Medicine Overview of Larentine Tablet
Larentine 10mg Tablet is used in the treatment of Alzheimer's disease
. It should be used in patients with moderate to severe Alzheimer's disease.
Dizziness, Headache, Confusion, Constipation.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Larentine 10mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Memory loss in Alzheimer’s disease is due to an imbalance of chemical messengers in the brain. Larentine 10mg Tablet works by blocking the action of glutamate, a chemical messenger involved in the transmission of nerve signals.
In Depth Information on Larentine Tablet
Larentine Tablet related warnings
Interaction with alcohol is unknown. Please consult your doctor.
Larentine 10mg Tablet is probably safe to use during pregnancy.
Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.
No information is available on the use of Larentine 10mg Tablet during lactation. Please consult your doctor.
Larentine 10mg Tablet may cause side effects which could affect your ability to drive.
Larentine 10mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Larentine 10mg Tablet may be needed. Please consult your doctor.
Larentine 10mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Larentine 10mg Tablet may be needed. Please consult your doctor.
Limited information is available on the use of Larentine 10mg Tablet in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.
If you miss a dose of Larentine 10mg Tablet, skip it and continue with your normal schedule. Do not double the dose.
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Frequently asked questions about Larentine Tablet
A psychotropic drug is a medicine affecting the mind, emotions, and behaviour. Larentine has a beneficial effect on the behavioural symptoms of patients with moderate to severe Alzheimer's Disease. Therefore it is considered as a psychotropic agent.
No. Larentine is not a narcotic. It does not have habit forming potential.
No. Mood stabilisers are used to treat mania and bipolar disorder. Larentine is not approved for these conditions yet, although studies are going on for the role of Larentine in these diseases also.
No. Larentine does not fit in the generally accepted "Nootropic" descriptor for healthy people. Nootropics are drugs which increase cognition/ motivation/ creativity in healthy individuals. Larentine, on the other hand, improves cognition in patients with Alzheimer's Disease.
Q. Is Larentine a cholinesterase inhibitor?
No. Larentine does not function by inhibiting the cholinesterase enzyme found in the endings of nerve cells. Rather, it acts by preventing the toxicity of an excitatory substance called glutamate in the brain.
Yes. Larentine acts as an antagonist at the NMDA receptor. This is the receptor in the brain through which glutamate, an excitatory substance, damages the nerve cells in the brain, which is found in Alzheimer's disease.
Cmax (Peak plasm concentration) of Larentine is 35-40 ng/ml.
Q. Can I take Larentine with vitamin D?
It has been reported in some studies that a combination of Larentine and Vitamin D improves cognition in Alzheimer's Disease. However, more studies are required to confirm this finding.
Q. Can I take Larentine with vitamin E?
Some studies have reported that among patients with mild to moderate Alzheimer's disease, taking alpha-tocopherol (Vitamin E) with Larentine slows the progressive functional decline. However, more studies are required to confirm this finding.
Larentine is started when a person starts suffering from moderate to severe Alzheimer's Disease and has failed other options. Despite years of research for mild Alzheimer's Disease, Larentine has not been found to be useful in it.
Larentine is prescribed to improve the cognitive (memory) function in patients with Alzheimer's Disease when other treatment options like cholinesterase enzyme inhibitors have failed.
Q. What is the interaction of Larentine with metformin?
The interaction between Larentine and Metformin is minor. Larentine oral increases the level or effect of metformin by nonacidic drugs competing for the same pathway through the kidney.
Q. What is the interaction of Larentine with warfarin?
No known interaction between Larentine and Warfarin has been found.
The role of Larentine in Lewy Body Dementia (LBD) is controversial. Some studies suggest that it is safe and efficacious in this disease whereas others have shown exacerbation of LBD due to Larentine. Larentine is not approved for use in Lewy Body Dementia.
Q. Can Larentine combined with donepezil?
A combination of Larentine and Donepezil can be given in moderate to severe Alzheimer's Disease. It has been shown that the combination may have additive effects i.e. effects of both drugs are added when given together in some studies.
Q. Can Larentine be used with rivastigmine?
Larentine in combination with rivastigmine is safe and beneficial in patients with Alzheimer's Disease. Patients have improvement or stabilisation on dual therapy.
Larentine is not indicated for use in chronic pain. It has been proposed as a medication for the treatment of neuropathic pain for its mechanism, safety, lack of serious adverse effects, and the relatively rapid onset of action. However, studies have not been promising so far and its routine use in neuropathic pain is not currently recommended.
Larentine is not indicated for use in Opioid withdrawal. In a number of small studies, it has been seen that Larentine decreased the expression of opioid physical dependence in humans but there is a need for more studies in this field.
Larentine has failed to demonstrate clinical efficacy in autism. Studies are currently in progress for other clinical applications.
Larentine has failed to demonstrate clinical efficacy in vascular dementia although it was well-tolerated.
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