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Upadacitinib

INFORMATION ABOUT UPADACITINIB

Upadacitinib Uses

Upadacitinib is used in the treatment of Ulcerative colitis.

How Upadacitinib works

Upadacitinib works by selectively inhibiting Janus kinase 1 (JAK1), an enzyme involved in the body’s immune response. It blocks JAK1 activity and reduces the overactive immune signaling that causes inflammation in the colon. This helps decrease swelling and tissue damage. It allows the intestinal lining to heal and improves symptoms such as abdominal pain, bleeding, and frequent bowel movements.

Common side effects of Upadacitinib

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common
Upper respiratory tract infection, Increased creatine phosphokinase (CPK) level in blood, Acne, Decreased white blood cell count (neutrophils), Increased liver enzymes, Fever, Rash
CONTENT DETAILS
Last updated
30 Dec 2025 | 09:24 AM (UTC)
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Medicine brands for Upadacitinib

Upadoz
₹1725 to ₹5990
MSN Laboratories Private Limited
3 variant(s)

Expert advice for Upadacitinib

  • Before starting Upadacitinib, the doctor will screen for infections, including tuberculosis, hepatitis B/C, and assess liver and renal function before initiating therapy.
  • The doctor will monitor for signs of infection during treatment. Withhold therapy if a serious infection develops.
  • Doctor administer necessary vaccinations before starting Upadacitinib therapy. Avoid live vaccines during treatment.
  • Tell your doctor about all medications you are taking to avoid potential drug-drug interactions.
  • Inform your doctor if you currently smoke or have smoked in the past, as this medicine may increase the risk of certain cancers such as lymphoma or lung cancer.

Frequently asked questions for Upadacitinib

It is used to treat moderate to severe ulcerative colitis when other treatments have not worked well.
It reduces inflammation in the gut, which helps control symptoms like diarrhea, bleeding, and stomach pain.
Take it exactly as prescribed by your doctor, usually once daily. Do not skip the doses.
No, stopping suddenly may cause symptoms to worsen. Always consult your doctor before changing the dose.
Avoid live vaccines. Inform your doctor before getting any vaccine.