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Macox-ZH Tablet is a combination medicine used in the treatment of tuberculosis. It prevents the growth of the microorganisms that cause the infection.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 19 Jun 2026 | 02:37 PM (IST)
₹59.2 MRP ₹66.3311% off 
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General Information

Contains

Isoniazid (150mg)+ Pyrazinamide (750mg)+ Rifampicin (225mg)

Marketer

Macleods Pharmaceuticals Pvt Ltd

Storage

Store below 30°C
The content is shown in English
Macox-ZH Tablet image
Macox-ZH Tablet image
Macox-ZH Tablet image
Macox-ZH Tablet image
Macox-ZH Tablet image
Macox-ZH Tablet image

Product introduction

Macox-ZH Tablet is a prescription medicine and it is to be taken it as suggested by the doctor. It should be taken in an empty stomach and take it at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine. The medicine may take some to show its effects on the symptoms. However, it is advised to consult the doctor if you feel an aggravation of the condition or if your condition does not improve.

Some common side effects of this medicine are nausea, vomiting, fever, dark-colored urine, sweating, increased saliva, etc. To cope up with the side effects, you should drink plenty of water. If any of the side effects get aggravated, you must consult your doctor immediately. Generally, serious side effects are rare. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.

Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Patients with liver and kidney ailments must take this medicine with proper consultation and caution. Pregnant or breastfeeding women should also consult with the doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. During the treatment, you must take adequate rest and eat a healthy diet for a faster recovery. While on the medication, your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body.

Uses of Macox-ZH Tablet

Benefits of Macox-ZH Tablet

Tuberculosis (TB)
Macox-ZH Tablet is used to treat tuberculosis, an infectious disease that mainly affects the lungs but can affect other parts of the body as well. It kills as well as stops the growth of infection causing bacteria and helps in treating the infection. Take it in the dose and duration advised by the doctor. Your symptoms may improve before the infection is completely cured. Do not stop taking it without consulting your doctor as doing so may cause the infection to return or worsen. Follow your doctor’s instructions carefully to get maximum benefit.

Side effects of Macox-ZH Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Macox-ZH
  • Skin rash
  • Hepatitis (viral infection of liver)
  • Lethargy
  • Low blood platelets
  • Thrombocytopenic purpura
  • Cutaneous reactions
  • Nausea
  • Vomiting
  • Peripheral neuropathy (tingling and numbness of feet and hand)
  • Abdominal pain

How to use Macox-ZH Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Macox-ZH Tablet is to be taken on an empty stomach.
Avoid Macox-ZH Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

How Macox-ZH Tablet works

Macox-ZH Tablet is a combination of three medicines: Isoniazid, Pyrazinamide and Rifampicin which treat tuberculosis. Isoniazid prevents the TB bacteria from forming their own protective covering while Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by these bacteria to make essential proteins and to reproduce. Together, they kill the bacteria and eradicate the infection. Pyrazinamide, on the other hand works by slowing the growth of these bacteria.

Quick tips

  • Macox-ZH Tablet should be taken on an empty stomach but at the same time every day.
  • Do not skip any doses and finish the full course of treatment even if you feel better.
  • It may cause dizziness. Don't drive or do anything that requires mental focus until you know how Macox-ZH Tablet affects you.
  • Avoid drinking alcohol while taking this medicine as this may increase the risk of side effects on the liver.
  • Avoid taking hormone-based birth control methods as Macox-ZH Tablet may decrease their effectiveness.
  • Your doctor may monitor your liver function, vision and thyroid function while on treatment with this medicine.

Safety advice

Alcohol

Alcohol

UNSAFE
Consumption of alcohol with Macox-ZH Tablet may cause a disulfiram-like reaction, leading to symptoms such as flushing, increased heart rate, low blood pressure, nausea, lightheadedness, and severe headache.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Macox-ZH Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

SAFE IF PRESCRIBED
Macox-ZH Tablet may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Driving

Driving

UNSAFE
Macox-ZH Tablet may cause side effects that could affect your ability to drive.
You may feel dizzy or faint, have problems with vision or have other side effects that could affect your ability to drive.
Kidney

Kidney

CAUTION
Macox-ZH Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Macox-ZH Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.
Regular monitoring of liver function tests is advised before and after the start of the treatment.

Frequently asked questions

Macox-ZH Tablet is an anti-tuberculosis medicine used in children for the treatment of tuberculosis (TB). It contains a combination of medicines that help kill TB-causing bacteria and prevent them from multiplying in the body. It is usually prescribed as part of a complete TB treatment plan and helps control the infection while reducing the risk of disease progression.
Macox-ZH Tablet contains Isoniazid, Rifampicin, and Pyrazinamide, which work together against tuberculosis bacteria in different ways. Isoniazid interferes with the protective cell wall of the bacteria, Rifampicin blocks bacterial growth and multiplication. Pyrazinamide helps kill TB bacteria, especially during the early phase of treatment. Using multiple medicines together helps improve treatment effectiveness and lowers the risk of drug resistance.
Rifampicin is absorbed better when taken on an empty stomach. Taking the medicine before meals may help it work more effectively against TB bacteria. If stomach discomfort occurs, follow your doctor's advice regarding administration.
Yes. Rifampicin may cause orange, red, or reddish-brown discoloration of urine, sweat, tears, and other body fluids. This phenomenon is a known effect of the medicine and is usually not harmful. Soft contact lenses may also become permanently stained.
Some children may start feeling better within a few weeks after starting treatment. However, TB bacteria take much longer to clear completely, and treatment usually continues for several months. Even if symptoms improve early, the infection may still be present and treatment should be continued as prescribed.
Stopping TB treatment early may allow the infection to return and can increase the risk of drug-resistant tuberculosis, which is much harder to treat. Even if your child appears completely well, the full prescribed treatment duration should be completed.
Yes. Isoniazid may sometimes cause peripheral neuropathy, which can lead to tingling, numbness, burning sensations, or nerve discomfort, especially in susceptible individuals. Doctors may prescribe Vitamin B6 (Pyridoxine) along with treatment to help reduce this risk.
Seek medical attention if your child develops yellowing of the eyes or skin, dark urine, persistent nausea, vomiting, severe tiredness, abdominal pain, loss of appetite, or unusual weakness. These may be signs of liver-related side effects that require prompt evaluation.
The medicines in Macox-ZH Tablet may affect liver function in some children. Periodic liver function tests help doctors monitor treatment safety and identify liver-related side effects early if they occur. Monitoring may be especially important in children with existing liver problems or prolonged treatment.
Isoniazid may interact with foods containing high amounts of tyramine or histamine. Certain aged cheeses, cured or fermented foods, smoked meats, and some fish products may increase the risk of unwanted reactions in sensitive individuals. Follow the dietary advice provided by your doctor during treatment.
Yes. Rifampicin may affect how several medicines work in the body. It may interact with hormonal contraceptives, blood thinners, anti-epileptic medicines, immunosuppressants, and certain long-term treatments. Always inform your doctor about all medicines, supplements, or syrups your child is taking.
Give the missed dose as soon as you remember. If it is nearly time for the next scheduled dose, skip the missed dose and continue the regular schedule. Do not give a double dose to make up for a missed one.
Some children may experience dizziness, headache, difficulty concentrating, or visual disturbances during treatment. If these symptoms become severe, persistent, or interfere with daily activities, inform your doctor.
Seek medical attention if your child develops unusual bruising, bleeding gums, nosebleeds, tiny red spots on the skin, persistent fever, or unusual weakness. These symptoms may require medical evaluation and blood testing.
Yes. Inform the doctor before starting treatment if your child has liver disease, jaundice, hepatitis, kidney problems, gout, diabetes, or any other significant medical condition. Macox-ZH Tablet contains Isoniazid, Pyrazinamide, and Rifampicin, which can affect the liver, and Pyrazinamide may increase uric acid levels, potentially worsening gout. Also tell the doctor about any history of alcohol-related liver disease, unexplained fatigue, loss of appetite, persistent nausea, or yellowing of the skin or eyes. Providing a complete medical history helps the doctor determine whether Macox-ZH Tablet is suitable and whether any additional tests or precautions are needed during treatment.
Yes. Alcohol may increase the risk of liver-related side effects associated with anti-tuberculosis medicines. Alcohol-containing preparations should only be used after medical advice. Avoiding alcohol exposure during treatment is generally recommended.
Signs that treatment is working may include improvement in fever, appetite, energy levels, weight gain, reduced cough, and overall improvement in symptoms. Doctors may also monitor progress through clinical evaluation and investigations when required. Even when symptoms improve, treatment should be continued for the full prescribed duration.
After the intensive phase of treatment, your child's doctor may adjust the medicines depending on the treatment plan and response. The exact duration varies depending on the type of TB and clinical progress. Regular follow-up visits remain important throughout treatment.

Fact Box

Habit Forming

No

Therapeutic Class

ANTI INFECTIVES

Related lab tests

Complete Blood Count

Erythrocyte Sedimentation Rate

Mycobacterium Tuberculosis DNA PCR - Qualitative

Peripheral Smear Examination

References

  1. Zenner D, Beer N, Harris RJ, et al. Treatment of Latent Tuberculosis Infection: An Updated Network Meta-analysis. Ann Intern Med. 2017;167(4):248-255. [Accessed 29 Nov. 2025]. Available from:
  2. Ramachandran G, Hemanth Kumar AK, Kannan T, et al. Pharmacokinetics of rifampicin, isoniazid & pyrazinamide during daily & intermittent dosing: A preliminary study. Indian J Med Res. 2023;157(2&3):211-215. [Accessed 29 Nov. 2025]. Available from:
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User feedback

Once A Day
88%
Twice A Day
8%
Thrice A Day
4%
Tuberculosis (TB)
78%
Others
22%
Poor
44%
Excellent
33%
Average
22%
No Side Effect
40%
Skin rash
20%
Increased liver enzymes
20%
Peripheral neuropathy (tingling and numbness of feet and hand)
20%
With or without food
50%
With food
25%
Empty stomach
25%
Average
100%
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Macleods Pharmaceuticals Pvt Ltd
Address: Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.

Vendor Details

Country of origin: India

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