Melgain Lotion

Prescription Required
Store at room temperature (10-30°C)


Melgain Lotion is a medicine for the treatment of vitiligo. It is effectively used in combination with other treatment methods for best results. It lightens the skin by increasing the elimination of melanin (skin-darkening pigment) from skin cells.

Melgain Lotion is for external use only. You should always use it exactly as your doctor has told you. The affected area should be clean and dry before application. You must wash your hands thoroughly before and after applying this medicine. This medicine should be used regularly to get the most benefit from it. Do not use more than you need as it will not clear your condition faster and some side effects may be increased. If your condition goes on for longer than four weeks or gets worse at any time, let your doctor know. You can help this medicine work better by keeping the affected areas clean.

Common side effects include dry skin, skin irritation, and burning sensation at the site of application. Please consult your doctor if these side effects persist for a longer duration. Avoid direct contact of the cream or ointment with your eyes. In case of direct contact, wash your eyes with water and seek immediate medical attention.

This medicine can make your skin more sensitive to sun. Use sunscreen and protective clothing when outdoors. Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy or breastfeeding.

Uses of Melgain Lotion

Benefits of Melgain Lotion

In Vitiligo

Vitiligo is a condition in which the ski loses its natural color in patches. Melgain Lotion effectively blocks that process in the skin that leads to discoloration. It also reduces any redness, rash, pain or itchiness that may be caused in this condition. This improves your self-esteem and confidence as your appearance changes. You should always use it as prescribed to get the full benefits.

Side effects of Melgain Lotion

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Melgain

  • Dry skin
  • Skin irritation
  • Burning sensation

How to use Melgain Lotion

This medicine is for external use only. Use this medicine in the dose and duration as advised by your doctor. Shake it well and apply to the area evenly.

How Melgain Lotion works

Melgain Lotion is a repigmenting agent. It works by causing migration of skin cells (melanocytes) from the area of skin surrounding the vitiligo patch. This in turn causes the production of melanin (skin darkening pigment) and restores the skin colour.

Safety Advice

No interaction found/established
Information regarding the use of Melgain Lotion during pregnancy is not available. Please consult your doctor.
Information regarding the use of Melgain Lotion during breastfeeding is not available. Please consult your doctor.
No interaction found/established
No interaction found/established
No interaction found/established

What if you forget to take Melgain Lotion?

If you miss a dose of Melgain Lotion, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
No alternate brands found for this medicine

Quick Tips

  • Melgain Lotion helps lighten the skin in people with vitiligo.
  • It may take up to 4 months to complete treatment. Keep using the medication as prescribed.
  • Apply it in a thin layer to the pigmented areas of skin and rub in gently.
  • It can make your skin more sensitive to sun. Use sunscreen and protective clothing when outdoors. 
  • It may also cause changes in the color of your untreated skin. Talk to your doctor if this bothers you.
  • Inform your doctor if your condition does not improve after 1 month of treatment.

Fact Box

Habit Forming
Therapeutic Class

Patient Concerns

I had a white patches on my lower lips. I have used MELGAIN solution. It gives good result. But it is too cost. Which medicine I can used for white patches? Which medicine I can use for white patches on my lips?
Dr. Souvik Sardar
For lips melgain is a very good medicine Another medicine is there which cost more than melgain Please continue melgain. If it's giving better response
vitiligo on lips, my father also vitiligo
Dr. Atul Jain
Difficult to treat, you should visit skin specialist for proper examination and treatment
Do you have any questions related to Melgain Lotion ?

User Feedback


Q. How do you use a Melgain Lotion?

Use Melgain Lotion exactly as directed by your doctor. Read the instructions carefully before using. Clean and dry the affected area thoroughly and then apply the lotion as a very thin film. For best results, apply it about 2 hours before retiring at night. Do not touch the treated patches for about an hour. Next morning, expose the patches to bright sunlight for 10-15 minutes. If not possible to expose to sunlight, you can use ultraviolet lamps.

Q. How does Melgain Lotion work?

Melgain Lotion increases the growth of cells that make pigment (melanocytes). It increases melanocytes in the area of patches (hypopigmented area). It also helps the melanocytes to migrate to the affected area, thus restoring skin complexion.

Q. How safe is Melgain Lotion?

Melgain Lotion is quite safe if used as prescribed. No side effects or contraindications have been reported so far. If you experience any side effects after applying the lotion, consult your doctor immediately.

Q. How long do I need to use Melgain Lotion?

The duration of treatment depends on the response to treatment. The response is faster in children or if used in recently developed patches. Normally, re-pigmentation can be seen on the borders or inside the white patch (as dots of pigment) in 3 to 6 months depending on the age of the white patch. In the majority of patients, full re-pigmentation may take a year.

Q. Can childhood vitiligo go away?

There is still no remedy which cures vitiligo 100%. Sometimes the patches may disappear on their own. But generally, the patches may get repigmented, but never get cured completely.

Q. What is vitiligo?

Vitiligo is an autoimmune disease of the skin that causes white patches on the skin due to loss of normal skin pigment called melanin. It occurs when the cells that give your skin its color are destroyed. These patches can also affect the eyes, mouth and nose. It runs in families and usually starts before the age of 40 years.

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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.


  1. Gianfaldoni S, Tchernev S, Wollina U, et al. Vitiligo in Children: What’s New in Treatment? Open Access Maced J Med Sci. 2018;6(1):221-225. [Accessed 25 Feb. 2020] (online) Available from:External Link
  2. Fox LP, Merk HF, Bickers DR. Dermatological Pharmacology. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1679-1706.

Manufacturer/Marketer Address

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
Country of Origin: India

Expires on or after: October, 2021

A licensed vendor partner from your nearest location will deliver Melgain Lotion. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
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