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Mefnil Plus 500mg/325mg Tablet

Mefenamic Acid (500mg)+ Paracetamol (325mg)
Genuine
Authenticity Assured
Prescription
required
Mefnil Plus 500mg/325mg Tablet is a combination of two medicines used in the treatment of fever. It is also useful for the treatment of mild to moderate pain of various conditions like headache, body ache, and toothache. It works by reducing chemical messengers that cause pain, inflammation, and fever.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 04 Aug 2026 | 01:04 AM (IST)
₹37.9 MRP ₹44.0614% off 
Gurgaon
 
 
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Spastone P 500mg/325mg Tablet
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Mefnil Plus 500mg/325mg Tablet
Mefnil Plus 500mg/325mg Tablet
strip of 10 tablets
₹37.9
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Same composition
Spastone P 500mg/325mg Tablet
Spastone P 500mg/325mg Tablet
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Mefenamic Acid (500mg) + Paracetamol (325mg)
by Leeford Healthcare Ltd
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₹74.3
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General Information

Contains

Mefenamic Acid (500mg)+ Paracetamol (325mg)

Marketer

Pharmafabrikon

Storage

Store below 30°C
The content is shown in English
Mefnil Plus 500mg/325mg Tablet image
Mefnil Plus 500mg/325mg Tablet image

Product introduction

Mefnil Plus 500mg/325mg Tablet is to be taken with food. This will prevent you from getting an upset stomach. The dose will depend on what you are taking it for and how well it helps your symptoms. You should take it as advised by your doctor. Do not take more or use it for a longer duration than recommended by the doctor.

The most common side effects of this medicine include nausea, vomiting, diarrhea, indigestion, loss of appetite, and heartburn. If any of these side effects bother you or get worse, you should speak to your doctor. Your doctor may be able to suggest ways of preventing or reducing the side effects.

Before taking it, you should let your doctor know if you have a history of ulcers or bleeding in your stomach, high blood pressure, or any trouble with your heart, kidneys, or liver. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine.

Uses of Mefnil Plus Tablet

  • Pain relief : Mefnil Plus 500mg/325mg Tablet helps relieve pain in conditions such as headache, body ache, muscle pain, toothache, menstrual cramps, and minor injuries.
  • Treatment of Fever : Mefnil Plus 500mg/325mg Tablet helps reduce fever in conditions such as flu, viral infections, post-vaccination reactions, and other illnesses associated with fever.

Benefits of Mefnil Plus Tablet

Pain relief
Pain can occur due to inflammation or injury affecting different parts of the body. Mefnil Plus 500mg/325mg Tablet works by blocking chemical messengers responsible for pain and inflammation. This helps reduce discomfort in conditions such as headache, toothache, muscle pain, joint pain, and menstrual cramps. It improves daily functioning and provides effective short-term relief from pain.
Treatment of Fever
Fever is usually a sign of infection or inflammation in the body. Mefnil Plus 500mg/325mg Tablet helps reduce high temperature by blocking chemical messengers that trigger fever. This brings down body temperature and relieves associated symptoms such as body aches and discomfort.

Side effects of Mefnil Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Mefnil Plus
  • Vomiting
  • Diarrhea
  • Nausea
  • Indigestion
  • Loss of appetite
  • Heartburn
  • Hypersensitivity
  • Skin rash

How to use Mefnil Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Mefnil Plus 500mg/325mg Tablet should be taken with or after food.

How Mefnil Plus Tablet works

Mefnil Plus 500mg/325mg Tablet is a combination of two medicines: Mefenamic Acid and Paracetamol. It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling).

All substitutes for Mefnil Plus 500mg/325mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Meftal-Forte Tablet

by Blue Cross Laboratories Ltd
₹3.8/tablet
same price
<h3 class=bodySemiBold>Meftal-Forte Tablet</h3>

Meftagesic 500mg/325mg Tablet

by Blue Cross Laboratories Ltd
₹4.06/tablet
7% costlier
<h3 class=bodySemiBold>Meftagesic 500mg/325mg Tablet</h3>

Mefkind Forte Tablet

by Mankind Pharma Ltd
₹4.3/tablet
13% costlier
<h3 class=bodySemiBold>Mefkind Forte Tablet</h3>

Pacimol MF Tablet

by Ipca Laboratories Ltd
₹4.44/tablet
17% costlier
<h3 class=bodySemiBold>Pacimol MF Tablet</h3>

Biospas Forte Tablet

by Biochem Pharmaceutical Industries
₹6.41/tablet
69% costlier
<h3 class=bodySemiBold>Biospas Forte Tablet</h3>

Quick tips

  • Take Mefnil Plus 500mg/325mg Tablet with food to reduce the risk of stomach irritation.
  • Avoid taking Mefnil Plus 500mg/325mg Tablet with other medicines containing paracetamol or other NSAIDs unless advised by your doctor.
  • Mefnil Plus 500mg/325mg Tablet may cause dizziness or sleepiness, so avoid driving or operating machinery until you know how it affects you.
  • Stop taking Mefnil Plus 500mg/325mg Tablet and consult your doctor if you develop diarrhea while using this medicine.
  • Watch for warning signs such as severe stomach pain or black/tarry stools, and seek medical attention if they occur.
  • Avoid alcohol while taking Mefnil Plus 500mg/325mg Tablet as it may increase drowsiness and the risk of stomach or liver problems.
  • Stay well hydrated while taking Mefnil Plus 500mg/325mg Tablet, as dehydration may increase the risk of kidney-related side effects.
  • Inform your doctor if you develop rash, swelling, or other signs of allergy while taking Mefnil Plus 500mg/325mg Tablet.
  • Do not use Mefnil Plus 500mg/325mg Tablet for long periods without medical supervision.
  • Your doctor may monitor kidney function, liver function, and blood parameters if Mefnil Plus 500mg/325mg Tablet is used for long-term treatment.
  • Inform your doctor if you have a history of kidney disease, liver disease, or stomach ulcers before taking Mefnil Plus 500mg/325mg Tablet.
  • Do not increase the dose or frequency of Mefnil Plus 500mg/325mg Tablet without medical advice.
  • Consult your doctor if pain or fever persists or keeps recurring despite taking Mefnil Plus 500mg/325mg Tablet.

Safety advice

Alcohol

Alcohol

CAUTION
Alcohol should be used with caution while taking Mefnil Plus 500mg/325mg Tablet.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Mefnil Plus 500mg/325mg Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Mefnil Plus 500mg/325mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Mefnil Plus 500mg/325mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

CAUTION
Mefnil Plus 500mg/325mg Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Use of Mefnil Plus 500mg/325mg Tablet is not recommended in patients with severe kidney disease.
Liver

Liver

UNSAFE
Mefnil Plus 500mg/325mg Tablet is unsafe to use in patients with liver disease and should be avoided.
However, the use of Mefnil Plus 500mg/325mg Tablet is not recommended in patients with severe liver disease and active liver disease.
All

Frequently asked questions

Mefnil Plus 500mg/325mg Tablet may cause some common side effects such as nausea, stomach pain, heartburn, or diarrhea. Some people may also experience vomiting or dizziness. These effects often occur because the medicine can irritate the stomach lining. Taking Mefnil Plus 500mg/325mg Tablet with food or milk may help reduce stomach discomfort. In rare cases, it may cause serious problems such as stomach bleeding or kidney damage. Seek medical attention if you notice warning signs such as black stools, vomiting blood, or severe stomach pain.
Mefnil Plus 500mg/325mg Tablet is usually prescribed for short-term use to relieve pain. In many cases, it can be stopped once the pain improves. However, if your doctor has advised you to take it for a specific period, you should continue using it for the recommended duration. Always follow your doctor’s instructions before stopping any prescribed medicine.
Mefnil Plus 500mg/325mg Tablet should be avoided by people who are allergic to this medicine or to other similar pain relievers known as NSAIDs. It is also not recommended for individuals with stomach ulcers, active stomach bleeding, severe liver disease, or serious kidney problems. People who have a history of stomach irritation or bleeding should only take it if advised by a doctor. Always inform your doctor about your medical history and any other medicines you are taking before starting Mefnil Plus 500mg/325mg Tablet.
Yes, Mefnil Plus 500mg/325mg Tablet can usually be taken with vitamin B-complex supplements. While Mefnil Plus 500mg/325mg Tablet helps relieve pain, vitamin B-complex may help correct vitamin deficiencies that could contribute to certain types of pain, such as nerve-related discomfort. However, it is still best to consult your doctor before combining medications or supplements.
Mefnil Plus 500mg/325mg Tablet may affect the kidneys or liver if it is used for a long time or taken in higher-than-recommended doses. The medicine can reduce protective substances that help maintain kidney function, which may lead to kidney damage. Misuse or combining it with other medicines containing similar ingredients may also strain the liver. The risk is higher in people who already have kidney or liver disease. Always take Mefnil Plus 500mg/325mg Tablet only as prescribed and avoid unnecessary or prolonged use.
No, taking more than the recommended dose of Mefnil Plus 500mg/325mg Tablet can increase the risk of side effects such as nausea, vomiting, indigestion, heartburn, and diarrhea. Overuse may also harm the kidneys, especially with long-term use. If your pain is severe or not relieved by the prescribed dose, consult your doctor instead of increasing the dose on your own.
Mefnil Plus 500mg/325mg Tablet is a medicine used for short-term relief of pain and fever. It is commonly prescribed for menstrual cramps (period pain), dental pain, headaches, muscle or joint pain, and general body aches. It works by reducing certain substances in the body that cause pain, inflammation, and fever. While it helps relieve symptoms, it does not treat the underlying cause of the pain. Always take Mefnil Plus 500mg/325mg Tablet exactly as directed by your doctor and avoid long-term or unnecessary use.
Mefnil Plus 500mg/325mg Tablet is generally not recommended during pregnancy unless your doctor specifically advises it. Anti-inflammatory pain medicines can affect pregnancy and the baby, especially during the later stages. Mefenamic acid may affect the baby’s circulation and kidney function later in pregnancy and may also increase bleeding risk. If you are pregnant, think you may be pregnant, or are planning pregnancy, consult your doctor before taking Mefnil Plus 500mg/325mg Tablet.
It is best to avoid alcohol while taking Mefnil Plus 500mg/325mg Tablet. Alcohol can increase the risk of stomach irritation and bleeding, and it may also add stress to the liver when combined with certain pain medicines. If you drink alcohol regularly, discuss this with your doctor before taking Mefnil Plus 500mg/325mg Tablet.
The active ingredient in Mefnil Plus 500mg/325mg Tablet, mefenamic acid, is gradually cleared from the body, although the exact time can vary depending on factors such as age, liver and kidney function, and hydration. Even after the medicine starts leaving the body, stomach irritation or bleeding risk may persist for some time. If you are planning surgery or have kidney problems, inform your doctor that you have taken Mefnil Plus 500mg/325mg Tablet so they can advise you appropriately.

Fact Box

Habit Forming

No

Therapeutic Class

PAIN ANALGESICS

Related lab tests

Complete Blood Count

References

  1. FDA approved prescribing information. Mefenamic Acid; 2008 [revised Mar. 2007]. [Accessed 02 Apr. 2019] (online) Available from:
  2. ScienceDirect. Mefenamic Acid. [Accessed 02 Apr. 2019] (online) Available from:
  3. ScienceDirect. Paracetamol/Acetaminophen. [Accessed 23 Apr. 2019] (online) Available from:
  4. Paracetamol and Mefenamic acid. Centaur; [Accessed 16 Jan. 2026] (online). Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Pharmafabrikon
Address: 1/332, Othappati, Karuppayurani, Post, Madurai, Tamil Nadu 625020

Vendor Details

Country of origin: India

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