Lorbriqua 25mg Tablet is used to treat adults with unresectable (unremovable), advanced, or recurrent forms of non-small cell lung cancer (NSCLC). It works by inhibiting an enzyme called anaplastic lymphoma kinase (ALK) and is given to patients who have an alteration in this enzyme.

Furthermore, Lorbriqua 25mg Tablet is prescribed only to those patients who no longer respond to other ALK inhibitors, such as alectinib or ceritinib. Additionally, it is also effective in treating ALK-positive NSCLC that has spread to the brain.

Take this medicine with or without food, but preferably at the same time each day. Depending on the condition and response to the treatment, the doctor may alter the dose or stop the treatment for a short time. Continue taking this medicine for as long as the doctor has prescribed, and do not stop suddenly.

Some common side effects of Lorbriqua 25mg Tablet include edema (swelling in arms, legs, hands, and feet), peripheral neuropathy (numbness and tingling feeling in joints, arms, and legs), and cognitive disorders (confusion, forgetfulness, and lack of concentration or attention). It may also cause breathlessness, fatigue, weight gain, joint pain, mood changes, and diarrhea. Consult the doctor if any of these side effects are worrisome or worsen. They may adjust the medicine dose and suggest ways to manage them.

Let the doctor know if you have any medical conditions, such as kidney or heart disease, depression, seizures, problems with the heartbeat, or breathing problems. Also, let them know if you have high blood pressure, high levels of cholesterol, or diabetes before starting the treatment with this medicine. Pregnant or breastfeeding women should also consult their doctor before taking this medicine. Some other medications may affect the working of this tablet; therefore, tell the doctor about all the other medicines you may be taking before starting the treatment with this medicine.

There is a Patient Support Program/Patient Assistance Program available in India for this medicine, being managed by Tata 1mg. Please contact your prescribing doctor to know more about the same. You may also call on (1800-102-1618) for more details.

Uses of Lorbriqua Tablet

Treatment of Non-small cell lung cancer

Benefits of Lorbriqua Tablet

In Treatment of Non-small cell lung cancer

Lorbriqua 25mg Tablet helps shrink the tumor size and restricts the spread of cancer to other parts of the body. This medicine can effectively treat cancer that has spread to the brain because it can cross the blood-brain barrier. This barrier is a network of blood and tissue that prevents infectious bacteria and other harmful substances from entering the brain. The use of Lorbriqua 25mg Tablet helps prevent disease progression and reduce the chances of recurrence over a long period.

Side effects of Lorbriqua Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Lorbriqua

Increased triglyceride level in blood
Diarrhea
Cough
Joint pain
Hypercholesterolemia (high cholesterol)
Weight gain
Fatigue
Edema (swelling)
High blood pressure
Peripheral neuropathy (tingling and numbness of feet and hand)
Breathlessness
Mood changes

How to use Lorbriqua Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lorbriqua 25mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Lorbriqua Tablet works

Lorbriqua 25mg Tablet is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Lorbriqua 25mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Lorbriqua 25mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CAUTION

Lorbriqua 25mg Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.

Driving

CONSULT YOUR DOCTOR

It is not known whether Lorbriqua 25mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney

CAUTION

Lorbriqua 25mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Lorbriqua 25mg Tablet may be needed. Please consult your doctor.
However, no dose adjustment is recommended for patients with mild or moderate renal impairment.

Liver

SAFE IF PRESCRIBED

Lorbriqua 25mg Tablet is safe to use in patients with liver disease. No dose adjustment of Lorbriqua 25mg Tablet is recommended.
However, recommended dosage regimen has not been established in cases of moderate to severe hepatic impairment.

What if you forget to take Lorbriqua Tablet?

If you miss a dose of Lorbriqua 25mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

No substitutes found for this medicine

Quick tips

Take Lorbriqua 25mg Tablet at the same time every day to maintain steady levels in your body.
Swallow the medicine whole with water and do not crush, chew, or split it.
Avoid grapefruit or grapefruit juice, as it can increase side effects.
Let your doctor know if you notice mood changes, confusion, or memory problems.
Keep a regular check on your cholesterol and liver levels as advised during Lorbriqua 25mg Tablet treatment.
Take Lorbriqua 25mg Tablet at the same time every day to maintain steady levels in your body.
Swallow the medicine whole with water and do not crush, chew, or split it.
Avoid grapefruit or grapefruit juice, as it can increase side effects.
Let your doctor know if you notice mood changes, confusion, or memory problems.
Keep a regular check on your cholesterol and liver levels as advised during Lorbriqua 25mg Tablet treatment.

Fact Box

Chemical Class

Phenylpropanoid derivatives

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Tyrosine Kinase Inhibitors (TKIs)

Interaction with drugs

Taking Lorbriqua with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Phenytoin (Oral Route) Severe

Do not consume Lorlatinib with Phenytoin. Phenytoin may reduce blood levels of Lorlatinib.

Phenytoin (Injection Route) Severe

Do not consume Lorlatinib with Phenytoin. Phenytoin may reduce blood levels of Lorlatinib.

Pimozide (Oral Route) Severe

Do not consume Lorlatinib with Pimozide. Lorlatinib may reduce blood levels of Pimozide.

Primidone (Oral Route) Severe

Do not consume Lorlatinib with Primidone. Primidone may reduce blood levels of Lorlatinib.

Ethinyl Estradiol (Injection Route) Severe

Do not consume Lorlatinib with Ethinyl Estradiol. Lorlatinib may reduce blood levels of Ethinyl Estradiol.

View all drug interactions

Patient concerns

What is the purpose of Chemotherepy given at the time of radiotherapy in ca lung small cell carcinoma

Dr. Vijay Sharnangat

Medical Oncology and Hematology

This is given to enhance the therapeutic effect of radiation therapy which is curative for small cell lung cancer.

Right lung tumour cancer in upper portion In jalgaon district which oncologist is best for lung cancer.

Dr. Vijay Sharnangat

Medical Oncology and Hematology

Dr Nitin Chaudhari us best oncologist

My father in law is a lung cancer patient.He had gone through two chemo cycles.The first one led to a significant reduction of about 50% in the tumor size.He was administered gemcitabine and carboplatin.However,the 2nd one was ineffective.Please advise as to what could be the next course of action. He was a smoker and has non-small cell carcinoma.The cancer has spread to the adrenal glands.

Dr. Sanjay Singh Rai

Medical Oncology and Hematology

U have to do a CT SCAN 3WKS AFTER 3RD CHEMOBased on that u make assessment of response

What is Lorbriqua 25mg Tablet used for?

Lorbriqua 25mg Tablet is a targeted therapy medicine used to treat non-small cell lung cancer (NSCLC) that has spread to other parts of the body (metastatic). It is specifically for patients whose cancer has a specific genetic mutation called ALK-positive (anaplastic lymphoma kinase-positive).

Is Lorbriqua 25mg Tablet effective for lung cancer patients who have failed previous ALK therapies?

Yes, Lorbriqua 25mg Tablet is especially designed for ALK-positive NSCLC patients whose cancer has worsened despite earlier treatments with ALK inhibitors like crizotinib, ceritinib, or alectinib. It is known for its ability to work even after resistance to these anticancer medicines develops.

Can Lorbriqua 25mg Tablet cause serious mental or mood changes?

Yes, Lorbriqua 25mg Tablet affects your brain and mood. Some patients may experience confusion, memory problems, mood swings, hallucinations, or speech difficulties. Always inform your doctor if you notice unusual changes in thinking, sleep, or behavior.

Is it safe to take Lorbriqua 25mg Tablet if I am pregnant or planning to become pregnant?

No, Lorbriqua 25mg Tablet may harm an unborn baby. Women of childbearing potential should use a non-hormonal birth control method during treatment and for at least 35 days after stopping. Men should also use effective contraception for 14 weeks after stopping Lorbriqua 25mg Tablet.

Can Lorbriqua 25mg Tablet cause high cholesterol or triglyceride levels?

Yes, Lorbriqua 25mg Tablet can significantly raise cholesterol and triglyceride levels in your blood. Doctors may prescribe lipid-lowering medicines to manage this. Regular blood tests will be needed to monitor your lipid profile during treatment.

Can Lorbriqua 25mg Tablet cause heart problems?

Yes, Lorbriqua 25mg Tablet can cause heart rhythm issues such as atrioventricular (AV) block or PR interval prolongation. Your doctor may perform ECG tests before and during Lorbriqua 25mg Tablet treatment, especially if you have a history of heart disease.

What are the warning signs of serious lung problems from Lorbriqua 25mg Tablet?

If you develop symptoms like shortness of breath, coughing, or fever, it may indicate lung inflammation (pneumonitis or ILD), which is a rare but serious side effect of Lorbriqua 25mg Tablet. Inform your doctor immediately if you experience any of these symptoms, as treatment may need to be stopped.

How long does it take for Lorbriqua 25mg Tablet to work?

The time it takes to see results varies from person to person. Some patients may notice improvement within a few weeks, while others may take longer. Your doctor will monitor your progress through regular check-ups and scans.

Can I stop taking Lorbriqua 25mg Tablet if I feel better?

No, do not stop taking Lorbriqua 25mg Tablet without consulting your doctor. Stopping the medication abruptly can cause the cancer to grow or spread. Always follow your doctor’s instructions.

Can Lorbriqua 25mg Tablet cure my cancer?

Lorbriqua 25mg Tablet is not a cure for cancer, but it can help control the growth and spread of ALK-positive non-small cell lung cancer. It may improve symptoms and prolong survival in some patients.

Will I need regular tests during Lorbriqua 25mg Tablet treatment?

Yes, your doctor will likely advise regular blood tests, scans, and check-ups to monitor your response to the treatment and check for any side effects.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.