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Istamet G 50mg/1mg/1000mg Tablet IR

Product introduction

Istamet G 50mg/1mg/1000mg Tablet IR is a combination of three medicines used to lower blood glucose levels in people with type 2 diabetes mellitus. It is generally prescribed when diet, exercise, and other treatments do not result in adequate glycemic control.

Istamet G 50mg/1mg/1000mg Tablet IR is best taken with food; however, take this medicine regularly and at the same time each day to get maximum benefits. The dose and duration are decided according to your condition and how well you respond to it. The doctor may also monitor your blood sugar levels regularly when you are taking this combination medicine.


Keep taking this medicine even if you feel well or your blood sugar levels are controlled. If stopped abruptly, your blood sugar levels could rise and put you at risk of complications. This medication is only part of a treatment program that should also include a healthy diet, regular exercise, and weight reduction because lifestyle habits play a big part in controlling diabetes.


The most common side effects of Istamet G 50mg/1mg/1000mg Tablet IR include hypoglycemia and headache. You may also experience other side effects like nausea, diarrhea, abdominal pain, constipation, and vomiting. Let your doctor know if any of these side effects do not go away or get worse. They may be able to help by adjusting the dosage or by prescribing an alternate medicine.


You should not take Istamet G 50mg/1mg/1000mg Tablet IR if you have type 1 diabetes mellitus or acute or chronic metabolic acidosis, including diabetic ketoacidosis. Patients with active bladder cancer or a history of bladder cancer should also not take this medicine. Inform your doctor about all the other medicines that you take as some of them can affect or be affected by this medication. Pregnant or breastfeeding women should also consult their doctors before taking it.

Uses of Istamet G Tablet IR

Benefits of Istamet G Tablet IR

In Treatment of Type 2 diabetes mellitus

Lowering blood glucose levels is an essential part of managing diabetes as this helps to reduce the risk of serious diabetes-associated complications, such as kidney damage, eye damage, nerve problems, and loss of limbs. Istamet G 50mg/1mg/1000mg Tablet IR helps control high blood glucose (sugar) levels. It also reduces the risk of heart diseases like heart attack or stroke. Taking this medicine regularly along with proper diet and exercise will help you live a normal, healthy life.

Side effects of Istamet G Tablet IR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Istamet G

  • Hypoglycemia (low blood glucose level)
  • Headache
  • Nausea
  • Diarrhea
  • Abdominal pain
  • Constipation
  • Vomiting

How to use Istamet G Tablet IR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Istamet G 50mg/1mg/1000mg Tablet IR is to be taken with food.

How Istamet G Tablet IR works

Istamet G 50mg/1mg/1000mg Tablet IR is a combination of three antidiabetic medications. Sitagliptin helps to control blood sugar levels by increasing substances (incretins) in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood. Glimepiride lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. Metformin decreases the amount of glucose you absorb from your food and the glucose made by the liver. It also increases the body's response to insulin, a natural substance that controls the amount of glucose in the blood (blood sugar levels).

Safety advice

It is unsafe to consume alcohol with Istamet G 50mg/1mg/1000mg Tablet IR.
Istamet G 50mg/1mg/1000mg Tablet IR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
Istamet G 50mg/1mg/1000mg Tablet IR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
Istamet G 50mg/1mg/1000mg Tablet IR should be used with caution in patients with severe kidney disease. Dose adjustment of Istamet G 50mg/1mg/1000mg Tablet IR may be needed. Please consult your doctor.
Istamet G 50mg/1mg/1000mg Tablet IR should be used with caution in patients with severe liver disease. Dose adjustment of Istamet G 50mg/1mg/1000mg Tablet IR may be needed. Please consult your doctor.

What if you forget to take Istamet G Tablet IR?

If you miss a dose of Istamet G 50mg/1mg/1000mg Tablet IR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Istamet G 50mg/1mg/1000mg Tablet IR
₹12.6/Tablet IR
Sitaxa GM 50mg/1mg/1000mg Tablet IR
Torrent Pharmaceuticals Ltd
₹13.6/tablet ir
8% costlier
Azulix SM 50mg/1mg/1000mg Tablet IR
Torrent Pharmaceuticals Ltd
₹13.6/tablet ir
8% costlier
Zoryl MS 50mg/1mg/1000mg Tablet IR
Intas Pharmaceuticals Ltd
₹12.6/tablet ir
same price

Quick tips

  • Prefer taking Istamet G 50mg/1mg/1000mg Tablet IR after a meal or with a snack, as this will reduce the chance of an upset stomach.
  • Istamet G 50mg/1mg/1000mg Tablet IR may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. Always carry some sugary food or fruit juice with you in case you experience hypoglycemia (low blood sugar) symptoms, such as fatigue, dizziness, cold sweats, tremor, and anxiety.
  • If you get unusually thirsty, pass urine more frequently, and feel tired, let your doctor know. These are signs that there is too much sugar in your blood and your dose may need adjusting.
  • Monitor your blood sugar regularly while taking this medicine.
  • Lifestyle changes like low sugar diet, exercising, losing weight, not smoking, and cutting down on alcohol intake may help this medication work better.

Fact Box

Habit Forming
Therapeutic Class

Patient concerns

Diabetes mellitus type 2 ,thirst
Dr. Sanjay Bhatt
A person can control his or her sugar levels by doing regular exercise and walk or regular aerobic exercises at least 30 to 45 minutes per day.MEDICAL NUTRITIONAL THERAPY THAT IS TO MAINTAIN CALORIES INTAKE AS PER BMI .TAKE HELP OF DIABETIC EDUCATOR. VISIT YOUR DOCTOR AND FOLLOW ALL WHAT DOCTOR SUGGESTED.IN TIME ALL ROUTINE INVESTIGATIONS SHOULD BE should not treat it as disease but a start of a healthy life.Uncontrolled sugar levels for long time leads to lower limb weakness which is neuropathy and which is followed by foot ulcers and other complications like kidney or heart problems .online prescription is not allowed without seeing contact doctor nearby for any change or dose adjustment or visit my clinic at gurgaon sector 52 RdCity snergy multi speciality clinic near SRS MARKET
Best medicin for diabetes to me Tell me best medicin for type 2 I am taking Istamet This time my fasting is 238
Dr. Ashwin Porwal
Internal Medicine
ask your treating physician to add another OHA

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.


  1. Sitagliptin/metformin HC [Prescribing Information]. Whitehouse Station: Merck & Co., Inc.; 2012. [Accessed 02 Nov. 2023] (online) Available from: External Link

Marketer details

Name: Sun Pharma Laboratories Ltd
Address: Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Country of origin: India

We do not facilitate sale of this product at present


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