Leevarin 15 Tablet

Calcium Leucovorin (15mg)

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Leevarin 15 Tablet is used to prevent the harmful effects of methotrexate (anticancer medicine). It is also used in the treatment of methotrexate overdose.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 14 Apr 2026 | 04:20 PM (IST)

₹441 MRP ₹49912% off

Gurgaon

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General Information

Storage

Store below 25°C

The content is shown in English

Product introduction

Leevarin 15 Tablet can be taken with or without food. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects.

It is generally safe medicine to use with no common side effects if taken in the right amount. Your doctor may request regular blood tests to monitor your blood cells and serum methotrexate concentration in the blood.

Before taking it, tell your doctor if have seizures, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using, especially phenytoin for your seizures.

Uses of Leevarin Tablet

Benefits of Leevarin Tablet

Prevention of Harmful effects of methotrexate
Leevarin 15 Tablet helps protect the body cells against the harmful effects of methotrexate, an anti-cancer medicine. It is a form of vitamin B that is given after 24 hours of methotrexate administration. This makes sure that methotrexate has achieved its anti-cancer effects and also, Leevarin 15 Tablet will prevent the other side effects such as anemia.

How to use Leevarin Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Leevarin 15 Tablet may be taken with or without food.

How Leevarin Tablet works

Leevarin 15 Tablet is a form of folinic acid that helps protect healthy cells from the toxic effects of methotrexate, a chemotherapy drug. Methotrexate works by blocking folic acid, which is needed for cell growth. Leevarin 15 Tablet bypasses this block by supplying a usable form of folate directly to the body. This helps rescue normal cells without reducing methotrexate’s effect on cancer cells.

All substitutes for Leevarin 15 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Leucorin Tablet

by Samarth Life Sciences Pvt Ltd

₹50.77/tablet

15% costlier

Quick tips

You have been prescribed Leevarin 15 Tablet to reduce the side effects of the medicine methotrexate.
Take it 24 hours after taking methotrexate. If taken at the same time, it may counteract the effect of methotrexate.
Inform your doctor if you are also taking certain medications such as phenytoin for your seizures as Leevarin 15 Tablet may counteract the antiepileptic effects.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Leevarin 15 Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Leevarin 15 Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Leevarin 15 Tablet during breastfeeding is not available. Please consult your doctor.

Driving

SAFE

Leevarin 15 Tablet does not usually affect your ability to drive.

Kidney

CAUTION

Leevarin 15 Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Leevarin 15 Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Leevarin with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Capecitabine (Oral Route)

If concurrent use is essential, your doctor may closely monitor treatment outcomes and may modify treatment if required.

Frequently asked questions

What is Leevarin 15 Tablet used for?

Leevarin 15 Tablet is used to prevent harmful effects of methotrexate (a cancer chemotherapy medication) when methotrexate is used to treat certain types of cancer. Leevarin 15 Tablet is also used to treat people who have accidentally received an overdose of methotrexate or similar medications. It is also used for the treatment of megaloblastic anemia due to folic acid deficiency and when oral therapy is not feasible.

What is megaloblastic anemia?

Anemia is a blood disorder in which the number of red blood cells (RBCs) that carry oxygen is lower than usual. As a result, your tissues and organs don’t get enough oxygen. Megaloblastic anemia is a form of anemia characterized by very large red blood cells and a decrease in the number of those cells. Usually, megaloblastic anemia is due to vitamin B12 or folic acid deficiency.

How long does it take for Leevarin 15 Tablet to work?

Leevarin 15 Tablet starts acting on the body within 20-30 minutes of oral intake. However, this might vary with respect to dosage, the patient receiving the drug, and response to treatment.

What are some of the laboratory tests conducted before or during the treatment with Leevarin 15 Tablet?

Your doctor will prescribe blood tests to check your levels of serum methotrexate concentration (in case of methotrexate chemotherapy or overdose) to determine the optimal dose and duration of treatment with Leevarin 15 Tablet. You will also be prescribed a complete blood count to monitor the number of red blood cells (in case of megaloblastic anemia). Along with this, your calcium levels will also be monitored in order to prevent hypercalcemia (excess calcium) since Leevarin 15 Tablet contains calcium.

Fact Box

Chemical Class

Folic acid derivative

Habit Forming

Therapeutic Class

BLOOD RELATED

Action Class

Folic Acid Analogs

References

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Admac Pharma Ltd
Address: SCO 84, Sector 5, Panchkula (Haryana), 134112 INDIA.

Vendor Details

Country of origin: India

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Leevarin 15 Tablet

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General Information

Contains

Salt Synonyms

Marketer

Storage

Product introduction

Uses of Leevarin Tablet

Benefits of Leevarin Tablet

How to use Leevarin Tablet

How Leevarin Tablet works

All substitutes for Leevarin 15 Tablet

Leucorin Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Capecitabine (Oral Route)

Frequently asked questions

What is Leevarin 15 Tablet used for?

What is megaloblastic anemia?

How long does it take for Leevarin 15 Tablet to work?

What are some of the laboratory tests conducted before or during the treatment with Leevarin 15 Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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