JakOne 15 Tablet ER

Upadacitinib (15mg)

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JakOne 15 Tablet ER is a medication used to treat ulcerative colitis, a condition that causes inflammation in the colon. It works by blocking specific immune signals that trigger inflammation, thereby helping to reduce pain, bleeding, and bowel discomfort, while promoting healing.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 22 May 2026 | 06:22 PM (IST)

₹677 MRP ₹74910% off

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JakOne 15 Tablet ER

strip of 10 tablet er

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Same composition

Upadacip 15mg Tablet ER

strip of 10 tablet er

Upadacitinib (15mg)

by Cipla Ltd

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General Information

Contains

Upadacitinib (15mg)

Marketer

Dr. Reddys Laboratories Limited

Storage

Store below 30°C

The content is shown in English

Product introduction

To get the most benefit from JakOne 15 Tablet ER, it is important to take it exactly as prescribed by your doctor. Skipping doses or stopping the medication suddenly may reduce its effect and worsen symptoms. Regular follow-ups with your doctor help monitor your progress and adjust treatment if needed.

Common side effects of JakOne 15 Tablet ER include upper respiratory tract infections, acne, increased liver enzymes, fever, and rash. If any of these side effects persist or worsen, discuss them with your doctor. They may be able to provide supportive treatments or adjust your dosage.

JakOne 15 Tablet ER should not be used if you have a serious infection or are allergic to it. Inform your doctor if you have liver problems, kidney issues, or a history of tuberculosis or other infections. Avoid live vaccines while on this medication, and always discuss any other medications you are taking.

Uses of JakOne Tablet ER

Treatment of Ulcerative colitis

Benefits of JakOne Tablet ER

Treatment of Ulcerative colitis
Ulcerative colitis is a condition that causes inflammation and sores in the colon, leading to pain, bleeding, and frequent stools. JakOne 15 Tablet ER helps reduce inflammation, relieves these symptoms, promotes healing of the colon lining, and improves overall digestive comfort.

Side effects of JakOne Tablet ER

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of JakOne

Decreased white blood cell count (neutrophils)
Upper respiratory tract infection
Increased creatine phosphokinase (CPK) level in blood
Acne
Increased liver enzymes
Fever
Rash

How to use JakOne Tablet ER

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. JakOne 15 Tablet ER may be taken with or without food.

How JakOne Tablet ER works

JakOne 15 Tablet ER works by selectively inhibiting Janus kinase 1 (JAK1), an enzyme involved in the body’s immune response. It blocks JAK1 activity and reduces the overactive immune signaling that causes inflammation in the colon. This helps decrease swelling and tissue damage. It allows the intestinal lining to heal and improves symptoms such as abdominal pain, bleeding, and frequent bowel movements.

All substitutes for JakOne 15 Tablet ER

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Before starting JakOne 15 Tablet ER, the doctor will screen for infections, including tuberculosis, hepatitis B/C, and assess liver and renal function before initiating therapy.
The doctor will monitor for signs of infection during treatment. Withhold therapy if a serious infection develops.
Doctor administer necessary vaccinations before starting JakOne 15 Tablet ER therapy. Avoid live vaccines during treatment.
Tell your doctor about all medications you are taking to avoid potential drug-drug interactions.
Inform your doctor if you currently smoke or have smoked in the past, as this medicine may increase the risk of certain cancers such as lymphoma or lung cancer.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with JakOne 15 Tablet ER. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

JakOne 15 Tablet ER is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

JakOne 15 Tablet ER may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

CONSULT YOUR DOCTOR

It is not known whether JakOne 15 Tablet ER alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of JakOne 15 Tablet ER in patients with kidney disease. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of JakOne 15 Tablet ER in patients with liver disease.

Frequently asked questions

What is JakOne 15 Tablet ER used for?

It is used to treat moderate to severe ulcerative colitis when other treatments have not worked well.

How does JakOne 15 Tablet ER help?

It reduces inflammation in the gut, which helps control symptoms like diarrhea, bleeding, and stomach pain.

How should I take JakOne 15 Tablet ER?

Take it exactly as prescribed by your doctor, usually once daily. Do not skip the doses.

Can I stop JakOne 15 Tablet ER if I feel better?

No, stopping suddenly may cause symptoms to worsen. Always consult your doctor before changing the dose.

Can I get vaccinated while taking JakOne 15 Tablet ER?

Avoid live vaccines. Inform your doctor before getting any vaccine.

Fact Box

Chemical Class

Janus Kinase (JAK) inhibitors

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

Janus kinase inhibitors

Related lab tests

Anti Neutrophilic Cytoplasmic Antibody - P

C- Reactive Protein Quantitative

Erythrocyte Sedimentation Rate

References

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Dr. Reddys Laboratories Limited
Address: Global Distribution Centre, Survey No. 41, Bachupally (V), Bachupally (M), Medchal - Malkajgiri (Dist.), Hyderabad - 500 090, Telangana, INDIA

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Home

Gastro Intestinal

Intestinal Anti Inflammatory Agents

JakOne 15 Tablet ER

JakOne 15 Tablet ER

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of JakOne Tablet ER

Benefits of JakOne Tablet ER

Side effects of JakOne Tablet ER

How to use JakOne Tablet ER

How JakOne Tablet ER works

All substitutes for JakOne 15 Tablet ER

Upadoz 15 Eco Pack Tablet ER

Jakit 15 Tablet ER

Upadacip 15mg Tablet ER

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is JakOne 15 Tablet ER used for?

How does JakOne 15 Tablet ER help?

How should I take JakOne 15 Tablet ER?

Can I stop JakOne 15 Tablet ER if I feel better?

Can I get vaccinated while taking JakOne 15 Tablet ER?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Anti Neutrophilic Cytoplasmic Antibody - P

C- Reactive Protein Quantitative

Erythrocyte Sedimentation Rate

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests