Oncomide 500mg Injection

Reviewed By Dr. Mekhala Chandra, MD, MBBS

Last updated on 25 Nov 2025 | 03:05 PM (IST)

Oncomide 500mg Injection is used in the treatment of different kinds of cancers. It is also used to treat kidney disease known as nephrotic syndrome in children after other treatments have not worked. It may be also used to treat other conditions, as determined by the doctor.

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General Information

Contains

Cyclophosphamide (500mg)

Marketer

Khandelwal Laboratories Pvt Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Oncomide 500mg Injection is given as an injection into a vein by the healthcare professional, but better if injected at the same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include vomiting, nausea, hair loss, fever, and blood in urine. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. It is very strong medicine and some people may develop serious side effects while taking it. This medicine may lower your ability to fight infections and lead to problems with your blood, liver or kidneys. Your doctor will advise you regular blood tests to check for these. It is advised that you drink extra fluids so that you pass more urine. This will help prevent bladder and kidney problems and keep your kidneys working well.

Before taking it, tell your doctor if you have liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Oncomide Injection

Benefits of Oncomide Injection

Cancer
Oncomide 500mg Injection is used in the treatment of various cancers to help shrink tumors, slow disease progression, and improve the effectiveness of other treatments. It can support better outcomes and quality of life during cancer therapy.

Nephrotic syndrome
In nephrotic syndrome, Oncomide 500mg Injection is used to reduce symptoms like swelling and high protein levels in urine. It can help achieve longer periods of remission, reduce the need for frequent steroid use, and support overall kidney health.

Side effects of Oncomide Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Oncomide

Hair loss
Nausea
Infection
Diarrhea
Vomiting
Decreased white blood cell count (neutrophils)
Myelosuppression
Cystitis
Microhematuria
Decreased white blood cell count (lymphocytes)

How to use Oncomide Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Oncomide Injection works

Oncomide 500mg Injection is an anti-cancer medication. It is an alkylating agent which works by damaging the genetic material (DNA and RNA) of the cancer cells, thereby stopping their growth and multiplication. This is how it works against cancer.

All substitutes for Oncomide 500mg Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Oncomide 500mg Injection helps in the treatment of cancer.
It is injected into the vein by a doctor or healthcare professional.
Drink plenty of fluids or urinate frequently to prevent urinary problems while taking this medication.
Your doctor may get regular blood tests to monitor your blood counts while on treatment with this medication.
You are more likely to get sick or heal slower while taking this medication. Talk to your doctor before getting any vaccines.
Contact your doctor immediately if you experience difficulty in urinating or blood in urine while on treatment with this medication.
Do not take Oncomide 500mg Injection if you are pregnant or breastfeeding.
Use effective contraception method to prevent pregnancy while taking this medicine.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Oncomide 500mg Injection

Pregnancy

CONSULT YOUR DOCTOR

Oncomide 500mg Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

UNSAFE

Oncomide 500mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Oncomide 500mg Injection may cause side effects that could affect your ability to drive.
Oncomide 500mg Injection may cause undesirable effects (e.g., dizziness, blurred vision, visual impairment) which could affect the ability to drive.

Kidney

CAUTION

Oncomide 500mg Injection should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Oncomide 500mg Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Oncomide with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Do not use Cyclophosphamide with Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted). If essential, please consult your doctor. Cyclophosphamide may reduce efficacy of Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted).

Severe

Pegfilgrastim (Injection Route)

Do not consume Pegfilgrastim from 24 hours before or 24 hours after taking Cyclophosphamide. Cyclophosphamide may reduce the efficacy of Pegfilgrastim.

Severe

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Do not use Cyclophosphamide with Purified Vi Polysaccharide Typhoid Vaccine. If Cyclophosphamide is essential, ensure a gap of At least 6 months after discontinuing Purified Vi Polysaccharide Typhoid Vaccine. Please consult your doctor. Cyclophosphamide may reduce efficacy of Purified Vi Polysaccharide Typhoid Vaccine.

Severe

Molgramostim (Injection Route)

Do not consume Cyclophosphamide from 1 day before until 1 day after taking Molgramostim. Please consult your doctor.

Severe

Natalizumab (Injection Route)

Do not consume Natalizumab with Cyclophosphamide.

Frequently asked questions

Can Oncomide 500mg Injection cause infertility?

Yes, Oncomide 500mg Injection can cause infertility in both men and women. It may interfere with the normal menstrual cycle in women and may stop sperm production in men. If you are considering becoming parents after the treatment please discuss this with your doctor. Talk to your doctor about cryopreservation (freezing) of sperm or eggs prior to treatment because of the possibility of irreversible infertility due to therapy with Oncomide 500mg Injection.

Do I need to avoid sun exposure during treatment with Oncomide 500mg Injection?

No, there is no evidence that you need to avoid sun exposure while on Oncomide 500mg Injection. Skin and nail discoloration are reported rarely with Oncomide 500mg Injection.

Can Oncomide 500mg Injection cause cancer?

Cancer medicines and radiation therapy can increase the risk of developing other cancers. These may not develop soon and may take a number of years after the completion of your treatment. The risk of developing cancer with Oncomide 500mg Injection is high in the urinary bladder. Other rare cancers that may occur with use of Oncomide 500mg Injection include Acute leukemia, Myelodysplastic syndrome, and cancer of the ureters.

Is Oncomide 500mg Injection chemotherapy medicine?

Yes, Oncomide 500mg Injection is a chemotherapy medicine, it belongs to the class of alkylating agents. It works by killing cancer cells. It is also known as cytotoxic medicine.

Can Oncomide 500mg Injection be used for non-cancer condition?

Yes, Oncomide 500mg Injection can be used to treat nephrotic syndrome (a disease that is caused by damage to the kidneys) in children whose disease has not improved, has gotten worse, or has come back after taking other medications. Along with that, it can be used in children who experienced intolerable side effects with other medications. However, in adults, the safety and effectiveness of Oncomide 500mg Injection for nephrotic syndrome has not been established.

Can Oncomide 500mg Injection causes weight loss?

Yes, Oncomide 500mg Injection may cause weight loss because of reduced appetite. This reduction in weight could be due to underlying cancer. Consult your doctor, if weight loss is worrying you.

Can Oncomide 500mg Injection cause infertility?

Do I need to avoid sun exposure during treatment with Oncomide 500mg Injection?

No, there is no evidence that you need to avoid sun exposure while on Oncomide 500mg Injection. Skin and nail discoloration are reported rarely with Oncomide 500mg Injection.

Can Oncomide 500mg Injection cause cancer?

Is Oncomide 500mg Injection chemotherapy medicine?

Yes, Oncomide 500mg Injection is a chemotherapy medicine, it belongs to the class of alkylating agents. It works by killing cancer cells. It is also known as cytotoxic medicine.

Can Oncomide 500mg Injection be used for non-cancer condition?

Can Oncomide 500mg Injection causes weight loss?

Yes, Oncomide 500mg Injection may cause weight loss because of reduced appetite. This reduction in weight could be due to underlying cancer. Consult your doctor, if weight loss is worrying you.

Fact Box

Chemical Class

Nitrogen mustard compounds

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Alkylating Agents

Related lab tests

Prothrombin Time

Triglycerides

Urine Albumin

References

Lake DF, Briggs AD, Akporiaye ET. Immunopharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 975.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 335-38.
Cyclophosphamide monohydrate. Camberley, Surrey: Sandoz Limited; 2014 [revised 07 Jun. 2017]. [Accessed 26 Mar. 2019] (online) Available from:
Cyclophosphamide. Baxter Health Corporation; 1959. [Accessed 26 Mar. 2019] (online) Available from:
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 26 Mar. 2019] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Khandelwal Laboratories Pvt Ltd
Address: KHANDELWAL LABORATORIES PVT. LTD, 79/87 D.LADPATH, MUMBAI 400 033, INDIA

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Oncomide 500mg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Oncomide 500mg Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Oncomide Injection

Benefits of Oncomide Injection

Side effects of Oncomide Injection

How to use Oncomide Injection

How Oncomide Injection works

All substitutes for Oncomide 500mg Injection

CYCLOXan 500mg Injection

Phosmid 500mg Injection

endoXAN Asta 500mg Injection

Cyphos 500mg Injection

Chophos 500mg Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Pegfilgrastim (Injection Route)

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Molgramostim (Injection Route)

Natalizumab (Injection Route)

Frequently asked questions

Can Oncomide 500mg Injection cause infertility?

Do I need to avoid sun exposure during treatment with Oncomide 500mg Injection?

Can Oncomide 500mg Injection cause cancer?

Is Oncomide 500mg Injection chemotherapy medicine?

Can Oncomide 500mg Injection be used for non-cancer condition?

Can Oncomide 500mg Injection causes weight loss?

Can Oncomide 500mg Injection cause infertility?

Do I need to avoid sun exposure during treatment with Oncomide 500mg Injection?

Can Oncomide 500mg Injection cause cancer?

Is Oncomide 500mg Injection chemotherapy medicine?

Can Oncomide 500mg Injection be used for non-cancer condition?

Can Oncomide 500mg Injection causes weight loss?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Prothrombin Time

Triglycerides

Urine Albumin

References

User feedback

What are you using Oncomide Injection for?

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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