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Metaglez Tablet

Prescription Required

Primary uses of Metaglez Tablet

Potentiallyunsafewith
Alcohol
MRP
4.76
₹0.48/Tablet
10 tablets in 1 strip
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Medicine Overview of Metaglez Tablet

Uses of Metaglez Tablet

Metaglez Tablet is used in the treatment of type 2 diabetes.

Metaglez Tablet side effects

Common

Side Effects of Metaglez are Hypoglycemia (low blood sugar level), Taste change, Nausea, Stomach pain, Diarrhoea, Headache, Upper respiratory tract infection.

How to use Metaglez Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Metaglez Tablet is to be taken with food.
Metaglez Tablet may cause stomach upset if taken on empty stomach

How Metaglez Tablet works

Metaglez Tablet is a combination of two antidiabetic medicines: Glipizide and Metformin. Glipizide is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide which works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin.

In Depth Information on Metaglez Tablet

Expert advice for Metaglez Tablet

  • You have been prescribed this combination medicine as it can control blood sugar better than metformin alone.
  • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Metaglez Tablet.
  • Take it with food to lower your chance of having an upset stomach.
  • Monitor your blood sugar level regularly while you are taking this medicine. 
  • Inform your doctor about your diabetes treatment if you are due to have surgery under a general anaesthetic.
  • It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. 
  • Tell your doctor immediately if you experience any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain as Metaglez Tablet may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
  • Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
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Metaglez Tablet related warnings
Special precautions for Metaglez Tablet
Alcohol
CAUTION
Taking metformin with alcohol can cause lactic acidosis and you may experience malaise, respiratory distress, slow or irregular heartbeat, sleepiness, stomach upset, or other unusual symptoms.
Pregnancy
WEIGH RISKS VS BENEFITS
Metaglez Tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Lactation
Metaglez Tablet is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby.
Driving
Your ability to drive may be affected if your blood sugar is low or high. If this happens, do not drive.
Kidney
CAUTION
Metaglez Tablet should be used with caution in patients with kidney disease. Dose adjustment of Metaglez Tablet may be needed. Please consult your doctor.
Use of Metaglez Tablet is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
Liver
CAUTION
Metaglez Tablet should be used with caution in patients with liver disease. Dose adjustment of Metaglez Tablet may be needed. Please consult your doctor.
Metaglez Tablet is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease.

Patient Concerns

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Frequently asked questions about Metaglez Tablet

Frequently asked questions about Metaglez Tablet

Q. What is Metaglez?
Metaglez is a combination of two medicines: Glipizide and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus (DM) along with diet and exercise to improve blood glucose levels in adults. Glipizide lowers the blood glucose levels by increasing the release of insulin from the pancreas. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. This combination is not indicated for the treatment of Type 1 DM.
Q. What are the possible side effects of Metaglez?
The use of Metaglez is associated with common side effects like hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious, but rare side effects like lactic acidosis. On long-term use, it can also lead to Vitamin B12 deficiency.
Q. Can the use of Metaglez cause hypoglycemia?
Yes, the use of Metaglez can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your food, drink alcohol, do more than routine exercise or take other antidiabetic medicine along with. So, regular monitoring of blood sugar level is important. Always try to keep some glucose tablets, honey or fruit juice with you.
Q. Can the use of Metaglez cause lactic acidosis?
Yes, the use of Metaglez can lead to lactic acidosis. It is a medical emergency which is caused by increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect associated with the use of metformin and therefore, it is contraindicated in patients with underlying kidney disease, old age patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain or slow heart rate. If you have these symptoms, stop taking Metaglez and immediately consult your doctor.
Q. Can the use of Metaglez lead to Vitamin B12 deficiency?
Yes, the use of Metaglez can cause vitamin B12 deficiency on long-term use as it interferes with absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can have tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in making balance (ataxia). To avoid such problems, some researchers suggest an intake of vitamin B12 from outside at least once every year.
Q. Are there any specific conditions in which Metaglez should not to be taken?
The use of Metaglez should be avoided in patients with known allergy to any of the component or excipients of this medicine, in patients with moderate to severe kidney disease and in patients with underlying metabolic acidosis including diabetic ketoacidosis.
Q. Is it safe to take alcohol while I am also taking Metaglez?
No, it is not safe to take Metaglez along with alcohol, as it may lower your low blood sugar levels (hypoglycemia) and can increase the chances of lactic acidosis.
Q. Does Metaglez expire?
Yes, Metaglez does expire. The expiry date is written on the pack of the medicine and it refers to the last day of the month mentioned. Do not use Metaglez after the expiry date.
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