus
  • Dizziness
  • Headache
  • Insomnia (difficulty in sleeping)
  • Nausea
  • Vomiting
  • Itching
  • Vaginal inflammation
  • Diarrhea

How to use Orio Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Orio Plus Tablet should be taken with or after food.

How Orio Plus Tablet works

Orio Plus Tablet is a combination of two antibiotics: Ofloxacin and Ornidazole. Ofloxacin works by preventing the bacterial cells from dividing and repairing, thereby killing the bacteria. Ornidazole kills parasites and anaerobic bacteria that cause infections by damaging their DNA. Together, they treat your infection effectively.

All substitutes for Orio Plus Tablet

For information purposes only. Consult a doctor before taking any medicine.

Ofron-OZ Tablet

by Leeford Healthcare Ltd
₹5.29/tablet
34% cheaper
<h3 class=bodySemiBold>Ofron-OZ Tablet</h3>

Oflotas-OZ Tablet

by Intas Pharmaceuticals Ltd
₹9.28/tablet
15% costlier
<h3 class=bodySemiBold>Oflotas-OZ Tablet</h3>

Olox-OZ Tablet

by Cipla Ltd
₹10.3/tablet
28% costlier
<h3 class=bodySemiBold>Olox-OZ Tablet</h3>

O2 Tablet

by Medley Pharmaceuticals
₹19.7/tablet
145% costlier
<h3 class=bodySemiBold>O2 Tablet</h3>

Oflox OZ Tablet

by Cipla Ltd
₹18.7/tablet
132% costlier
<h3 class=bodySemiBold>Oflox OZ Tablet</h3>

Quick tips

  • It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
  • Avoid consuming alcohol when taking Orio Plus Tablet as it may irritate your stomach and also cause excessive drowsiness.
  • Inform your doctor if you are pregnant or planning to conceive or breastfeeding.

Safety advice

Alcohol

Alcohol

UNSAFE
Do not drink alcohol while you are taking this medicine. Orio Plus Tablet may cause excessive drowsiness when taken with alcohol.
Pregnancy

Pregnancy

UNSAFE
Orio Plus Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

UNSAFE
Orio Plus Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving

Driving

UNSAFE
Orio Plus Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Orio Plus Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Orio Plus Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Frequently asked questions

Orio Plus Tablet is a combination of two medicines: Ofloxacin and Ornidazole. They work by killing the harmful micro-organisms that can cause infection. Together they help to treat your infection effectively.
Orio Plus Tablet is safe for most of the patients. In some patients, it may cause common side effects like nausea, vomiting, stomach pain, dizziness, headache, dryness in the mouth, heartburn and other uncommon or rare side effects. Consult your doctor if you experience any persistent problem while taking this medication.
The use of Orio Plus Tablet is considered to be harmful for patients with known allergy to ofloxacin or to ornidazole or any medicine which belongs to the quinolone or nitroimidazole group of antimicrobial agents.
No, taking a higher than the recommended dose of Orio Plus Tablet can increase the risks of side effects. If you are experiencing increased severity of your symptoms which are not relieved by the recommended doses, please consult your doctor for re-evaluation.
Inform your doctor if you don't feel better after finishing the full course of treatment. Also, inform him if your symptoms are getting worse while using this medicine.
No, do not stop taking Orio Plus Tablet and complete the full course of treatment even if you are feeling better. Your symptoms may improve before the infection is completely cured.
Take Orio Plus Tablet as soon as you remember it. However, do not take it if it's almost time for your next dose. Also, do not take an extra dose to make up for your missed dose.
You should avoid alcohol since it may add to the dizziness and sleepiness caused by Orio Plus Tablet. Consult with your doctor, if you are not sure about the effects of the medicine.
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Fact Box

Habit Forming

No

Therapeutic Class

GASTRO INTESTINAL

References

  1. Ofloxacin. Raritan, New Jersey: Ortho-McNeil-Janssen Pharmaceuticals, Inc.; 2008. [Accessed 01 Apr. 2019] (online) Available from:
  2. ScienceDirect. Ornidazole. [Accessed 30 Mar. 2019] (online) Available from:
  3. Ofloxacin. Potters Bar Hertfordshire: Generics [UK] Limited; 2002 [revised Mar. 2016]. [Accessed 01 Apr. 2019] (online) Available from:
  4. Ornidazole. Auckland, New Zealand: Teva Pharma (New Zealand) Limited; 2017. [Accessed 30 Mar. 2019] (online) Available from:
  5. Ornidazole & Ofloxacin [EMC SmPC]. Bangalore, India: MICRO LABS LIMITED; 2021. [Accessed 14 Aug. 2024] (online) Available from:
  6. Ornidazole and Ofloxacin. Mumbai, Maharashtra: Ochoa Laboratories; [Accessed 11 Nov. 2025] (online). Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Samson Laboratories Pvt Ltd
Address: SCO 40, Swastik Vihar, MDC, Sector-5, Panchkula-134 109 INDIA

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Orio Plus Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's â„ž and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

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Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945
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