Migablok 40mg/10mg Tablet is a combination of two medicines: Propranolol and Flunarizine which prevent migraine. Propranolol is a beta blocker and Flunarizine is a calcium channel blocker. They work by stabilizing the reactive nerve cells and increasing the threshold to migraine activation. They also inhibit cortical spreading depression (CSD- electric waves that move across the brain and cause pain and inflammation).
Taking Propranolol with alcohol may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate.
WEIGH RISKS VS BENEFITS
Migablok 40mg/10mg Tablet may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
No information is available on the use of Migablok 40mg/10mg Tablet during lactation. Please consult your doctor.
Do not drive unless you are feeling well. Migablok 40mg/10mg Tablet may cause visual disturbances, hallucinations, fatigue, mental confusion, dizziness or tiredness. This may affect your driving ability.
Migablok 40mg/10mg Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Migablok 40mg/10mg Tablet may not be needed in these patients. Please consult your doctor.
Migablok 40mg/10mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Migablok 40mg/10mg Tablet may be needed. Please consult your doctor. Regular monitoring of blood pressure is advisable for dose adjustment.