


Losulp 25mg Injection
Levosulpiride (25mg)
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Losulp 25mg Injection is used in the treatment of gastric problems like nausea, vomiting, heartburn, or indigestion. It also prevents acid reflux (acid going up to the food pipe) and hence helps in the treatment of gastroesophageal reflux disease (GERD).
Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 23 Jan 2026 | 05:35 PM (IST)
Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 23 Jan 2026 | 05:35 PM (IST)
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General Information
The content is shown in English



Product introduction
Losulp 25mg Injection is taken by mouth with or without food. However, it is advisable to take it at the same time each day as this helps to maintain consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember.
Some common side effects of this medicine includes headache and fatigue. It also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. You should immediately consult doctor if you have absence of periods, abnormal milk secretion, changes in sexual desire, or fever after taking this medicine.
Uses of Losulp Injection
Benefits of Losulp Injection
Heartburn
Heartburn is caused by stomach acid irritating the food pipe, leading to a burning sensation in the chest. Losulp 25mg Injection helps improve stomach emptying and reduces acid-related discomfort, which helps relieve burning sensations and improves eating comfort.
Heartburn is caused by stomach acid irritating the food pipe, leading to a burning sensation in the chest. Losulp 25mg Injection helps improve stomach emptying and reduces acid-related discomfort, which helps relieve burning sensations and improves eating comfort.
Irritable bowel syndrome
Irritable bowel syndrome is a digestive condition that causes abdominal pain, bloating, and irregular bowel movements. Losulp 25mg Injection helps improve gut movement and reduces discomfort, which can ease bloating, pain, and bowel irregularity, supporting better digestive comfort.
Irritable bowel syndrome is a digestive condition that causes abdominal pain, bloating, and irregular bowel movements. Losulp 25mg Injection helps improve gut movement and reduces discomfort, which can ease bloating, pain, and bowel irregularity, supporting better digestive comfort.
Gastroesophageal reflux disease (Acid reflux)
Acid reflux occurs when stomach contents flow back into the food pipe, causing irritation and discomfort. Losulp 25mg Injection helps reduce reflux episodes by supporting proper stomach movement, which lowers acid backflow and improves long-term symptom control and quality of life.
Acid reflux occurs when stomach contents flow back into the food pipe, causing irritation and discomfort. Losulp 25mg Injection helps reduce reflux episodes by supporting proper stomach movement, which lowers acid backflow and improves long-term symptom control and quality of life.
Side effects of Losulp Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Losulp
- Increased prolactin level in blood
- Insomnia (difficulty in sleeping)
- Sedation
- Maculopapular rash
- Extrapyramidal symptoms
- Akathisia (inability to stay still)
- Increased liver enzymes
- Constipation
- Weight gain
How to use Losulp Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Losulp Injection works
Losulp 25mg Injection is a atypical antipsychotic. It works by increasing the release of acetylcholine (a chemical messenger). This increases the movement of stomach and intestines, and prevents reflux (acid going up to the food pipe).
All substitutes for Losulp 25mg Injection
For information purposes only. Consult a doctor before taking any medicine.
Quick tips
- Take it as per dose and duration suggested by your doctor.
- Losulp 25mg Injection may cause dizziness. Do not drive or do anything that requires mental focus until you know how this medicine affects you.
- Consult your doctor if you are pregnant, planning to become pregnant or breastfeeding.
- Consult with your doctor immediately if you have absence if periods, abnormal milk secretion or changes in sexual desire, fever, muscle stiffness.
Safety advice

Alcohol
UNSAFE
It is unsafe to consume alcohol with Losulp 25mg Injection

Pregnancy
CONSULT YOUR DOCTOR
Losulp 25mg Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Losulp 25mg Injection during breastfeeding is not available. Please consult your doctor.

Driving
UNSAFE
Losulp 25mg Injection may cause side effects that could affect your ability to drive.
Losulp 25mg Injection may cause drowsiness, numbness, or dyskinesias, therefore they should be advised to avoid driving and operations requiring supervision.
Losulp 25mg Injection may cause drowsiness, numbness, or dyskinesias, therefore they should be advised to avoid driving and operations requiring supervision.

Kidney
CAUTION
Losulp 25mg Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver
CAUTION
Losulp 25mg Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.
Interaction with drugs
Taking Losulp with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Frequently asked questions
Losulp 25mg Injection is mainly used to treat gastric problems like nausea, vomiting, heartburn, or indigestion. This medicine may be used sometimes to manage mental health conditions like depression or schizophrenia, depending on the dose.
Although rare, serious side effects of Losulp 25mg Injection may include muscle stiffness or shaking, high fever (possible neuroleptic malignant syndrome), seizures, and abnormal heart rhythm. You should seek immediate help if you notice any of these symptoms.
Individuals should not take Losulp 25mg Injection if they are allergic to any ingredient present in Losulp 25mg Injection, have epilepsy or seizures, have breast cancer or tumors dependent on prolactin, or have severe kidney or liver disease.
You should avoid driving or using heavy machines if you feel drowsy, dizzy, or restless after taking Losulp 25mg Injection, especially during the first few days.
While using Losulp 25mg Injection, you should avoid alcohol, monitor for abnormal movements or hormone changes, take medicine at the same time daily, and do not stop suddenly without medical advice.
Yes. Losulp 25mg Injection may raise prolactin levels, which can cause symptoms like missed periods, milk discharge, or enlarged breasts in both men and women.
Levosulpiride is safe if used at prescribed doses for the prescribed duration as advised by your doctor
No, it is used in the treatment of gastro-oesophageal reflux disease, irritable bowel syndrome, psychosis, dyspepsia
Levosulpiride belong to class of medication called as atypical antipsychotics. It acts by decreasing the activity of dopamine in the brain
Levosulpiride is used in the treatment psychosis, depression, gastro-oesophageal reflux disease, irritable bowel syndrome and dyspepsia
No. patients should follow advice of the doctor regarding the possible side effects.
Losulp 25mg Injection can be safely taken with omeprazole as no harmful effects have been reported clinically. A fixed-dose combination of these two medicines is also available. Losulp 25mg Injection works by increasing the gut motility and Omeprazole decreases the acid production in the stomach. So, this combination is very effective in the treatment of reflux esophagitis associated with acidity, heartburn, intestinal and stomach ulcers.
Fact Box
Chemical Class
Benzamide derivative
Habit Forming
No
Therapeutic Class
NEURO CNS
Action Class
Atypical Antipsychotics
Related lab tests
References
- Lozano R, Concha MP, Montealegre A, et al. Effectiveness and safety of levosulpiride in the treatment of dysmotility-like functional dyspepsia. Ther Clin Risk Manag. 2007;3(1):149-55. [Accessed 23 Jan. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 25 Mar. 2019] (online) Available from:
- Levosulpiride [Patient Information Leaflet]. Bangalore, India: Micro Labs Limited; 2022.
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Disclaimer
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
Marketer details
Name: Mova Pharmaceutical Pvt Ltd
Address: F-11, 2nd Main Road, Anna Nagar East, Chennai - 600 102.
Address: F-11, 2nd Main Road, Anna Nagar East, Chennai - 600 102.
Vendor Details
Country of origin: India
Lab tests offered by us
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- PPBS (Postprandial Blood Sugar)
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid -19 test- RT PCR
- LFT (Liver Function Test)
- KFT (Kidney Function Test)
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid, Serum
- Vitamin B12
- CRP (C-Reactive Protein), Quantitative
- Urine C/S (Urine Culture and Sensitivity)
- Serum Electrolytes
- Serum Calcium
- Serum Creatinine
- Diabetes Screening (HbA1C & Fasting Sugar)
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hb (Hemoglobin)
- Complete Hemogram (CBC & ESR)
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