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MRP: Rs. 14.50 for 1 strip(s) (20 tablets each)
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Composition for LOMOTIL

Diphenoxylate(2.5 mg),Atropine(0.025 mg)

food interaction for LOMOTIL

alcohol interaction for LOMOTIL

pregnancy interaction for LOMOTIL

lactation interaction for LOMOTIL

There is no data available. Please consult doctor before consuming the drug.
Lomotil tablet may cause excessive drowsiness and calmness with alcohol.
Lomotil tablet may be unsafe to use during pregnancy.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Diphenoxylate(2.5 mg)


Diphenoxylate is used in combination with atropine (along with appropriate fluid and electrolyte therapy) for treatment of diarrhea, (loose stools).

How it works

Diphenoxylate belongs to a class of medications called antidiarrheal agents. It works by decreasing the movement of bowel.

Common side effects

Vomiting, Nausea, Numbness of extremity, Decreased urination, Abdominal bloating, Abdominal pain, Acne-like rash, Facial swelling, Allergic reaction, Confusion, Difficulty in swalloing, Shortness of breath, Flushing, Dry skin, Fatigue, Headache, Hoarseness of voice, Loss of appetite, Mood changes, Restlessness, Tachycardia, Itching, Urticaria
Atropine(0.025 mg)


Atropine is used in the form of eye drops for treatment of infections and inflammation of eyes, for relaxing the eye muscles before eye examination especially in children (cycloplegic refraction), and to widen the pupil. As a tablet and injection, it is used to reduce production of saliva and other body fluids before general anesthesia, to raise the heart rate if it has become too slow (after heart attack or certain drugs), and for relief of symptoms of organo phosphorus (pesticide) poisoning. Tablets are also used in certain inflammatory gut disorders.

How it works

Atropine belongs to class of medication called as anticholinergic drugs. It acts by blocking the activity chemicals (acetylcholine) in the body, thereby producing effects such as reduction of salivary and other body secretions, relief of abdominal pain due to cramps, increase in the heart rate, and widening of the pupil.

Common side effects

Vomiting, Nausea, Confusion, Dry mouth, Dry skin, Difficulty in urination, Eye irritation, Eyelid swelling, Altered heart rate, Eye redness, Skin redness, Tachycardia, Blurred vision, Photosensitivity, Fever

Common Dosage

Patients taking this medicines

  • 44%
    One Time A Day
  • 38%
    Two Times A Day
  • 19%
    Three Times A Day


No substitutes found

Top General Physicians

  • Dr. Khoobsurat Najma
  • Dr. Prabhat Kumar Jha
    MBBS, MD
  • Dr. Ashutosh Shukla
    MBBS, MD, Diploma, Fellowship
  • Dr. Sushila Kataria
    MBBS, MD, Diploma
  • Dr. R. R. Dutta
    MBBS, MD

Expert advice for LOMOTIL

  • Appropriate fluid and electrolyte therapy should be given to protect against dehydration. If severe dehydration or electrolyte imbalance is present medication should be discontinued.
  • Consult your doctor before taking diphenoxylate, if you have heart, liver or kidney problems; Down syndrome (an inherited condition causing a range of developmental and physical problems);prostate problems (enlarged prostate); blockage of the bladder, trouble urinating, hiatal hernia, asthma, open-angle glaucoma, or risk factors for glaucoma.
  • Avoid exposure to hot weather or become over heated while you are being active; heatstroke may occur.

Frequently asked questions for LOMOTIL


Q. What is diphenoxylate hydrochloride and atropine sulfate?
Diphenoxylate and atropine combination medication is a combination medicine used for treatment of diarrhea.


Q. Is atropine a controlled substance?
No, it is available as prescription drug.
Q. Is atropine a beta blocker /calcium channelblocker/adrenaline/ parasympathomimetic/vasopressor?
No, atropine belongs to class of medication called as anticholinergics or cholinergic antagonist.
Q. Is atropine an agonist or antagonist?
Atropine is an antagonist of cholinergic receptors.
Q. Is atropine a narcotic drug?
No, it is not a narcotic. However, it is often available in combination with drugs that have abuse potential.
Q. Does atropine increase blood pressure/decrease heart rate/sedation/urinary retention/increase contractility?
Atropine decreases heart rate and increases blood pressure; It causes urinary retention as well as decreased contractility of gut and urinary bladder muscles. It does not cause sedation, on the contrary, it causes excitation, sleeplessness and agitation.
Q. Does atropine cross placenta?
Yes, small amount of atropine can cause placenta. Always follow your doctor’s advice regarding its use.
Q. Does atropine block activity of acetylcholine /nicotinic receptor?
Yes, atropine acts by inhibiting the activity of acetylcholine on muscarinic and nicotinic receptors.


Content on this page was last updated on 28 September, 2016, by Dr. Varun Gupta (MD Pharmacology)