Onyx Plus Tablet

Fluoxetine (20mg)+ Olanzapine (5mg)

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Onyx Plus Tablet is a prescription medicine used in the treatment of depression associated with bipolar disorder. It works by increasing the level of chemical messengers in the brain, which improves mood and physical symptoms of depression.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 25 Nov 2025 | 03:07 PM (IST)

₹45.8 MRP ₹49.698% off

Gurgaon

Onyx Plus Tablet is currently sold out

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Oleanz Plus Tablet

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Onyx Plus Tablet

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Same composition

Oleanz Plus Tablet

strip of 10 tablets

Fluoxetine (20mg) + Olanzapine (5mg)

by Sun Pharmaceutical Industries Ltd

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General Information

Contains

Fluoxetine (20mg)+ Olanzapine (5mg)

Marketer

Biologic Psychotropics India Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Onyx Plus Tablet may be taken with or without food. Take it at the same time each day, as this helps maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and do not miss a dose. This medication must not be stopped suddenly without talking to your doctor, as it may worsen your symptoms.

Some common side effects of this medicine include dryness in the mouth, weight gain, and disturbance in attention. It may also cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how this medicine affects you. However, these symptoms are temporary and usually resolve on their own. Please consult your doctor if these do not subside or bother you.

Before taking Onyx Plus Tablet, inform your doctor if you are suffering from thyroid or kidney disease, epilepsy, Parkinson’s disease, glaucoma, or any heart disease. You should not take this medicine if you are under the influence of alcohol or any sleep-inducing, coughing, or allergy medication. You should avoid alcohol while taking Onyx Plus Tablet, as it may worsen certain side effects.

Onyx Plus Tablet can also lead to weight gain, eat a healthy, balanced diet, avoid snacking with high-calorie food, and exercise regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.

Uses of Onyx Plus Tablet

Depression associated with Bipolar disorder
Bipolar depression

Benefits of Onyx Plus Tablet

Depression associated with Bipolar disorder
Onyx Plus Tablet is used in the treatment for depression associated with bipolar disorder. It helps stabilize mood and improve overall well-being. It works by relieving persistent feelings of sadness and reducing emotional ups and downs. Onyx Plus Tablet helps in improving focus, sleep, and overall mental health. It offers a reliable option for those seeking better management of bipolar depression, allowing them to maintain a more balanced and fulfilling life.

Side effects of Onyx Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Onyx Plus

Weight gain
Dryness in mouth
Edema (swelling)
Difficulty in paying attention
Fatigue
Increased appetite
Sedation
Sleepiness
Blurred vision

How to use Onyx Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Onyx Plus Tablet may be taken with or without food.

How Onyx Plus Tablet works

Onyx Plus Tablet is a combination of two medicines: Fluoxetine and Olanzapine. They work by increasing the activity of certain chemicals called serotonin, norepinephrine, and dopamine in the brain. These chemicals help relieve the symptoms of depression associated with bipolar depression.

All substitutes for Onyx Plus Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Take it in the evening, as Onyx Plus Tablet can make you feel sleepy.
It may take 4 to 6 weeks to experience the full benefits of the medication.
Do not drive or do anything requiring concentration until you know how it affects you.
It may cause an increase in weight, blood sugar, cholesterol, and triglycerides (fat). Eat healthy and exercise regularly.
Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Onyx Plus Tablet

Pregnancy

CONSULT YOUR DOCTOR

The safety of Onyx Plus Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Onyx Plus Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Onyx Plus Tablet may cause side effects that could affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Onyx Plus Tablet is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.

Liver

CAUTION

Onyx Plus Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Frequently asked questions

What is Onyx Plus Tablet used for?

Onyx Plus Tablet is used to treat depression in bipolar disorder (bipolar depression) and treatment-resistant depression (when other antidepressants haven’t worked). It combines an antidepressant (fluoxetine) and an antipsychotic (olanzapine) to help improve mood, sleep, appetite, and energy.

Can Onyx Plus Tablet be used in children or elderly patients?

Onyx Plus Tablet is not approved for children under 10 years of age and should be avoided in elderly people with dementia, as it increases the risk of death and stroke in such patients.

What are the serious side effects of Onyx Plus Tablet I should know about?

During Onyx Plus Tablet therapy, some serious side effects include suicidal thoughts (especially in younger people), severe allergic reactions (rash, swelling), high blood sugar or diabetes, unusual body movements (tardive dyskinesia), serotonin syndrome (confusion, sweating, fast heart rate), and seizures or fainting. Call your doctor right away if you notice any of these symptoms.

Does Onyx Plus Tablet cause weight gain?

Yes. Weight gain and increased appetite are common side effects of Onyx Plus Tablet. Regular weight checks are recommended during treatment.

Can I stop taking Onyx Plus Tablet suddenly?

You should never stop taking Onyx Plus Tablet suddenly. Doing so can lead to withdrawal symptoms like dizziness, mood swings, and flu-like feelings. Always talk to your doctor before stopping.

What should I avoid while taking Onyx Plus Tablet?

You should avoid consuming alcohol (increases drowsiness and blood pressure drops), operating vehicles or machinery if feeling sleepy, and other serotonin-boosting drugs unless approved by your doctor. Tell your doctor about all medications and supplements you take to avoid dangerous interactions.

Can Onyx Plus Tablet affect my thinking or coordination?

Onyx Plus Tablet may cause trouble thinking, drowsiness, or dizziness. Avoid driving or using heavy machinery until you know how it affects you.

Can Onyx Plus Tablet affect my blood sugar or cholesterol levels?

Yes. Onyx Plus Tablet can cause high blood sugar (even leading to diabetes) and high cholesterol or triglyceride levels. These should be monitored with blood tests during Onyx Plus Tablet treatment.

How should I take Onyx Plus Tablet?

Take Onyx Plus Tablet exactly as prescribed, typically once daily in the evening with or without food. Swallow the tablets whole with water. Your doctor may start with a low dose and gradually increase it based on your response and tolerance.

How long does Onyx Plus Tablet take to show results?

The exact time Onyx Plus Tablet takes to show results is not known. However, some symptoms may improve within weeks, but full benefit often takes a few weeks to months of consistent use. Improvement in mood may take longer. You should continue taking it as prescribed even if you don't notice immediate improvements.

Can I drink alcohol while taking Onyx Plus Tablet?

Alcohol should be avoided while taking Onyx Plus Tablet, as it can worsen drowsiness and dizziness and may increase depression symptoms. Combining alcohol with Onyx Plus Tablet can also impair judgment and increase the risk of dangerous behaviors.

What health monitoring is required during Onyx Plus Tablet treatment?

Your doctor may advise regular health monitoring, including weight, blood pressure, blood sugar, and lipid profiles. Your doctor may also order periodic blood tests to check medication levels and monitor for metabolic changes or other side effects.

Fact Box

Habit Forming

Therapeutic Class

NEURO CNS

References

Olanzapine and fluoxetine hydrochloride [Prescribing Information]. Indianapolis, IN: Eli Lilly and Company; 2011. [Accessed 16 Sep. 2024] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Biologic Psychotropics India Pvt Ltd
Address: Near UCO Bank, Nahan Road, Kalaamb, Sirmaur-173030, Himachal Pradesh, India

Vendor Details

Country of origin: India

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Onyx Plus Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Onyx Plus Tablet

Benefits of Onyx Plus Tablet

Side effects of Onyx Plus Tablet

How to use Onyx Plus Tablet

How Onyx Plus Tablet works

All substitutes for Onyx Plus Tablet

Oleanz Plus Tablet

Fostera 20mg/5mg Tablet

Oltha Plus Tablet

Olay Plus Tablet

Elanza Plus Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Onyx Plus Tablet used for?

Can Onyx Plus Tablet be used in children or elderly patients?

What are the serious side effects of Onyx Plus Tablet I should know about?

Does Onyx Plus Tablet cause weight gain?

Can I stop taking Onyx Plus Tablet suddenly?

What should I avoid while taking Onyx Plus Tablet?

Can Onyx Plus Tablet affect my thinking or coordination?

Can Onyx Plus Tablet affect my blood sugar or cholesterol levels?

How should I take Onyx Plus Tablet?

How long does Onyx Plus Tablet take to show results?

Can I drink alcohol while taking Onyx Plus Tablet?

What health monitoring is required during Onyx Plus Tablet treatment?

Fact Box

Habit Forming

Therapeutic Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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