Migablok 40mg/10mg Tablet is a combination of two medicines: Propranolol and Flunarizine which prevent migraine. Propranolol is a beta blocker and Flunarizine is a calcium channel blocker. They work by stabilizing the reactive nerve cells and increasing the threshold to migraine activation. They also inhibit cortical spreading depression (CSD- electric waves that move across the brain and cause pain and inflammation).
In Depth Information on Migablok Tablet
Migablok Tablet related warnings
Special precautions for Migablok Tablet
Taking Propranolol with alcohol may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate.
WEIGH RISKS VS BENEFITS
Migablok 40mg/10mg Tablet may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
No information is available on the use of Migablok 40mg/10mg Tablet during lactation. Please consult your doctor.
Do not drive unless you are feeling well. Migablok 40mg/10mg Tablet may cause visual disturbances, hallucinations, fatigue, mental confusion, dizziness or tiredness. This may affect your driving ability.
Migablok 40mg/10mg Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Migablok 40mg/10mg Tablet may not be needed in these patients. Please consult your doctor.
Migablok 40mg/10mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Migablok 40mg/10mg Tablet may be needed. Please consult your doctor. Regular monitoring of blood pressure is advisable for dose adjustment.
Q. In which conditions the use of Migablok is contraindicated?
Use of Migablok is contraindicated in patients with allergy to any of the ingredients: Propranolol or Flunarizine or any other excipients. This medicine contains Propranolol, so its use should also be avoided in patients with asthma, slow heart rate, abnormal heart rhythms, or heart conditions like AV block or sick sinus syndrome. As it also contains Flunarizine, the use of this medicine should be avoided in patients with the history of depression or Parkinson's disease.
Q. What are the instructions for the storage and disposal of Migablok?
Keep Migablok in the container or pack it came in, tightly closed. Store it as mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children, and other people.
Q. Can I stop taking Migablok when my symptoms are improved?
Migablok is given as a prophylactic treatment for the prevention of migraine headaches. Do not stop taking this medicine until advised by your doctor as it may cause your migraine episodes to return. Also, it should not be stopped suddenly as it contains Propranolol and a sudden withdrawal of Propranolol may cause sweating, shaking, irregular or fast heartbeat, worsening of underlying angina or heart attack. You must take Migablok exactly as advised by your doctor.
Q. Can Migablok be used for the treatment of a migraine headache?
No, Migablok does not help in relieving a migraine headache that has already started. It can only be used for preventing the new episode of a migraine headache.
Information last updated by Dr. Varun Gupta, MD Pharmacology on 5th Jul 2018.