JakAVI 20mg Tablet
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Product introduction
JakAVI 20mg Tablet is a medicine used to treat certain blood disorders, mainly chronic idiopathic myelofibrosis and polycythemia vera. These conditions affect how bone marrow makes blood cells. It works by blocking specific enzymes that play a key role in the signals that control blood cell production.
JakAVI 20mg Tablet can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Headache, dizziness, low platelet count are some common side effects of this medicine. This medicine may reduce the number of blood cells (decrease red blood) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, kidney and lipid levels.
Before taking it, tell your doctor if you have liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of JakAVI Tablet
- Treatment of Chronic idiopathic myelofibrosis
- Treatment of Polycythemia vera
Benefits of JakAVI Tablet
In Treatment of Chronic idiopathic myelofibrosis
Chronic idiopathic myelofibrosis is a rare bone marrow disorder where scar tissue forms inside the marrow, leading to symptoms like fatigue, anemia, and an enlarged spleen. JakAVI 20mg Tablet helps reduce spleen size and ease symptoms such as night sweats and bone pain, improving overall quality of life.
In Treatment of Polycythemia vera
Polycythemia vera is a blood disorder where the body produces too many red blood cells, thickening the blood and increasing the risk of clots. JakAVI 20mg Tablet helps lower blood cell counts and control symptoms like itching and headaches, reducing the risk of serious complications.
Side effects of JakAVI Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of JakAVI
- Anemia (low number of red blood cells)
- Low blood platelets
- Dizziness
- Infection
- Fatigue
- Decreased white blood cell count (neutrophils)
- Headache
- Increased alanine aminotransferase
- Bruising
How to use JakAVI Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. JakAVI 20mg Tablet may be taken with or without food.
How JakAVI Tablet works
JakAVI 20mg Tablet is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with JakAVI 20mg Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
JakAVI 20mg Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding
UNSAFE
JakAVI 20mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
CONSULT YOUR DOCTOR
It is not known whether JakAVI 20mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney
CAUTION
JakAVI 20mg Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Use of JakAVI 20mg Tablet is not advised in patients with moderate to severe kidney disease.
Use of JakAVI 20mg Tablet is not advised in patients with moderate to severe kidney disease.
Liver
CAUTION
JakAVI 20mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment may be needed.
What if you forget to take JakAVI Tablet?
If you miss a dose of JakAVI 20mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
JakAVI 20mg Tablet
₹4072.43/Tablet
JakAVI 20mg Tablet PAP
Novartis India Ltd
₹0.1/tablet
100% cheaper
Quick tips
- JakAVI 20mg Tablet can be taken with or without food, but take it at the same time each day.
- It may cause dizziness and headaches. Do not drive or do anything that requires mental focus until you know how it affects you.
- Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
- Your doctor may get regular blood tests done to monitor your blood cells, liver and kidney function, and lipid levels during treatment with this medicine.
- Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
- Do not stop taking JakAVI 20mg Tablet without talking to your doctor first.
Fact Box
Chemical Class
Pyrrolo [2,3- d] pyrimidines
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Tyrosine Kinase Inhibitors (TKIs)
Interaction with drugs
Taking JakAVI with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
If concurrent use is essential, watch out for bleeding and consult your doctor immediately.
Concurrent use may increase the risk of bleeding.
If concurrent use is essential, watch out for bleeding and consult your doctor immediately.
Concurrent use may increase the risk of bleeding.
If concurrent use is essential, watch out for bleeding and consult your doctor immediately.
Concurrent use may increase the risk of bleeding.
If concurrent use is essential, watch out for bleeding and consult your doctor immediately.
Concurrent use may increase the risk of bleeding.
If concurrent use is essential, watch out for bleeding and consult your doctor immediately.
Concurrent use may increase the risk of bleeding.
Patient concerns
User feedback
Patients taking JakAVI 20mg Tablet
Twice A Day
80%
Once A Day
20%
What are you using JakAVI Tablet for?
Chronic idiop*
75%
Others
25%
*Chronic idiopathic myelofibrosis
How much was the improvement?
Poor
50%
Excellent
33%
Average
17%
What were the side-effects while using JakAVI 20mg Tablet?
Headache
25%
Low blood pla*
25%
Anemia (low n*
25%
Dizziness
25%
*Low blood platelets, Anemia (low number of red blood cells)
How do you take JakAVI Tablet?
With food
100%
Please rate JakAVI 20mg Tablet on price
Expensive
100%
FAQs
What is JakAVI 20mg Tablet used for?
JakAVI 20mg Tablet is prescribed to treat certain blood disorders such as myelofibrosis and polycythemia vera. It may also be used in graft-versus-host disease (in individuals aged 12 years and older). It works by reducing abnormal blood cell activity and easing symptoms such as an enlarged spleen, night sweats, and itching.
Who should not take JakAVI 20mg Tablet?
There are no absolute contraindications listed, but JakAVI 20mg Tablet should not be used in individuals with uncontrolled infections or very low blood counts unless a doctor determines that the benefits outweigh the risks. Always consult your doctor before starting this medicine.
Can JakAVI 20mg Tablet increase the risk of infections?
Yes. JakAVI 20mg Tablet can weaken your immune system and increase the risk of serious infections, including tuberculosis, shingles, and bacterial or viral illnesses. Report any fever, cough, painful skin rash, or unusual symptoms to your doctor immediately.
Can stopping JakAVI 20mg Tablet suddenly be dangerous?
Yes. Stopping JakAVI 20mg Tablet suddenly may cause your symptoms—such as spleen pain or blood abnormalities—to return quickly or worsen. Do not discontinue this medicine on your own. Your doctor may reduce the dose gradually if needed.
Can JakAVI 20mg Tablet cause low blood counts?
JakAVI 20mg Tablet may cause anemia (low red blood cells), thrombocytopenia (low platelets), or neutropenia (low white blood cells). These conditions can increase the risk of bleeding, fatigue, or infections. Your doctor will monitor your blood counts regularly during treatment.
Does JakAVI 20mg Tablet increase the risk of skin cancer?
Yes. JakAVI 20mg Tablet may increase the risk of non-melanoma skin cancers such as basal cell carcinoma or squamous cell carcinoma. Regular skin examinations and sun protection are recommended while using this medicine.
Can JakAVI 20mg Tablet affect cholesterol levels?
JakAVI 20mg Tablet may raise cholesterol levels. Your doctor will monitor your lipid profile during treatment and may prescribe medication if needed to manage it.
Can JakAVI 20mg Tablet cause blood clots?
Yes. Some individuals taking JakAVI 20mg Tablet may develop blood clots in the veins or arteries. If you experience sudden leg pain, swelling, chest pain, or difficulty breathing, seek medical attention immediately.
Does JakAVI 20mg Tablet increase the chance of other cancers?
Yes, JakAVI 20mg Tablet may increase the risk of developing secondary cancers, especially in people who currently smoke or have smoked in the past. Your doctor will monitor you for signs of new malignancies during long-term treatment.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1240.
- Ruxolitinib. Greenville, North Carolina: DSM Pharmaceuticals, Inc.; 2011. [Accessed 24 Jan. 2019] (online) Available from:
- Ruxolitinib. Wilmington, Delaware: Incyte Corporation; 2011 [revised Dec. 2014]. [Accessed 27 Mar. 2019] (online) Available from:
- Ruxolitinib. Camberley, Surrey: Novartis Pharmaceuticals UK Ltd; 2012 [revised 22 May 2018]. [Accessed 27Mar. 2019] (online) Available from:
Marketer details
Name: Novartis India Ltd
Address: Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Country of origin: India
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14.0 tablets in 1 strip
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JakAVI 20mg Tablet
strip of 10 tablets
by Novartis India Ltd
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₹49266
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